SYNTHESES OF HIV RISK REDUCTION RESEARCH

降低艾滋病毒风险研究综述

• 批准号: 6392369
• 负责人: BLAIR T JOHNSON
• 金额: $ 21.01万
• 依托单位: UNIVERSITY OF CONNECTICUT STORRS
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-09-10 至 2002-11-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6392369
• 关键词: AIDS education /prevention; HIV infections; behavioral /social science research tag; clinical research; communicable disease transmission; condoms; disease /disorder proneness /risk; high risk behavior /lifestyle; human data; intravenous drug abuse; literature survey; meta analysis; outcomes research; safe sex /sex abstinence; sex behavior

DESCRIPTION (Applicant's Abstract): This revised application proposes to synthesize and organize existing knowledge regarding HIV transmission through behavior change. This synthesis will be achieved through a series of five theoretically guided and methodologically rigorous meta-analyses. The first three of these meta-analyses will directly address primary prevention of HIV infection, and the last two meta-analyses will focus on the theoretical basis for risky sexual behavior: (1) A first meta-analysis will synthesize studies regarding the efficacy of risk-reduction intervention for sexual transmission of HIV; (2) A second meta-analysis will synthesize studies that focused on the efficacy of risk-reduction interventions for HIV infection among intravenous drug users (IDUs); (3) A third meta-analysis will synthesize studies that focused on the efficacy of mass media intervention for HIV risk-reduction. The investigators expect that these meta-analyses will document the effectiveness of these risk reduction strategies and identify factors related to intervention success; (4) A fourth meta-analysis will synthesize studies testing the hypothesis that intention to use condoms correlate with condom usage; and (5) The fifth meta-analysis will synthesize intervention studies and examine whether changes in intention are associated with changes in behavior. By carefully summing up the evidence to date on these important and quickly growing literatures, these meta-analyses will inform public health officials, community-based interventionists, and scientists about which interventions work best, which components of interventions have the largest impact, and the circumstances under which HIV risk-reduction interventions are most likely to be successful.

描述（申请人的摘要）：本修订后的申请建议 综合和组织有关艾滋病毒传播的现有知识 通过行为改变。 这种综合将通过一系列 五项理论指导和方法论严格的荟萃分析。 这些荟萃分析中的前三个将直接解决主要问题 预防艾滋病毒感染，最后两项荟萃分析将重点关注 危险性行为的理论基础：（1）第一个荟萃分析 将综合有关降低风险功效的研究 干预艾滋病毒的性传播； (2) 第二次荟萃分析 综合关注降低风险功效的研究 针对静脉吸毒者（IDU）中艾滋病毒感染的干预措施； （3）A 第三项荟萃分析将综合关注以下功效的研究： 大众媒体干预降低艾滋病毒风险。 调查人员预计 这些荟萃分析将记录这些风险的有效性 减少策略并确定与干预成功相关的因素； (4) 第四项荟萃分析将综合检验假设的研究 使用安全套的意愿与安全套的使用相关； (5)第五个 荟萃分析将综合干预研究并检查是否 意图的改变与行为的改变相关。 通过仔细 总结迄今为止关于这些重要且快速增长的证据 文献，这些荟萃分析将为公共卫生官员提供信息， 基于社区的干预主义者以及关于哪些干预措施的科学家 效果最好，干预措施的哪些组成部分影响最大，以及 艾滋病毒风险降低干预措施最有效的情况 可能会成功。