Psychostimulant-Induced Craving and Toxicity

精神兴奋剂引起的渴望和毒性

• 批准号: 7103192
• 负责人: Robert Christopher Pierce
• 金额: $ 11.03万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7103192
• 关键词: 3,4 methylenedioxymethamphetamine; Macaca mulatta; behavioral /social science research tag; central nervous system stimulants; cocaine; craving; disease /disorder model; dopamine; drug abuse; frontal lobe /cortex; gray matter; laboratory rat; model design /development; neurotransmitter transport; perfusion; substance abuse related behavior; white matter

DESCRIPTION (provided by applicant): This application is a K02 Independent Scientist Career Development Award submitted by R. Christopher Pierce, Ph.D. There are five major goals of the career development plan, which include: i) focusing more attention on Dr. Pierce's primary research program (funded by R01 DA15214, R.C. Pierce, PI), which is concentrated on delineating the neurochemical and biochemical changes in various limbic nuclei responsible for the reinstatement of cocaine-induced drug seeking; ii) increasing the scope of these studies to include imaging experiments in non-human primate subjects in order to evaluate changes in the CNS prior to, during and after periods of excessive cocaine intake; iii) learning the technical and methodological details associated with magnetic resonance imaging and magnetic resonance spectroscopy experiments, which will be required to complete the second goal. Goals ii and iii will be done in collaboration with Drs. James Rowlett and Itamar Ronen; iv) expanding Dr. Pierce's research program from a relatively single-minded focus on the behavioral pharmacology of cocaine to include issues related to the neurotoxicity produced by other drugs of abuse. Specifically, he will determine the functional consequences of MDMA-induced damage of central serotonin systems as well as potential toxic interactions between cocaine and MDMA; and v) learning new techniques from Dr. Bryan Yamamoto and Dr. Jean-Jacques Soghomonian related to measures of neurotoxicity (i.e. measures of free radical formation, lipid and protein oxidation, excitoxicity and terminal degradation) in the context of the MDMA-cocaine project. Dr. Pierce currently devotes 60% effort to research and 40% effort to teaching and administrative duties. If this application is funded, he will be released from 25% of his non-research duties such that 85% of his time will be devoted to research. This release time will allow Dr. Pierce to devote more attention to his existing research and also expand his research collaborations with Drs. Rowlett, Ronen, Yamamoto and Soghomonian, which will have a significant positive impact on his career development.

描述（由申请人提供）：此申请是R. Christopher Pierce博士提交的K02独立科学家职业发展奖。职业发展计划的五个主要目标包括：i）将更多注意力集中在皮尔斯博士的主要研究计划上（由R01 DA15214资助，R.C。Pierce，PI），该计划集中于划定各种Limbic Nuclei的神经化学和生物化学变化，负责将各种limbic nuclei恢复原状，负责恢复cocaine drugs-drugs indecain诱导的药物诱导的; ii）增加了这些研究的范围，以包括非人类灵长类动物受试者的成像实验，以评估过度可卡因摄入过度摄入之前，之中和之后的中枢神经系统的变化； iii）学习与磁共振成像和磁共振光谱实验相关的技术和方法学细节，这是完成第二个目标所必需的。目标II和III将与DRS合作完成。 James Rowlett和Itamar Ronen； iv）将皮尔斯博士的研究计划从可卡因的行为药理学的相对关注的关注中扩展，包括与其他滥用药物产生的神经毒性有关的问题。具体而言，他将确定MDMA诱导的中枢5-羟色胺系统损伤以及可卡因与MDMA之间的潜在有毒相互作用的功能后果。和v）从Bryan Yamamoto博士和Jean-Jacques Soghomonian博士学习与神经毒性测量有关的新技术（即，在MDMA-Cocaine项目的上下文中，自由基形成，脂质和蛋白质氧化，兴奋性和极端降解的自由基形成，脂质和蛋白质氧化）的方法。皮尔斯博士目前将60％的努力和40％的努力致力于教学和行政职责。如果该申请是资助的，他将从其非研究职责的25％中获释，以使他的85％的时间将用于研究。这个发布时间将使皮尔斯博士更加关注他的现有研究，并扩大他与Drs的研究合作。 Rowlett，Ronen，Yamamoto和Soghomonian将对他的职业发展产生重大积极影响。