Neurological Predictors of Aphasia Recovery

失语症恢复的神经学预测因素

• 批准号: 6690885
• 负责人: JULIUS FRIDRIKSSON
• 金额: $ 7.28万
• 依托单位: UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-08-01 至 2006-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6690885
• 关键词: aphasia; behavior test; bioimaging /biomedical imaging; brain circulation; cerebral ischemia /hypoxia; cerebrovascular imaging /visualization; clinical research; functional ability; human subject; magnetic resonance imaging; neurophysiology; prognosis; stroke

DESCRIPTION (provided by applicant): The long-term objective of this research is to increase understanding of the relationship between brain changes and behavioral recovery from stroke. Recent studies of the relationship between brain perfusion, lesion size, and early severity of aphasia (language disorder) in stroke suggest that these variables are strongly correlated. It is not clear, however, how changes in cerebral perfusion and lesion size may be related to behavioral recovery following stroke. MRI provides means for quick assessment of cerebral perfusion and lesion size in the acute stages of stroke. Along with behavioral testing, MRI makes it possible to investigate how changes in neurological factors are related to stroke recovery. The specific aims of this project are to answer the following questions: 1. Do changes in cerebral hypoperfusion and/or lesion size predict recovery from aphasia and hemispatial neglect during the first month following stroke. 2. Does the extent of cerebral hypoperfusion and/or lesion size in acute ischemic stroke predict recovery from aphasia and hemispatial neglect and clinical outcome at one-month post-onset? Answers to these questions will provide insight into how brain changes and behavioral recovery may be related in early stroke. Consequently, they provide means to improve management of early stroke and, subsequently, aphasia and hemispatial neglect. That is, if the extent of behavioral recovery can be predicted based on brain physiology in the acute care [stage?], it is possible that stroke treatment can be better calibrated.

描述（由申请人提供）：这项研究的长期目标是增加对大脑变化与中风行为恢复之间关系的理解。关于中风中失语症（语言障碍）的脑灌注，病变大小和早期严重程度之间关系之间关系的最新研究表明，这些变量密切相关。但是，尚不清楚脑灌注和病变大小的变化可能与中风后的行为恢复有关。 MRI提供了快速评估中风急性阶段脑灌注和病变大小的手段。除了行为测试外，MRI可以研究神经系统因素的变化与中风恢复有关。该项目的具体目的是回答以下问题：1。在中风后的第一个月中，脑部灌注不良和/或病变大小的变化可预测从失语症和半专业疏忽中恢复。 2。急性缺血性中风中脑灌注不足和/或病变大小的程度是否可以预测在发生后一个月发作的一个月中的失语和半部疏忽和临床结果中的恢复？这些问题的答案将为您的大脑变化和行为恢复如何在早期中风中相关。因此，它们提供了改善早期中风的管理的手段，随后是失语症和半专业的忽视。也就是说，如果可以基于急性护理中的脑生理来预测行为恢复的程度[阶段？]，则可能可以更好地校准中风治疗。