University of Rochester Intellectual and Developmental Disabilities Research Center

罗切斯特大学智力与发育障碍研究中心

基本信息

批准号：
10633122
负责人：
JOHN J FOXE
金额：
$ 122.87万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10633122
关键词：
Acceleration Adopted Advisory Committees Affect Amalgam Animal Behavior Architecture Area Articulation Automobile Driving Basic Science Biological Biology Brain Caring Catchment Area Child Clinic Clinical Clinical Investigator Clinical Research Clinical Sciences Clinical Services Collaborations Communication Communities Community Health Education Community Outreach Consultations Counseling Dedications Development Developmental Disabilities Diagnostic Procedure Disease Education and Outreach Educational workshop Ensure Evaluation Family Fostering Funding Goals Grant Health Personnel Heart Human Individual Infrastructure Institution Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Interdisciplinary Study Intervention Leadership Medical Medical center Medicine Mind Mission Modeling Morals Motion Multilingualism Neurosciences Neurosciences Research Online Systems Pathologic Pathway interactions Patients Pediatrics Persons Phenotype Philosophy Pilot Projects Population Positioning Attribute Program Sustainability Protocols documentation Psychology Publications Quality Control Recording of previous events Research Research Personnel Research Project Grants Scientist Services Spielmeyer-Vogt Disease Strategic Planning Stress Support Groups System Systems Integration Talents Technology Therapeutic Training Translational Research Universities Vision Work autism spectrum disorder base biopsychosocial cellular imaging clinical care clinically actionable college cost effectiveness cultural competence design early life exposure ethnic diversity expectation health disparity innovation insight interest lectures molecular imaging multisensory neurodevelopment neuroimaging neuroinflammation neurophysiology next generation novel diagnostics operation outreach prevent professor programs recruit service programs socioeconomics success translational neuroscience translational scientist

项目摘要

The University of Rochester (UR) has a long and extraordinarily rich history of providing first-rate clinical services to persons with Intellectual and Developmental Disabilities (IDD), and in driving new discoveries through research that create increased opportunity for individuals with IDD to live their lives to the fullest of their potential. This proposed UR-IDDRC is founded upon a revolutionary philosophy of medicine, first introduced here at UR Medical Center by Profs. George Engel and Jon Romano in 1977: The Biopsychosocial Model. This simple, yet profound idea, that the person seeking treatment is not merely a product of their biology, but rather, is also an amalgam of their psychology and socio-economic circumstances, places the whole person in all their complexity at the center of medicine. If ever there was a population that deserves to be recognized and treated in this holistic humanistic manner, it is those with an IDD. This UR-IDDRC places persons with IDD at the center of our inclusive neurodiverse mission, and commits to providing excellence in our basic, translational and clinical research, with a singular focus on providing tractable clinical solutions for these individuals. In the pages of this program application, we describe the Center’s crucial scientific infrastructure, which supports four cutting-edge Cores that elevate and accelerate the work of our 105 UR-IDDRC investigators, providing the very latest available technologies and expertise with high efficiency and excellent cost-effectiveness. These Cores are: Human Phenotyping & Recruitment (HPR); Translational Neuroimaging & Neurophysiology (TNN); Cell & Molecular Imaging (CMI); and Animal Behavior and Neurophysiology (ABN). Through vigorous leadership and in close consultation with our UR-IDDRC community and the five key advisory committees that provide counsel to our Administrative Core (ADM), we articulate a set of five research foci that embrace key and established research strengths at our institution while also seeking to expand our program into important areas of concern to the larger IDD community. These are: (1) Rare and orphaned diseases of neurodevelopment; (2) Parental stress and early life exposure as determinants of brain development; (3) Neuroinflammatory mechanisms in pathological brain development; (4) Autism spectrum disorder; (5) Multisensory and sensorimotor integration. Some 202 ongoing IDD projects, and 9 associated training grants, are supported by this infrastructure, and the Center Leadership is committed to further growing this already thriving program by attracting and training new young investigators and clinicians in IDD research. Major efforts to disseminate the work of the Center through media outlets and culturally competent multilingual publications, oriented at our community, are in place. Outreach to our IDD community and the public at large is a central concern of the UR-IDDRC. Leveraging the enormous financial commitment of the University of Rochester’s leadership to developing the UR-IDDRC, and through a philanthropy-driven annual pilot grant fund of $400,000, UR-IDDRC leadership is strongly positioned to prosecute an innovative transformative IDD research agenda over the proposed five-year term of this program.

罗切斯特大学（UR）拥有一流的临床服务历史悠久且非常丰富的历史给有智力和发育障碍的人（IDD），并通过研究为患有IDD的人提供了更多机会，使自己的生活充满潜力。该提议的UR-IDDRC建立在革命性的医学哲学上，最初是在Ur介绍的教授的医疗中心。乔治·恩格尔（George Engel）和乔恩·罗曼诺（Jon Romano），1977年：生物心理社会模型。这个简单，然而深刻的想法是，寻求治疗的人不仅是其生物学的产物，而且是他们的心理学和社会经济环境的融合，将整个人置于所有人的身上医学中心的复杂性。如果有一个人口应该得到认可和治疗以这种整体人文主义的方式，就是那些具有IDD的人。这个UR-IDDRC将患有IDD的人置于中心我们包容性神经多样的使命，并致力于在我们的基本，翻译和临床上提供卓越研究，重点是为这些个体提供可访问的临床解决方案。在此页面计划应用程序，我们描述了该中心的关键科学基础设施，该基础设施支持四个尖端提升和加速我们105个UR-IDDRC调查人员的工作的核心，提供了最新的可用的技术和专业知识，具有高效率和出色的成本效益。这些核心是：人类表型与招聘（HPR）；翻译神经影像学和神经生理学（TNN）；细胞＆分子成像（CMI）；以及动物行为和神经生理学（ABN）。通过有力的领导和与我们的UR-IDDRC社区和提供律师的五个主要咨询委员会的密切协商对于我们的行政核心（ADM），我们阐明了一组五个研究焦点我们机构的研究优势，同时也试图将我们的计划扩展到重要的关注领域到更大的IDD社区。这些是：（1）神经发育的罕见和孤立疾病；（2）父母压力和早期生命暴露是大脑发育的确定因素；（3）神经炎症机制病理大脑发育；（4）自闭症谱系障碍；（5）多感官和感觉运动积分。大约有202个正在进行的IDD项目和9项相关培训补助金得到了该基础设施的支持，中心领导致力于通过吸引和培训新的新计划进一步发展这个已经蓬勃发展的计划 IDD研究的年轻研究人员和临床医生。通过以我们社区为导向的媒体和具有文化胜任的多语言出版物已到位。向我们的IDD社区和整个公众推广是UR-IDDRC的主要关注点。利用罗切斯特大学领导人对开发UR-IDDRC的巨大财务承诺，以及通过慈善驱动的年度试点赠款基金40万美元，UR-IDDRC领导层的位置很强在该计划的五年期间起诉创新的IDD研究议程。

项目成果

期刊论文数量（50）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

A Model-Based Hierarchical Bayesian Approach to Sholl Analysis.

基于模型的 Sholl 分析的分层贝叶斯方法。

DOI：
10.1101/2023.01.23.525256
发表时间：
2023
期刊：
bioRxiv : the preprint server for biology
影响因子：
0
作者：
Vonkaenel,Erik;Feidler,Alexis;Lowery,Rebecca;Andersh,Katherine;Love,Tanzy;Majewska,Ania;McCall,MatthewN
通讯作者：
McCall,MatthewN

Resolution of impaired multisensory processing in autism and the cost of switching sensory modality.