Neurophysiology of Multisensory Integration

多感觉统合的神经生理学

• 批准号: 6745195
• 负责人: JOHN J FOXE
• 金额: $ 27.76万
• 依托单位: NATHAN S. KLINE INSTITUTE FOR PSYCH RES
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-06-01 至 2008-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6745195
• 关键词: attention; auditory stimulus; behavioral /social science research tag; bioimaging /biomedical imaging; brain electrical activity; brain imaging /visualization /scanning; clinical research; electrodes; evoked potentials; functional magnetic resonance imaging; human subject; motion perception; neural information processing; neurophysiology; sensation; sensory discrimination; sensory mechanism; sequential perception; somesthesis; sound perception; visual perception; visual stimulus

DESCRIPTION (provided by applicant): That the different senses sample unique aspects of physical objects should provide the brain with both a richer description of objects, and converging evidence concerning their position, identity and movement. Although there has been a detailed explication of multi sensory processing in the superior colliculus of cats and a number of multi sensory brain regions have been detailed in non-human primates, we have only a rudimentary understanding of how information from different sensory systems is combined in the human neo-cortex. The purpose of this proposal is to further our understanding of human cortical multi sensory integration through the combined use of event-related potential (ERP) recordings and functional imaging (fMRI). High-density mapping of ERPs recorded from 128 scalp electrodes, co-registration of these maps with individual subject MRI-derived anatomy, and source analysis of the surface recorded data will allow us to assess the brain regions involved in such integrations. Parallel fMRI experiments will allow us to precisely define the brain regions involved in a given multi sensory operation. Integration of ERP source-analyses and fMRI data will provide the spatio-temporal dynamics of multi sensory integration. Critically, the precise temporal resolution of the ERP will allow us to assess the time-course of multi sensory integration effects relative to the time-course of ongoing unisensory processing. We propose to determine: 1) the temporal separation parameters between the unisensory constituents of a bi-sensory audio-visual stimulus that result in modifications of the ERP interactions associated with bi-sensory stimulation, 2) whether spatial separation of bi-sensory stimuli modifies the early ERP interactions associated with bi-sensory stimulation, 3) whether top-down influences (attention) can effect the earliest multi-sensory interactions to bi-sensory stimulation, 4) to assess the effects of simultaneous stimulation in an entirely task-irrelevant sensory modality (vision) upon the ERP interactions with a second task-relevant sensory modality (somesthesis). Specifically, we wish to assess the effects of the irrelevant modality when it either contradicts or confirms task-relevant spatial information, 5) whether illusory changes in the perception of visual apparent motion, which are induced by presentation of simultaneous auditory stimuli, are the result of auditorily driven processing changes in visual motion processing areas. Through these studies, we will begin to explore the neural mechanisms underlying the process of "binding," related inputs across the separate sensory modalities.

描述（由申请人提供）：不同的感官对物理物体的独特方面进行采样，应该为大脑提供对物体更丰富的描述，并提供有关其位置、身份和运动的聚合证据。尽管对猫的上丘的多感觉处理进行了详细说明，并且对非人类灵长类动物的许多多感觉大脑区域进行了详细说明，但我们对如何将来自不同感觉系统的信息结合起来只有初步的了解。人类新皮质。该提案的目的是通过结合使用事件相关电位（ERP）记录和功能成像（fMRI）来进一步了解人类皮质多感觉整合。从 128 个头皮电极记录的 ERP 的高密度映射、这些映射与个体受试者 MRI 衍生的解剖结构的共同配准以及表面记录数据的源分析将使我们能够评估参与此类整合的大脑区域。并行功能磁共振成像实验将使我们能够精确定义参与给定多感官操作的大脑区域。 ERP 源分析和功能磁共振成像数据的集成将提供多感官集成的时空动态。至关重要的是，ERP 的精确时间分辨率将使我们能够评估多感觉统合效应相对于正在进行的单感觉处理的时间过程的时间过程。我们建议确定：1）双感觉视听刺激的单感觉成分之间的时间分离参数，导致与双感觉刺激相关的 ERP 相互作用的修改，2）双感觉刺激的空间分离是否会改变与双感觉刺激相关的早期 ERP 相互作用，3）自上而下的影响（注意力）是否可以影响双感觉刺激的最早多感觉相互作用，4）评估同时刺激的效果完全与任务无关的感觉模态（视觉）基于 ERP 与第二个任务相关的感觉模态（somesthesis）的相互作用。具体来说，我们希望评估不相关模态的影响，当它与任务相关的空间信息相矛盾或证实时，5）是否会导致由同时听觉刺激引起的视觉表观运动知觉的幻觉变化视觉运动处理区域中听觉驱动的处理变化。通过这些研究，我们将开始探索“结合”过程背后的神经机制，以及跨不同感觉模式的相关输入。