Multiple HIV Prevention Packages for IDUs in Estonia

爱沙尼亚为注射吸毒者提供多种艾滋病毒预防方案

• 批准号: 7680539
• 负责人: Don C Des Jarlais
• 金额: $ 77.92万
• 依托单位: BETH ISRAEL MEDICAL CTR (NEW YORK)
• 依托单位国家: 美国
• 财政年份: 2009
• 资助国家: 美国
• 起止时间: 2009-06-08 至 2013-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7680539
• 关键词: AIDS prevention; AIDS/HIV problem; Address; Adherence; Area; Arts; Automobile Driving; Behavior; Behavior Therapy; Collaborations; Communities; Country; Developed Countries; Developing Countries; Drug abuse; Drug usage; Eastern Europe; Effectiveness; Epidemic; Estonia; Financial compensation; Future; Goals; HIV; HIV Infections; HIV Seroprevalence; Heterosexuals; Incidence; Individual; Injecting drug user; Intervention; Knowledge; Low income; Meta-Analysis; Methods; Modeling; Monitor; Needle Sharing; Persons; Pharmacologic Substance; Pilot Projects; Policies; Population; Prevalence; Prevention; Prevention program; Public Health; Reporting; Research; Risk; Risk Assessment; Risk Behaviors; Screening procedure; Seroprevalences; Sexual Partners; Sexual Transmission; Sexually Transmitted Diseases; Signal Transduction; Southern Asia; Specific qualifier value; Substance abuse problem; Syringes; Testing; Treatment Protocols; Update; Woman; Work; condoms; design; high risk; improved; intervention effect; motivational enhancement therapy; non-drug; prevent; programs; psychologic; response; sex risk; sexually active; social; systematic review; transmission process

DESCRIPTION (provided by applicant): High seroprevalence epidemics among IDUs pose two critical inter-related questions for public health: how to halt ongoing HIV transmission among IDUs and how to halt the transition from a concentrated IDU epidemic to a generalized heterosexual epidemic. While there are several interventions that have been shown effective in reducing risk behavior among IDUs, no single intervention is effective for all IDUs. Thus, these inter-related problems provide an ideal context for studying combinations of prevention programs. There are five Specific Aims in the proposed research: 1.Conduct systematic reviews of social structural and behavioral interventions to reduce injecting and sexual risk behavior, and biomedical interventions (drug abuse treatment, STI treatment) to reduce risk behavior among injecting drug users, and interventions to build community and policy support for HIV prevention among IDUs. For interventions with previous systeml interventions to reduce injecting and sexual risk behaviors among IDUs and of combinations of interventions at different levels of coverage, including optimization strategies for reducing HIV transmission among IDUs and from IDUs to non-drug using sexual partners 3. Monitor the ongoing high seroprevalence HIV epidemics among IDUs in Tallinn, Estonia to assess current interventions and model an "optimal" set of interventions for that epidemic. HIV prevalence is currently over 50% among IDUs in Tallinn, estimated incidence is over 20/100 person-years at risk and IDUs report high rates of multiple sexual partnerships with inconsistent condom use. 4. Conduct a pilot study of screening and treatment for sexually transmitted infections (STIs) among IDUs in Tallinn to assess feasibility and effectiveness in reducing sexual transmission among IDUs and from IDUs to non-drug injecting sexual partners. The pilot study will include biomedical intervention (screening and treatment) with a state-o transmission from IDUs to non-drug injecting sexual partners are two critical public health problems in many different countries. These inter-related problems are an ideal context for studying the effects of combined HIV prevention programs. Public health significance: Reducing HIV transmission among IDUs and preventing transmission from IDUs to non-drug injecting sexual partners are two critical public health problems in many different countries. These inter-related problems are an ideal context for studying the effects of combined HIV prevention programs.

描述（由申请人提供）： IDU中的高血清阳性流行病对公共卫生提出了两个关键的相关问题：如何停止IDU之间的持续HIV传播以及如何停止从集中的IDU流行病到广义异性恋流行病的过渡。尽管已经有几种干预措施有效地减少IDU的风险行为有效，但没有任何单一干预对所有IDU有效。因此，这些相互关联的问题为研究预防计划组合提供了理想的背景。拟议的研究中有五个具体的目的：1。对社会结构和行为干预的系统审查，以减少注射和性风险行为，以及生物医学干预措施（药物滥用治疗，STI治疗），以减少对吸毒者注入风险行为的风险行为，以及为IDUS中的艾滋病毒预防建立社区和政策支持的干预措施。为了进行以前的系统干预措施，以减少IDU之间的注入和性风险行为以及在不同级别的覆盖范围内干预措施的组合，包括优化策略，以减少IDU的艾滋病毒传播以及使用性伴侣之间的IDU和非毒品之间的iDus之间的传播以及使用性伴侣的非毒品到非毒品。那个流行病。艾滋病毒患病率目前在塔林的IDU中超过50％，估计的发病率超过20/100人口，IDUS报告了多种性伙伴关系的高率，使用避孕套不一致。 4.对塔林的IDU进行性传播感染（STI）进行筛查和治疗的试点研究，以评估降低IDUS以及从IDU，从IDU到非药物注入性伴侣的可行性和有效性。试点研究将包括生物医学干预措施（筛查和治疗），从IDU到非药物注射性伴侣的状态-O传播是在许多不同国家的两个关键公共卫生问题。这些相互关联的问题是研究联合艾滋病毒预防计划的影响的理想背景。公共卫生的意义：在许多不同国家，减少IDU之间的HIV传播并防止从IDU到非药物注入性伴侣的传播是两个关键的公共卫生问题。这些相互关联的问题是研究联合艾滋病毒预防计划的影响的理想背景。