University of Rochester Intellectual and Developmental Disabilities Research Center

罗切斯特大学智力与发育障碍研究中心

基本信息

批准号：
10633122
负责人：
JOHN J FOXE
金额：
$ 122.87万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10633122
关键词：
Acceleration Adopted Advisory Committees Affect Amalgam Animal Behavior Architecture Area Articulation Automobile Driving Basic Science Biological Biology Brain Caring Catchment Area Child Clinic Clinical Clinical Investigator Clinical Research Clinical Sciences Clinical Services Collaborations Communication Communities Community Health Education Community Outreach Consultations Counseling Dedications Development Developmental Disabilities Diagnostic Procedure Disease Education and Outreach Educational workshop Ensure Evaluation Family Fostering Funding Goals Grant Health Personnel Heart Human Individual Infrastructure Institution Intellectual and Developmental Disabilities Research Centers Intellectual functioning disability Interdisciplinary Study Intervention Leadership Medical Medical center Medicine Mind Mission Modeling Morals Motion Multilingualism Neurosciences Neurosciences Research Online Systems Pathologic Pathway interactions Patients Pediatrics Persons Phenotype Philosophy Pilot Projects Population Positioning Attribute Program Sustainability Protocols documentation Psychology Publications Quality Control Recording of previous events Research Research Personnel Research Project Grants Scientist Services Spielmeyer-Vogt Disease Strategic Planning Stress Support Groups System Systems Integration Talents Technology Therapeutic Training Translational Research Universities Vision Work autism spectrum disorder base biopsychosocial cellular imaging clinical care clinically actionable college cost effectiveness cultural competence design early life exposure ethnic diversity expectation health disparity innovation insight interest lectures molecular imaging multisensory neurodevelopment neuroimaging neuroinflammation neurophysiology next generation novel diagnostics operation outreach prevent professor programs recruit service programs socioeconomics success translational neuroscience translational scientist

项目摘要

The University of Rochester (UR) has a long and extraordinarily rich history of providing first-rate clinical services to persons with Intellectual and Developmental Disabilities (IDD), and in driving new discoveries through research that create increased opportunity for individuals with IDD to live their lives to the fullest of their potential. This proposed UR-IDDRC is founded upon a revolutionary philosophy of medicine, first introduced here at UR Medical Center by Profs. George Engel and Jon Romano in 1977: The Biopsychosocial Model. This simple, yet profound idea, that the person seeking treatment is not merely a product of their biology, but rather, is also an amalgam of their psychology and socio-economic circumstances, places the whole person in all their complexity at the center of medicine. If ever there was a population that deserves to be recognized and treated in this holistic humanistic manner, it is those with an IDD. This UR-IDDRC places persons with IDD at the center of our inclusive neurodiverse mission, and commits to providing excellence in our basic, translational and clinical research, with a singular focus on providing tractable clinical solutions for these individuals. In the pages of this program application, we describe the Center’s crucial scientific infrastructure, which supports four cutting-edge Cores that elevate and accelerate the work of our 105 UR-IDDRC investigators, providing the very latest available technologies and expertise with high efficiency and excellent cost-effectiveness. These Cores are: Human Phenotyping & Recruitment (HPR); Translational Neuroimaging & Neurophysiology (TNN); Cell & Molecular Imaging (CMI); and Animal Behavior and Neurophysiology (ABN). Through vigorous leadership and in close consultation with our UR-IDDRC community and the five key advisory committees that provide counsel to our Administrative Core (ADM), we articulate a set of five research foci that embrace key and established research strengths at our institution while also seeking to expand our program into important areas of concern to the larger IDD community. These are: (1) Rare and orphaned diseases of neurodevelopment; (2) Parental stress and early life exposure as determinants of brain development; (3) Neuroinflammatory mechanisms in pathological brain development; (4) Autism spectrum disorder; (5) Multisensory and sensorimotor integration. Some 202 ongoing IDD projects, and 9 associated training grants, are supported by this infrastructure, and the Center Leadership is committed to further growing this already thriving program by attracting and training new young investigators and clinicians in IDD research. Major efforts to disseminate the work of the Center through media outlets and culturally competent multilingual publications, oriented at our community, are in place. Outreach to our IDD community and the public at large is a central concern of the UR-IDDRC. Leveraging the enormous financial commitment of the University of Rochester’s leadership to developing the UR-IDDRC, and through a philanthropy-driven annual pilot grant fund of $400,000, UR-IDDRC leadership is strongly positioned to prosecute an innovative transformative IDD research agenda over the proposed five-year term of this program.

