FASEB Conference-Immunoreceptors

FASEB会议-免疫受体

• 批准号: 7000720
• 负责人: John C Cambier
• 金额: $ 2.25万
• 依托单位: FEDERATION OF AMER SOC FOR EXPER BIOLOGY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-06-01 至 2006-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7000720
• 关键词: antigen presentation; autoimmunity; biological signal transduction; immunologic receptors; inflammation; intermolecular interaction; meeting /conference /symposium; neoplasm /cancer; protein structure function; travel

DESCRIPTION (provided by applicant): Although their potential is far from being fully realized, cell surface receptors have proven to be very effective therapeutic targets in a variety of clinical settings. Effective biologicals and small molecules targeted to receptors appear to act by a variety of mechanisms ranging from receptor antagonists to induction of apoptosis, to targeting of cells for destruction by their innate immune system. To reach the full potential of this approach a more complete understanding of cell surface receptor structure-function relationships and signaling will be necessary. The progress toward this goal can be attained most rapidly when interactions among clinicians and scientists are maximized by focused conferences. We apply herein for NIH support of the 2005 FASEB conference on "Immunoreceptors" to be held in Tucson, Arizona July 23-28, 2005. The conference has evolved from a series of successful conferences held bi-annually since the early 1980's that originally focused on the question of immunoglobulin constant region (Fc) receptor function. In recent iterations, the scope of the meeting has broadened to consider function of other immune system receptors that contain lg-folds. The conference will bring together experts who, although they come from different disciplines, share interests in the family receptors including: molecular structure and how it informs function, role of these receptors in inflammation, signal transduction and exploitation in the clinic. Goals for the conference include fertilization across these disciplines and involvement of young, female and minority scientists in these research areas. Thus among the invited 33 speakers there will be 9 women and an additional 8 presentations will be solicited from young scientists who submit abstracts. Major themes will be 1) molecular structure-function, 2) intermolecular interactions and proximal signaling, 3) membrane domains, 4) immunological synapses, 5) inhibitory receptors and feedback loops and 6) clinical applications in inflammation, autoimmunity and cancer. This conference is structured to provide an optimal opportunity for cross-discipline interaction as well as a balanced treatise on the most contemporary and contentious problems in our field. Hopefully, it will nurture translational studies to develop therapeutic compounds targeted to cell surface molecules.

描述（由申请人提供）：尽管细胞表面受体的潜力远未完全实现，但已被证明在各种临床环境中是非常有效的治疗靶点。针对受体的有效生物制品和小分子似乎通过多种机制发挥作用，从受体拮抗剂到诱导细胞凋亡，再到通过先天免疫系统靶向细胞以进行破坏。为了充分发挥这种方法的潜力 有必要更全面地了解细胞表面受体的结构-功能关系和信号传导。当临床医生和科学家之间通过有针对性的会议最大化互动时，实现这一目标的进展可以最快地实现。我们在此申请 NIH 支持将于 2005 年 7 月 23-28 日在亚利桑那州图森举行的 2005 年 FASEB“免疫受体”会议。该会议是从 1980 年代初期以来每两年举行一次的一系列成功会议的基础上发展而来的，最初的重点是关于免疫球蛋白恒定区（Fc）受体功能的问题。在最近的迭代中，会议范围已扩大到考虑包含 lg 折叠的其他免疫系统受体的功能。会议将汇集来自不同学科的专家，他们对家族受体有着共同的兴趣，包括：分子结构及其如何影响功能、这些受体在炎症中的作用、信号转导和临床开发。会议的目标包括促进这些学科的发展，以及年轻、女性和少数族裔科学家参与这些研究领域。因此，在受邀的 33 名演讲者中，将有 9 名女性，另外还将向提交摘要的年轻科学家征集 8 场演讲。主要主题包括：1) 分子结构-功能，2) 分子间相互作用和近端信号传导，3) 膜域，4) 免疫突触，5) 抑制性受体和反馈环，6) 在炎症、自身免疫和癌症中的临床应用。这次会议的目的是为跨学科互动提供最佳机会，并就我们领域中最当代和最有争议的问题进行平衡的论述。希望它能够促进转化研究，开发针对细胞表面分子的治疗化合物。