Sub-millimeter precision wireless neuromodulation using a microwave split ring resonator

使用微波开口环谐振器的亚毫米精度无线神经调节

基本信息

批准号：
10516429
负责人：
Ji-Xin Cheng
金额：
$ 24.75万
依托单位：
BOSTON UNIVERSITY (CHARLES RIVER CAMPUS)
依托单位国家：
美国
项目类别：
财政年份：
2022
资助国家：
美国
起止时间：
2022-08-01 至 2025-07-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10516429
关键词：
Action Potentials Address Axon Back Biophotonics Brain Brain Injuries Caliber Cellular Phone Chemicals Chronic Clinical Treatment Communication Contrast Media Copper Couples Development Device or Instrument Development Devices Doctor of Philosophy Electromagnetic Energy Epilepsy Exposure to Frequencies Generations Human Image Implant In Vitro Label Magnetism Mediating Methods Modeling Monitor Mus Neural Inhibition Neuraxis Neurons Ocular dominance columns Optics Pacemakers Pain management Penetration Peripheral Nervous System Peripheral Nervous System Diseases Photons Reporting Research Research Personnel Resolution Risk Scientist Seizures Spottings Technology Time Tissues Titanium Toxic effect Transcranial magnetic stimulation Visual Cortex Work Yang base biomaterial compatibility brain tissue cranium design electric field in vivo Model microwave electromagnetic radiation minimally invasive mouse model multidisciplinary neural stimulation neuroregulation novel relating to nervous system ultrasound wireless wireless electronic wireless fidelity

项目摘要

Project Summary Minimally invasive neural modulation at sub-millimeter spatial resolution remains a critical yet unmet biomedical need. Researchers have explored a broad spectrum of electromagnetic wave and developed wireless neuromodulation methods. Due to its long wavelength, transcranial magnetic stimulation does not provide sufficient spatial resolution to target a functional unit such as a single ocular dominance column in the visual cortex or a diseased peripheral nerve. On the other hand, photons, with their short wavelength, offer micrometer-scale spatial precision but can barely penetrate couple hundred micrometers into the tissue, not to mention the human skull. Microwave (MW), with frequencies between 300 MHz and 300 GHz, fills the gap between optical wave and magnetic wave, yet, has rarely been explored for neuromodulation. We propose a minimally invasive neuromodulation device by taking advantage of a microwave split ring resonator (SRR) design. The SRR has a perimeter of approximately one half of MW wavelength, thus acting as a resonant antenna. It couples the microwave wirelessly and concentrates the microwave at the gap, producing a localized electrical field of ~100 μm in space. Our scientific premise is based on the nonthermal neural inhibitory effect of microwave and the resonance effect of the SRR. The SRR produces concentrated microwave and allows for neuromodulation beyond the microwave diffraction limit, reaching ~100 μm spatial precision. In the proposed work, we will design and fabricate an implantable SRR with titanium for its superior biocompatibility. We will then validate the SRR’s potential in neural inhibition using primary neurons in vitro and a mouse epilepsy model in vivo. By accomplishing the proposed studies, we will have developed a biocompatible and implantable neuromodulation device. The centimeter-scale penetration depth provided by microwave and the sub-millimeter spatial precision provided by SRR promises broad biomedical applications. For central nervous system, our technology allows minimally invasive transcranial modulation of neural activities inside brain and for clinical treatment of epilepsy. A multi-disciplinary team with complementary expertise is assembled to implement the proposed activities.

项目概要亚毫米空间分辨率的微创神经调制仍然是一个关键但尚未得到满足的问题研究人员探索并开发了广泛的电磁波谱。无线神经调节方法由于其波长较长，因此不能进行经颅磁刺激。提供足够的空间分辨率来瞄准功能单元，例如眼睛中的单眼优势柱另一方面，波长短的光子可以提供视觉皮层或患病的周围神经。微米级的空间精度，但几乎不能穿透几百微米到组织中，不频率在 300 MHz 至 300 GHz 之间的微波 (MW) 填补了这一空白。然而，我们提出了一种介于光波和磁波之间的神经调节方法。利用微波裂环谐振器 (SRR) 的微创神经调节装置 SRR 的周长约为 MW 波长的一半，因此充当谐振器。它将微波无线耦合并将微波集中在间隙处，产生一个天线。空间中约 100 μm 的局域电场我们的科学前提基于非热神经。微波的抑制作用和SRR的共振作用使SRR产生集中。微波并允许神经调节超出微波衍射极限，空间达到约 100 μm 在拟议的工作中，我们将设计和制造具有优越精度的钛植入式 SRR。然后，我们将使用体外原代神经元验证 SRR 在神经抑制方面的潜力。通过完成所提出的研究，我们将开发出一种小鼠体内癫痫模型。生物相容性和可植入的神经调节装置提供的厘米级穿透深度。微波和 SRR 提供的亚毫米空间精度有望实现广泛的生物医学应用。对于中枢神经系统，我们的技术可以对神经系统进行微创经颅调节脑内活动和癫痫的临床治疗一个互补的多学科团队。汇集专门知识来实施拟议的活动。