Neurobiology of Language Recovery in Aphasia: Natural History and Treatment-Ind*

失语症语言恢复的神经生物学：自然史和治疗工业*

• 批准号: 8478376
• 负责人: CYNTHIA K THOMPSON
• 金额: $ 239.01万
• 依托单位: NORTHWESTERN UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2013
• 资助国家: 美国
• 起止时间: 2013-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/8478376
• 关键词: Acquired Dysgraphia; Address; Adult; Affect; Age; Agrammatism; Aphasia; Area; Attention; Behavioral; Biological Markers; Boston; Brain; Chronic; Clinical; Clinical Investigator; Clinical Research; Cognitive; Complex; Coupled; Data; Data Analyses; Deposition; Diffusion Magnetic Resonance Imaging; Disease; Educational Background; Functional Magnetic Resonance Imaging; Goals; Heart; Image; Impairment; Individual; Intervention; Knowledge; Language; Language Disorders; Lead; Learning; Lesion; Location; Measures; Methodology; Methods; Monitor; Names; Natural History; Neurobiology; Outcome; Outcome Measure; Performance; Perfusion; Process; Recovery; Research; Research Personnel; Rest; Severities; Signal Transduction; Site; Specialist; Stroke; TNFRSF5 gene; Testing; Thick; Time; Tissues; Universities; Work; Writing; aphasic; base; clinical practice; cognitive change; improved; innovation; interest; neuroimaging; novel; outcome forecast; procedural memory; programs; public health relevance; relating to nervous system; research study; response; social; therapy design; tool; treatment effect; white matter

DESCRIPTION (provided by applicant): This Clinical Research Center (P50) proposal is focused on providing a neuroimaging-based examination of language recovery in individuals with chronic aphasia resulting from stroke. The goal of the Center is to bring together the expertise of clinical investigators with mutual scientific interest and complementary expertise in understanding the cognitive and neural correlates of stroke-induced language recovery, the effects of language treatment on these processes, and cognitive and neural factors (biomarkers) of language/brain recovery. The proposal includes three subprojects, which examine language recovery in three language domains, with experts in each serving as PI: Subproject 1. The neurobiology of recovery of spoken naming in aphasia, Swathi Kiran (Boston University) and David Caplan (Harvard, MGH); Subproject 2. The neurobiology of recovery of written naming in acquired dysgraphia, Brenda Rapp (Johns Hopkins); and Subproject 3. The neurobiology of recovery of sentence processing in agrammatism, Cynthia Thompson (Northwestern). Combining the expertise and efforts of the PIs on this project will allow us to study aphasia recovery in a comprehensive manner. At the heart of the approach is a common set of cognitive and neuroimaging measures, including functional magnetic resonance imaging (fMRI), structural and perfusion imaging, and diffusion tensor imaging (DTI), which we will use as tools for identifying, monitoring and evaluating cognitive-brain changes at several time points, coinciding with treatment application and spanning a one-year period. Cross-project data will be deposited into a centralized Neuroimaging and Data Analysis Core (Core B) where they will be analyzed by an expert team of neuroimaging specialists and statisticians, led by Todd Parnsh (PI; neurophysicist at Northwestern), using state-of-the art neuroimaging acquisition and analysis methods. This will allow us to examine the effects of treatment designed to improve specific aphasic language deficits and to answer questions relevant to the relation between language and brain variables and treatment-induced versus natural recovery in chronic aphasia. The work will highly impact clinical intervention practices for individuals with aphasia, providing importan information relevant to the effects of treatment and prognosis for recovery, and contribute to knowledge about brain plasticity and the reorganization of language functions in the adult brain.

描述（由申请人提供）：该临床研究中心（P50）的提案旨在提供基于神经影像学对中风慢性失语症患者的语言恢复的检查。该中心的目的是将具有相互科学兴趣和互补专业知识的临床研究人员的专业知识汇集在一起​​，以理解中风引起的语言恢复的认知和神经相关性，语言治疗对这些过程的影响以及语言/大脑恢复的认知和神经因素（生物标志物）。该提案包括三个子弹，检查了三个语言领域中的语言恢复，每个专家都用作PI：subproject 1。大自语中的口语恢复神经生物学，Swathi Kiran，Swathi Kiran（波士顿大学）和David Caplan（Harvard，MGH，MGH）；副标题2。在获得的Dysgraphia，Brenda Rapp（Johns Hopkins）中恢复书面命名的神经生物学； 3。辛西娅·汤普森（辛西娅·汤普森（Cynthia Thompson）（西北），句子处理的恢复神经生物学。将PI在该项目上的专业知识和努力相结合将使我们能够以全面的方式研究失语症的恢复。该方法的核心是一组常见的认知和神经影像措施，包括功能磁共振成像（fMRI），结构和灌注成像以及扩散量张量成像（DTI），我们将用作识别，监测和评估几个时间点上的认知脑部变化的工具，以识别和评估一年的认知时间变化，并构成一年的一年，并跨越了一年的一年，并且跨度既有一年的时间均可识别。跨项目将存放在集中的神经影像学和数据分析核心（核心B）中，其中将由由Todd Parnsh（PI; Northwestern的神经物理学家）领导的神经成像专家和统计学家的专家团队进行分析，并使用Satate-Pate-the-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The-The Art Neuromimiganting Aquisition Aquisition和分析方法进行分析。这将使我们能够检查旨在改善特定失语语言缺陷的治疗的影响，并回答与语言与大脑变量之间的关系以及治疗引起的慢性失语症与自然恢复有关的问题。这项工作将对失语症的个体高度影响临床干预实践，从而提供与治疗和预后恢复的影响有关的重要信息，并有助于了解大脑可塑性以及对成人大脑中语言功能的重组。