Mayo Clinic SPORE in Pancreatic Cancer

梅奥诊所 SPORE 在胰腺癌中的应用

基本信息

批准号：
7279142
负责人：
GLORIA M. PETERSEN
金额：
$ 217.95万
依托单位：
MAYO CLINIC ROCHESTER
依托单位国家：
美国
项目类别：
财政年份：
2003
资助国家：
美国
起止时间：
2003-09-29 至 2008-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/7279142
关键词：
Advisory Committees Advocacy Animal Model Animals Apoptosis Archives Area Arizona Arts Attention Autologous Dendritic Cells BRCA2 Protein BRCA2 gene Basic Science Behavior Benzo(a)pyrene Biochemical Bioinformatics Biological Biological Assay Biological Markers Biology Biometry Biostatistics Core Blood Glucose Blood specimen Brain Breast Canada Cancer Cell Growth Cancer Center Cancer Control Cancer Patient Cancer cell line Candidate Disease Gene Carcinogens Caring Case-Control Studies Cell Cycle Arrest Cell Line Cell Proliferation Cell Proliferation Regulation Cell Survival Cells Cellular biology Cessation of life Chronic Disease Cisplatin/Gemcitabine Clinic Clinical Clinical Investigator Clinical Research Clinical Trials Clinical Trials Cooperative Group Code Cohort Studies Collaborations Collection Combined Vaccines Commit Communities Compatible Complement Complement component C5 Consent County Cytochrome P-450 CYP1A1 Cytochrome P-450 CYP2E1 Cytostatics DNA DNA Damage DNA Repair Data Data Analyses Data Collection Databases Depth Development Diabetes Mellitus Diagnosis Diffusion Discipline Disease Disruption Dose Early Diagnosis Effectiveness Elastases Elements Environment Epidemiologic Studies Epidemiologist Epidemiology Equipment and supply inventories Etiology Exhibits Faculty Family Family history of Family member Family-Based Registry Fasting Fostering Foundations Freezing Frequencies Friends Funding Future Gastroenterologist Gene Expression General Population Generations Genetic Genetic Polymorphism Genetic Transcription Genomics Genotype Glutathione S-Transferase Goals Growth Hand Health Personnel Hematologic Neoplasms Heterocyclic Amines Holly Home environment Housing Human Hyperglycemia Image Image Analysis Immunodeficient Mouse Immunohistochemistry Immunosuppression Immunotherapeutic agent Immunotherapy Individual Inherited Inpatients Institutes Institution Interest Group International Investigation Joints KRT19 gene Knockout Mice Knowledge Laboratories Laboratory Scientists Lead Leadership Light Location Lung Maintenance Malignant Neoplasms Malignant neoplasm of pancreas Manuscripts Meat Mediating Medical Record Linkage Medical Records Medical Surveillance Medicine Melissa Methods Mexico Minnesota Mission Mitomycin Molecular Molecular Epidemiology Mucin-1 Staining Method Mus Mutation NAD(P)H dehydrogenase (quinone) 1, human NQO1 gene National Cancer Institute Natural History Nature Nebraska Neoplasm Metastasis Nitrates Nitrites North Central Cancer Treatment Group Nude Mice Numbers Oncogenes Oncologist Outcome Outpatients PTGS2 gene Pancreas Pancreatic Adenocarcinoma Pancreatic Elastase Pancreatic carcinoma Pathogenesis Pathologist Pathology Pathway interactions Patients Phase Philosophy Physicians Pilot Projects Population Population Sciences Population Study Preparation Prevention Prevention approach Prevention program Prevention strategy Principal Investigator Probability Procedures Process Production Professional Education Property Proteins Proto-Oncogenes Protocols documentation Publications Quality Control Quality of life Questionnaires RNA Radiation Radiation Oncologist Radiation therapy Ras Signaling Pathway Records Recruitment Activity Registries Regulation Reproduction spores Research Research Design Research Infrastructure Research Personnel Research Project Grants Resource Sharing Resources Risk Risk Assessment Risk Factors Role SV40 T Antigens Sampling Scientist Screening for cancer Screening procedure Serum Shipping Ships Signal Pathway Signal Transduction Signaling Molecule Signs and Symptoms Site Site-Directed Mutagenesis Smoke Smoking Source Specimen Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization Staging Standards of Weights and Measures Stratification Study of serum Subcutaneous Tissue Supervision Support of Research Surface Surgeon Susceptibility Gene Symptoms System TP53 gene Teleconferences Testing Therapeutic Therapeutic immunosuppression Tissue Banks Tissue Expansion Tissues Title Toxic effect Transgenic Animals Transgenic Mice Transgenic Organisms Translating Translational Research Treatment Protocols Tumor Tissue Uncertainty United States United States National Institutes of Health Universities Vaccines Visit Work Xeno Xenograft Model Xenograft procedure abstracting adenoma angiogenesis anticancer research base cancer care cancer cell cancer genetics cancer therapy career celecoxib cell growth chemotherapeutic agent chemotherapy clinical application clinically relevant combinatorial concept cytotoxic data management design diabetic effectiveness research experience family structure feeding gastrointestinal gemcitabine genetic epidemiology genetic linkage analysis genetic pedigree genome wide association study health science research human NAT2 protein improved inhibitor/antagonist innovation insight interest member molecular domain mouse model mutant neoplastic neoplastic cell nitrate novel novel therapeutics oncology pancreas xenograft pancreatic neoplasm patient oriented patient registry pre-clinical preclinical study prevent prognostic programs research study response subcutaneous symposium tissue registry translational approach translational study tumor virtual