罗切斯特大学 (UR) 在提供一流的临床服务方面拥有悠久而丰富的历史为智力和发育障碍 (IDD) 人士提供帮助，并通过以下方式推动新发现研究为 IDD 患者创造更多机会，让他们充分发挥自己的潜力。 UR-IDDRC 提案建立在革命性的医学哲学之上，首次在 UR 引入乔治·恩格尔 (George Engel) 和乔恩·罗马诺 (Jon Romano) 教授在医学中心于 1977 年提出：生物心理社会模型。然而广泛的想法是，寻求治疗的人不仅仅是其生物学的产物，而且也是他们的心理和社会经济环境的结合，使整个人处于他们所有的状态医学中心的复杂性是否存在值得认可和治疗的人群。以这种整体人文主义的方式，UR-IDDDRC 将 IDD 患者置于中心位置。我们的包容性神经多样性使命，并致力于在我们的基础、转化和临床方面提供卓越的服务研究，重点是为这些人提供易于处理的临床解决方案。在计划申请中，我们描述了该中心的关键科学基础设施，它支持四个尖端提升和加速我们 105 名 UR-IDDRC 研究人员工作的核心，提供最新的具有高效率和卓越成本效益的可用技术和专业知识是：人类表型分析和招募（HPR）；转化神经影像和神经生理学（TNN）；分子成像（CMI）；以及动物行为和神经生理学（ABN）。与我们的 UR-IDDRC 社区以及提供咨询的五个主要咨询委员会密切协商对于我们的行政核心（ADM），我们阐明了一组五个研究重点，其中包括关键和既定的研究重点我们机构的研究优势，同时也寻求将我们的项目扩展到重要的关注领域对于更大的 IDD 群体来说，这些疾病是：(1) 罕见和孤儿神经发育疾病；(2) 父母遗传疾病； (3)神经炎症机制病理性大脑发育；（4）自闭症谱系障碍；（5）多感觉和感觉运动整合。该基础设施支持约 202 个正在进行的 IDD 项目以及 9 个相关培训补助金中心领导层致力于通过吸引和培训新人来进一步发展这个已经蓬勃发展的项目青年调查员和指挥员在 IDD 研究中做出了重大努力，通过该中心传播工作。面向我们社区的媒体机构和具有文化能力的多语言出版物已经到位。 UR-IDDRC 的核心关注点是向我们的 IDD 社区和广大公众进行宣传。罗切斯特大学领导层对发展 UR-IDDRC 的巨额财政承诺，以及通过慈善驱动的年度试点拨款 400,000 美元，UR-IDDDRC 的领导地位处于有利地位在该计划拟议的五年期限内将创新的变革性 IDD 研究议程定为犯罪。

项目成果

期刊论文数量（50）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Resolution of impaired multisensory processing in autism and the cost of switching sensory modality.

DOI：
10.1038/s42003-022-03519-1
发表时间：
2022-06-30
期刊：
Communications biology
影响因子：
5.9
作者：
通讯作者：

DOI：
10.1186/s13023-023-02985-y
发表时间：
2023-12-12
期刊：
Orphanet journal of rare diseases
影响因子：
3.7
作者：
通讯作者：

A Model-Based Hierarchical Bayesian Approach to Sholl Analysis.

基于模型的 Sholl 分析的分层贝叶斯方法。

DOI：
10.1101/2023.01.23.525256
发表时间：
2023
期刊：
bioRxiv : the preprint server for biology
影响因子：
0
作者：
Vonkaenel,Erik;Feidler,Alexis;Lowery,Rebecca;Andersh,Katherine;Love,Tanzy;Majewska,Ania;McCall,MatthewN
通讯作者：
McCall,MatthewN

Network size affects the complexity of activity in human iPSC-derived neuronal populations.

网络大小影响人类 iPSC 衍生神经元群体活动的复杂性。