CONFERENCE ON FIBRONECTIN/INTEGRINS RELATED MOLECULES

纤连蛋白/整合素相关分子会议

• 批准号: 6223982
• 负责人: Eric J. Brown
• 金额: $ 0.8万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-04 至 2002-02-03
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6223982
• 关键词: cell adhesion molecules; extracellular matrix proteins; fibronectins; integrins; meeting /conference /symposium; travel

DESCRIPTION: (Adapted from Applicant s Abstract) Research on cell interactions with extracellular matrix has exploded during the past decade. Fibronectin has been the prototype extracellular matrix molecule for much of this investigation and has been a major focus of this Gordon Conference since 1982. The discovery of integrins in the mid-1980s as receptors for fibronectin and other constituents of the extracellular matrix expanded the scope of the conference. The emerging understanding over the last five years that integrin function and specificity is regulated by plasma membrane and cytosolic molecular partners has further expanded the scope of the conference. Together, fibronectin, integrins, and their binding partners control many basic biological processes including cell adhesion, cell shape, organization of the cytoskeleton and the extracellular matrix, cell motility, regulation of morphogenesis and tissue interactions, immune cell trafficking, regulation of cell activation state and response to growth factors, induction and resolution of inflammation, hemostasis, and wound repair. The following important new insights have developed in the last four years. First, there is a better understanding of the molecular mechanisms involved in regulation of the activation state of integrins, critical to their ability to bind ligand and transduce signals. Second, there is better insight into the nature and regulation of signaling complexes assembled at adhesion sites, including cytoskeletal components, receptor and non-receptor tyrosine kinases, and other elements of signaling cascades. Third, new families of ligands, including TGF- beta, neuronal and immune adhesion molecules, and disintegrins, as well as new families of physically associated molecules including tetraspanins, caveolin, and multiple cytosolic partners have broadened the context within which integrins function. Fourth, by identifying a central role for integrin function and dysfunction in a variety of physiologic and pathologic states, these molecules are now more appropriate for therapeutic use. The conference outlined in this application is directed at communicating these exciting new developments and stimulating discussion among participants from different disciplines. This cross-pollination is a most effective way of stimulating new waves of insight and information.

描述：（改编自申请人的摘要）研究细胞相互作用 在过去的十年中，随着细胞外基质的爆炸。纤连蛋白具有 作为大部分的原型细胞外基质分子 调查，自1982年以来一直是这次戈登会议的重点。 在1980年代中期发现整联蛋白作为纤连蛋白的受体和 细胞外基质的其他成分扩大了范围 会议。 整合素化的过去五年中的新兴理解 功能和特异性由质膜和胞质调节 分子伙伴进一步扩大了会议的范围。一起， 纤连蛋白，整联蛋白及其约束伴侣控制着许多基本 生物学过程，包括细胞粘附，细胞形状，组织 细胞骨架和细胞外基质，细胞运动，调节 形态发生和组织相互作用，免疫细胞运输，调节 细胞激活状态和对生长因子，诱导和分辨率的反应 炎症，止血和伤口修复。以下重要的新 在过去的四年中，见解发展了。首先，有更好的 了解与调节有关的分子机制 整合素的激活状态，对它们结合配体的能力至关重要 传输信号。 其次，可以更好地了解性质和 调节在粘附部位组装的信号复合物的调节，包括 细胞骨架成分，受体和非受体酪氨酸激酶以及其他 信号级联的要素。第三，新的配体家庭，包括TGF- β，神经元和免疫粘附分子和崩解蛋白以及新的 身体相关的分子家族，包括四叠腺苷，小窝蛋白， 并且多个胞质伴侣扩大了 整联蛋白功能。 第四，通过确定整合素的核心作用 各种生理和病理状态的功能和功能障碍， 这些分子现在更适合治疗。 本申请中概述的会议旨在传达这些 令人兴奋的新发展和刺激参与者之间的讨论 不同的学科。这种交叉授粉是最有效的方法 刺激新的洞察力和信息。