Conference on Fibronectin, Integrins & Related Molecules

纤连蛋白、整合素会议

• 批准号: 6556806
• 负责人: MARTIN J HUMPHRIES
• 金额: $ 2万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-01-17 至 2007-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6556806
• 关键词: fibronectins; integrins; meeting /conference /symposium; protein binding; protein protein interaction; protein structure function; receptor; travel

DESCRIPTION (provided by applicant): Research on cell interactions with extracellular matrices has exploded during the past decade. Fibronectin has been the prototype extracellular matrix molecule for much of this investigation and has been a major focus on this Gordon Conference since 1982. The discovery of integrins in the mid-1980s as receptors for fibronectin and other constituents of extracellular matrices expanded the scope of the conference. The emerging understanding over the last five years that plasma membrane and cytosolic molecular partners regulate integrin function and specificity has further expanded the scope of the conference. Together, fibronectin, integrins, and their binding partners control many basic biological processes including cell adhesion, cell shape, organization of the cytoskeleton and the extracellular matrix, cell motility, regulation of morphogenesis and tissue interactions, immune cell trafficking, regulation of cell activation state and response to growth factors, induction and resolution of inflammation, hemostasis, and wound repair. Important new insights have been made in recent years, including: Determination of the first crystal structure of the extracellular domain of an integrin. This work provides a platform for detail molecular dissection of integrin function. Molecular mechanisms involved in regulation of the activation state of integrins, critical to their ability to bind ligand and transduce signals. The nature and regulation of signaling complexes assembled at adhesion sites, including cytoskeletal components, receptor and non-receptor tyrosine kinases, and other elements of signaling cascades. New families of ligands including growth factors, neuronal and immune adhesion molecules, and disintegrins, and new families of physically-associated molecules including growth factor and other receptors, tetraspanins, caveolin, and multiple cytosolic partners, that have broadened the context within which integrins function. A central role for integrin function and dysfunction in a variety of physiologic and pathologic states, which make these molecules focused therapeutic targets. The conference outlined in this application is directed at communicating these exciting new developments and stimulating discussion among participants from different disciplines. This cross-pollination is a most effective way of stimulating new waves of insight and information.

描述（由申请人提供）：关于细胞与细胞外基质相互作用的研究在过去十年中呈爆炸式增长。 纤连蛋白一直是大部分研究中细胞外基质分子的原型，并且自 1982 年以来一直是戈登会议的主要焦点。20 世纪 80 年代中期，整合素作为纤连蛋白和细胞外基质其他成分的受体的发现扩大了研究范围。会议。 过去五年，人们逐渐认识到质膜和胞浆分子伴侣调节整合素功能和特异性，进一步扩大了会议的范围。 纤连蛋白、整合素及其结合伴侣共同控制许多基本生物过程，包括细胞粘附、细胞形状、细胞骨架和细胞外基质的组织、细胞运动、形态发生和组织相互作用的调节、免疫细胞运输、细胞激活状态的调节以及对生长因子的反应、炎症的诱导和消退、止血和伤口修复。 近年来出现了重要的新见解，包括： 整合素胞外域第一晶体结构的测定。 这项工作为整合素功能的详细分子解剖提供了一个平台。 参与整合素激活状态调节的分子机制，对其结合配体和转导信号的能力至关重要。 在粘附位点组装的信号复合物的性质和调节，包括细胞骨架成分、受体和非受体酪氨酸激酶以及信号级联的其他元件。 新的配体家族，包括生长因子、神经元和免疫粘附分子以及解整合素，以及新的物理相关分子家族，包括生长因子和其他受体、四跨膜蛋白、小窝蛋白和多个胞质伴侣，拓宽了整合素功能的范围。 整合素在各种生理和病理状态下的功能和功能障碍中发挥着核心作用，这使得这些分子成为重点治疗靶点。 本申请中概述的会议旨在交流这些令人兴奋的新发展并激发来自不同学科的参与者之间的讨论。 这种异花授粉是激发新的洞察力和信息浪潮的最有效方式。