项目摘要

The proposed Mayo Clinic SPORE in Pancreatic Cancer will facilitate and promote research in pancreatic cancer that is highly likely to result in benefit to patients who currently have very little hope or treatment options. With a paucity of research in pancreatic cancer, our emphasis is on the discovery of novel mechanisms and pathways that will elucidate the etiology and pathogenesis of pancreatic carcinoma, which in turn can translate into strategies for prevention, early detection, and treatment. Led by senior pancreatic cancer researchers, our SPORE has a significant research and patient base. Annually, physicians at Mayo Clinic see approximately 450 patients with pancreatic cancer, which alone constitutes 1.5% of all pancreatic cancer cases in the United States. All of the proposed projects have a scientific base with a translational trajectory. Project #1 will provide one of the most definitive means to study the role of candidate genes and environment in the etiology of pancreatic adenocarcinoma. Project #2 will include both a retrospective cohort study to characterize the optimal criteria for screening diabetic patients with undiagnosed pancreatic cancer and identify markers that discriminate patients with diabetes mellitus that is apparently caused by pancreatic cancer. Project #3 will examine the mechanisms of action and role of Vavl protooncogene in pancreatic cancer. Project #4 will examine the role of the mechanism and role of the BRCA2 gene in pancreatic cancer. Project #5 will utilize transgenic animal models of pancreatic cancer to evaluate therapeutic combinations of vaccine, COX-2 inhibitors, and chemo/radiation. We will make particular efforts to encourage pilot studies that utilize the core resources to understand pancreatic cancer. Following a formal, rigorous review process, this SPORE will thus fund up to six developmental projects annually. We will support career development of junior faculty who will be expected to build independent programs in translational pancreatic cancer research. Four cores Administrative Core, Patient Registry and Biospecimens Core, Animal Models and Xenograft Core, and Biostatistics Core) will support the research projects. An External Advisory Committee and internal Scientific Advisory Committee will provide scientific input and guidance, and broad institutional support will enhance the infrastructure of this SPORE.

拟议的胰腺癌中梅奥诊所孢子将促进和促进胰腺癌研究，这极有可能对目前没有希望或治疗选择的患者受益。由于缺乏胰腺癌的研究，我们的重点是发现新型机制和途径，这些机制将阐明胰腺癌的病因和发病机理，这反过来又可以转化为预防，早期检测和治疗的策略。在高级胰腺癌研究人员的带领下，我们的孢子具有重要的研究和患者基础。每年，梅奥诊所的医生参见大约450例胰腺癌患者，仅占所有胰腺的1.5％美国的癌症病例。所有拟议的项目都有一个具有转化轨迹的科学基础。项目＃1将提供研究候选基因和环境在胰腺腺癌病因中的作用的最明确的手段之一。项目＃2将包括一项回顾性队列研究，以表征筛查未诊断胰腺癌糖尿病患者的最佳标准，并鉴定出显然是由胰腺癌引起的糖尿病患者的标记。项目＃3将检查Vavl原纪在胰腺癌中的作用机理和作用。项目＃4将研究BRCA2基因在胰腺癌中的机理和作用的作用。项目＃5将利用胰腺癌的转基因动物模型来评估疫苗，COX-2抑制剂和化学/辐射的治疗组合。我们将特别努力鼓励使用核心资源来了解胰腺癌的试点研究。经过正式严格的审查过程，该孢子每年将最多六个发展项目资助。我们将支持初级教师的职业发展，他们将有望在翻译胰腺癌研究中建立独立计划。四个核心行政核心，患者注册表和生物测量核心，动物模型和异种移植核心以及生物统计学核心将支持研究项目。外部咨询委员会和内部科学咨询委员会将提供科学意见和指导，广泛的机构支持将增强该孢子的基础设施。