GORDON CONFERENCE ON FIBRONECTIN, INTEGRINS & RELATED MA

纤维连接蛋白、整合素戈登会议

• 批准号: 2082809
• 负责人: Jean E Schwarzbauer
• 金额: $ 1.1万
• 依托单位: GORDON RESEARCH CONFERENCES
• 依托单位国家: 美国
• 财政年份: 1995
• 资助国家: 美国
• 起止时间: 1995-01-20 至 1995-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/2082809
• 关键词: cell adhesion molecules; fibronectins; integrins; meeting /conference /symposium; travel

Funds are requested for a Gordon Conference on fibronectin, integrins, and related macromolecules to meet in Oxnard, California, in February 1995. The paradigm of an extracellular adhesin, fibronectin interaction with a transmembrane receptor has proven applicable to a number of adhesion systems. There are several other extracellular glycoproteins with biological properties like fibronectin including laminin, thrombospondin, von Willebrand factor, fibrinogen/fibrin, vitronectin, and cytotactin/ tenascin/hexabrachion. The primary structures of each of these proteins are determined and three-dimensional structures are available for parts of some. This will open up new possibilities for studies of function. In parallel has come the realization that the transmembrane receptor for fibronectin is only one member of the integrin family of functionally related, homologous, cell adhesion receptors. Fibronectin and related macromolecules are involved in many basic functions of cells, including cell adhesion, determination of cell shape and differentiation, cell migration, cytoskeletal organization, and organization of extracellular matrix. Thus, fibronectin and the molecules with which it interacts are important in embryogenesis, connective tissue organization, hemostasis, thrombosis, wound healing, development of immunity, hematopoiesis, malignant transformation, and tumor metastasis. The challenges to the field over the next several years are to comprehend and organize the large amount of new structural information and design experiments based upon it; learn the relative biological importance of the several seemingly redundant adhesion systems; and apply the new insights to the treatment of human diseases. The 1995 Gordon Research Conference will serve as a valuable forum to present and discuss new information, identify problem areas, and plan new approaches.

要求资金参加有关纤连蛋白，整合素和整合素和的戈登会议 相关的大分子将于1995年2月在加利福尼亚州的奥克斯纳德会面。 细胞外粘着蛋白的范式，纤连蛋白与A的相互作用 跨膜受体已被证明适用于多种粘附 系统。还有其他几种细胞外糖蛋白 生物特性，例如纤连蛋白，包括层粘连蛋白，血小板传播， von willebrand因子，纤维蛋白原/纤维蛋白，玻璃体蛋白和细胞肌动蛋白/ Tenascin/Hexabrachion。这些蛋白质的主要结构 确定并适用于一部分的三维结构 一些。这将为研究功能研究开辟新的可能性。 在 并行意识到跨膜受体的 纤连蛋白在功能上仅是整联蛋白家族的一个成员 相关，同源，细胞粘附受体。 纤连蛋白及相关 大分子参与了许多细胞的基本功能，包括 细胞粘附，细胞形状和分化的测定，细胞 迁移，细胞骨架组织和细胞外的组织 矩阵。因此，纤连蛋白和与之相互作用的分子是 在胚胎发生，结缔组织组织，止血，重要 血栓形成，伤口愈合，免疫发育，造血，造血， 恶性转化和肿瘤转移。对 未来几年的领域将理解和组织大型 基于它的新结构信息和设计实验的数量； 了解几个看似的相对生物学重要性 冗余粘附系统；并将新见解应用于处理 人类疾病。 1995年戈登研究会议将成为 介绍和讨论新信息，确定问题的宝贵论坛 区域，并计划新方法。