Neural Correlates of Aphasia Treatment and Recovery: fMRI Investigations

失语症治疗和恢复的神经相关性：功能磁共振成像研究

• 批准号: 6969670
• 负责人: CYNTHIA K THOMPSON
• 金额: $ 55.27万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2005
• 资助国家: 美国
• 起止时间: 2005-07-01 至 2010-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6969670
• 关键词: aphasia; behavior test; bioimaging /biomedical imaging; brain mapping; clinical research; frontal lobe /cortex; functional magnetic resonance imaging; human subject; human therapy evaluation; language; neuroimaging; neuropsychology; patient oriented research; perfusion; stroke; stroke therapy

DESCRIPTION (provided by applicant): The goal of the work described in this proposal is to provide a neuroimaging-based examination of the mechanisms of aphasia treatment and recovery. We propose to use functional magnetic resonance imaging together with structural and perfusion MR imaging as tools for tracking, recording and evaluating brain behavior changes linked to treatment-based changes in four experiments. We propose to systematically examine both behavioral and (correlated) neural effects of treatment while manipulating several critical patient-based and treatment-based variables that have been hypothesized to be relevant to aphasia recovery. The patient-related variables we will study include site and extent of lesion, in patients with anterior vs. posterior lesions, in early post-stroke vs. late post-stroke (chronic) stages of recovery. We propose to study the effects of treatment (vs. placebo-treatment) for these patients with a focus on both comprehension and production deficits in sentence level processing, comparing: two different treatment-intensity schedules (intensive vs. extended) and two different complexity-of-treatment conditions (training complex-to-simple vs. simple-to-complex structures). Our focus on this latter variable is based on our previous work showing that the former (complex-to-simple training) results in greater efficacy of treatment and generalization effects as compared to the latter. Additionally, we propose behavioral studies that extend examination of this 'complexity-of treatment' hypothesis into new domains of language processing and new populations (posteriorly lesioned patients with Wernicke's aphasia). Overall, we propose to employ (and replicate) treatment methods with previously demonstrated behavioral efficacy so as to provide a solid basis for examining (via neuroimaging) brain-based changes associated with a range of critical patient-based and treatment-based variables during treatment. Additionally, we propose to examine theoretically motivated extensions of the complexity method to new domains of language treatment.

描述（由申请人提供）：本提案中描述的工作的目的是提供基于神经成像的检查，对失语症治疗和恢复机制。我们建议将功能性磁共振成像与结构和灌注MR成像一起用作跟踪，记录和评估与四个实验中基于治疗的变化有关的脑行为变化的工具。我们建议系统地检查治疗的行为和（相关）神经效应，同时操纵几个关键的基于患者和基于治疗的变量，这些变量已假设与失语症恢复有关。我们将研究的与患者相关的变量包括病变的部位和病变范围，在前期病变的患者中，中风后与恢复后期（慢性）恢复阶段。我们建议研究这些患者的治疗（与安慰剂治疗）的影响，重点是句子水平处理中的理解和生产不足，比较：两种不同的治疗强度时间表（密集与扩展）和两种不同的治疗条件（训练复杂到简单到简单的简单到简单的与简单的结构）。我们对后一个变量的关注是基于我们先前的工作表明，与后者相比，前者（复杂到简单训练）会导致治疗和概括效应的更大功效。此外，我们提出了行为研究，将这种“复杂性”假设扩展到语言处理和新人群的新领域（后部病变患者Wernicke失语症）。总体而言，我们建议采用（并复制）治疗方法具有先前证明的行为疗效，以提供稳固的基础，以检查（通过神经成像）与一系列与一系列与一系列基于患者的关键患者和基于治疗的变量相关的大脑变化（通过神经成像）。此外，我们建议研究复杂性方法的理论动机扩展到新的语言处理领域。