Administrative Core

行政核心

基本信息

批准号：
10445280
负责人：
JOHN J FOXE
金额：
$ 21.4万
依托单位：
UNIVERSITY OF ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2020
资助国家：
美国
起止时间：
2020-08-01 至 2025-05-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10445280
关键词：
Advisory Committees Advocacy Animal Behavior Architecture Basic Science Brain Budgets Charge Clinical Clinical Research Communities Community Health Education Competence Consultations Core Facility Development Disease Educational Activities Educational workshop Ensure Environment Evaluation Event Evolution Eye Family Fostering Funding Funding Agency Future Grant Heart High Performance Computing Human Informatics Infrastructure Intellectual and Developmental Disabilities Research Centers International Kinesiology Knowledge Leadership Linguistics Mink Mission Modernization Morals Newsletter Parents Pathologic Persons Phenotype Policies Policy Maker Postdoctoral Fellow Quality Control Rare Diseases Reporting Research Research Activity Research Infrastructure Research Personnel Research Project Grants Resources Science Scientific Advances and Accomplishments Scientist Series System Technical Expertise Techniques Technology Training Translating Translational Research Universities Vision Work archive data autism spectrum disorder base cellular imaging community engagement cost effectiveness cultural competence data archive data sharing density design disability diversity and inclusion early life exposure early life stress experience federal policy high risk innovation insight member molecular imaging multisensory neurodevelopment neuroimaging neuroinflammation neurophysiology open data operation outreach postdoctoral investigator pre-doctoral predoctoral investigator prevent professor programs recruit social media symposium technology development

项目摘要

Project Summary: The Administrative Core (ADM) of this new University of Rochester (UR) IDDRC application serves as the main coordination hub of a fully integrated system of four scientific cores that support the crucial work of 105 UR-IDDRC investigators currently prosecuting 202 basic, translational and clinical research projects in the domain of IDD research. These cores are: Human Phenotyping & Recruitment (HPR); Translational Neuroimaging & Neurophysiology (TNN); Cell & Molecular Imaging (CMI); and Animal Behavior and Neurophysiology (ABN). The ADM Core brings together two international leaders in the field of IDD research, Professors John Foxe and Jonathan Mink, both with a wealth of complementary leadership experience, to coordinate and prosecute this effort. In consultation with the UR-IDDRC community, they have formulated a clear and progressive mission of excellence in IDD research, one that places the people we serve, those with an IDD, at the heart of our Center, and one that promotes equity, inclusion, diversity, and cultural/linguistic competence. The ADM leadership has identified five thematic research clusters that serve to coalesce our portfolio into a coherent well-articulated IDD program, and around which we will build our future. These are: (1) Rare & Orphaned Diseases of Neurodevelopment; (2) Parental Stress & Early Life Exposure as Determinants of Brain Development; (3) Neuroinflammatory Mechanisms in Pathological Brain Development; (4) Autism Spectrum Disorder; and (5) Multisensory & Sensorimotor Integration. The ADM coordinates a substantial pilot grant program, supported through extensive philanthropic efforts and substantial University support, distributing $400,000 per annum in a highly competitive program designed to promote high-risk high- return IDD projects. We have set in place an innovative system of educational activities for pre- and post- doctoral trainees, and a substantial dissemination effort that includes multiple online social media outlets (with closed captioning in Spanish, and ASL translators at live events), an effort that has been specifically designed to be consumable by the public. The ADM coordinates a major data archiving and sharing effort across the Cores, interfacing with the UR CTSI and leveraging our state-of-the-art Bio-Lab Informatics System (BLIS). The Core has established reportage and systematic assessments that continuously scrutinize and evaluate the functioning of the center, ensuring that efficiency and cost-effectiveness are maintained at the highest levels and that the Cores evolve to be fully responsive to changes in technology and systems. The ADM is supported by five key advisory committees that provide crucial input regarding ongoing functioning of the center. These are: (a) The Executive Committee; (b) The External Advisory Board; (c) The Parent and Community Advisory Board; (d) The Internal Advisory Board; and (e) The Core Facilities Management Committee. We stand committed to a clear-eyed purpose, that through our science, we will endeavor each and every day to remove impediments facing people with IDD that prevent them from living the healthiest, most fulfilling lives possible.

项目摘要：新罗切斯特大学 (UR) IDDRC 的行政核心 (ADM) 应用程序是由四个科学核心组成的完全集成系统的主要协调中心，支持 105 名 UR-IDDRC 研究人员目前正在起诉 202 名基础、转化和临床研究人员的重要工作 IDD 研究领域的研究项目。这些核心是：人类表型分析和招募（HPR）；转化神经影像学和神经生理学（TNN）；细胞与分子成像（CMI）；和动物行为和神经生理学（ABN）。 ADM Core 汇聚了 IDD 领域的两位国际领导者约翰·福克斯 (John Foxe) 教授和乔纳森·明克 (Jonathan Mink) 教授在研究方面具有丰富的互补性领导能力经验，以协调和开展这项工作。与 UR-IDDRC 社区协商后，他们制定了一项明确且不断进步的 IDD 研究卓越使命，该使命使我们的人员能够我们中心的核心是为那些拥有 IDD 的人提供服务，并促进公平、包容、多样性和文化/语言能力。 ADM 领导层确定了五个主题研究集群，旨在将我们的产品组合整合为一个连贯、清晰的 IDD 计划，我们将围绕该计划构建我们的未来。这些是： (1) 神经发育的罕见病和孤儿病； (2) 父母压力和早期生活暴露大脑发育的决定因素； (3) 大脑病理发育中的神经炎症机制； (4) 自闭症谱系障碍； (5) 多感觉和感觉运动整合。 ADM 协调大量的试点拨款计划，通过广泛的慈善努力和大量大学的支持支持，每年在一项竞争激烈的计划中分配 400,000 美元，旨在促进高风险高返回 IDD 项目。我们建立了一个创新的学前和学后教育活动体系。博士生实习生，以及大量的传播工作，包括多个在线社交媒体渠道（西班牙语隐藏式字幕和现场活动中的 ASL 翻译），这是一项专门设计的工作可供公众消费。 ADM 协调整个系统的主要数据归档和共享工作核心，与 UR CTSI 连接并利用我们最先进的生物实验室信息系统 (BLIS)。核心建立了报告文学和系统评估，不断审查和评估中心的运作，确保效率和成本效益保持在最高水平并且核心的发展能够充分响应技术和系统的变化。支持ADM 由五个主要咨询委员会负责，为中心的持续运作提供重要投入。这些是： (a) 执行委员会； (b) 外部顾问委员会； (c) 家长和社区咨询木板; (d) 内部顾问委员会； (e) 核心设施管理委员会。我们站着致力于一个明确的目标，即通过我们的科学，我们将每天努力消除智力障碍患者面临的障碍使他们无法过上最健康、最充实的生活。