Behavioral Economic Analysis of Polydrug Abuse

多种药物滥用的行为经济学分析

• 批准号: 6610560
• 负责人: GAIL D WINGER
• 金额: $ 43.26万
• 依托单位: UNIVERSITY OF MICHIGAN AT ANN ARBOR
• 依托单位国家: 美国
• 财政年份: 2003
• 资助国家: 美国
• 起止时间: 2003-04-10 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6610560
• 关键词: 3,4 methylenedioxymethamphetamine; Macaca mulatta; behavioral /social science research tag; choice; cocaine; craving; disease /disorder model; ethanol; methamphetamine; midazolam; nicotine; piperidine; preference; reinforcer; substance abuse related behavior; substance abuse related disorder; visual stimulus

DESCRIPTION (provided by applicant): Behavioral economic analysis of normalized demand functions is proving to be a useful way to quantify and compare drugs as reinforcers. Demand and response output functions generate two numbers, Pmax and Omax, both of which incorporate scheduled dose and response requirement variables, and likely reflect important aspects of the reinforcing effects of the drug. Because the reinforcing effects of drugs are probably related to their abuse liability in humans, these metrics may allow us to evaluate this aspect of the relative abuse liability of drugs more completely than we can do with most other procedures. The current proposal has as one of its aims the further use and development of the behavioral economic analysis of drugs as reinforcers in rhesus monkey models of i.v. drug-reinforced responding. In particular, the analyses will evaluate the relative reinforcing effects of a number of drugs of abuse using own-price elasticity of demand, will determine how the reinforcing effects of some drugs are modified when these drugs are combined with a second drug of abuse, and will measure demand functions when the animals can choose between two drug options using cross-price elasticity of demand. These latter two studies will provide information about types of polydrug use that are likely to occur commonly in human drug abusers, yet about which we have little data and few ways to study. The results should provide information about some of the behavioral and pharmacological mechanisms that lead people to take drugs simultaneously, or that direct their choice when more than one drug is available. We anticipate that these studies will help to identify and quantify important aspects of drug-seeking and drug-taking behavior and will put us in a better position to understand how these aspects control this behavior and what they might signify for intervention and treatment.

描述（由申请人提供）：事实证明，归一化需求功能的行为经济分析是量化和比较药物作为增强剂的有用方法。需求和响应输出功能产生了两个数字，PMAX和OMAX，两者都包含计划的剂量和响应需求变量，并且可能反映了药物增强作用的重要方面。 由于药物的加强作用可能与它们在人类中的虐待责任有关，因此这些指标可能使我们能够比我们大多数其他程序更全面地评估药物的相对滥用责任。当前的提案是其目标之一，是对恒河猴模型中的增强剂的行为经济分析的进一步使用和发展。毒品增强的反应。 特别是，分析将使用自己的价格弹性评估多种滥用药物的相对增强作用，将确定当这些药物与第二种滥用药物结合使用时，如何修改某些药物的增强作用，并在使用交叉价格弹性需求的两种药物期权之间进行衡量需求功能。后两项研究将提供有关多药物使用类型的信息，这些信息可能通常发生在人类滥用者中，但我们几乎没有数据和很少的研究方法。结果应提供有关导致人们同时服用药物的某些行为和药理机制的信息，或者在有多种药物可用时指导他们的选择。我们预计，这些研究将有助于识别和量化寻求毒品和吸毒行为的重要方面，并将使我们更好地了解这些方面如何控制这一行为以及它们可能对干预和治疗表示什么。