Psychostimulant-Induced Craving and Toxicity

精神兴奋剂引起的渴望和毒性

• 批准号: 7103192
• 负责人: Robert Christopher Pierce
• 金额: $ 11.03万
• 依托单位: BOSTON UNIVERSITY MEDICAL CAMPUS
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-04-01 至 2011-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7103192
• 关键词: 3,4 methylenedioxymethamphetamine; Macaca mulatta; behavioral /social science research tag; central nervous system stimulants; cocaine; craving; disease /disorder model; dopamine; drug abuse; frontal lobe /cortex; gray matter; laboratory rat; model design /development; neurotransmitter transport; perfusion; substance abuse related behavior; white matter

DESCRIPTION (provided by applicant): This application is a K02 Independent Scientist Career Development Award submitted by R. Christopher Pierce, Ph.D. There are five major goals of the career development plan, which include: i) focusing more attention on Dr. Pierce's primary research program (funded by R01 DA15214, R.C. Pierce, PI), which is concentrated on delineating the neurochemical and biochemical changes in various limbic nuclei responsible for the reinstatement of cocaine-induced drug seeking; ii) increasing the scope of these studies to include imaging experiments in non-human primate subjects in order to evaluate changes in the CNS prior to, during and after periods of excessive cocaine intake; iii) learning the technical and methodological details associated with magnetic resonance imaging and magnetic resonance spectroscopy experiments, which will be required to complete the second goal. Goals ii and iii will be done in collaboration with Drs. James Rowlett and Itamar Ronen; iv) expanding Dr. Pierce's research program from a relatively single-minded focus on the behavioral pharmacology of cocaine to include issues related to the neurotoxicity produced by other drugs of abuse. Specifically, he will determine the functional consequences of MDMA-induced damage of central serotonin systems as well as potential toxic interactions between cocaine and MDMA; and v) learning new techniques from Dr. Bryan Yamamoto and Dr. Jean-Jacques Soghomonian related to measures of neurotoxicity (i.e. measures of free radical formation, lipid and protein oxidation, excitoxicity and terminal degradation) in the context of the MDMA-cocaine project. Dr. Pierce currently devotes 60% effort to research and 40% effort to teaching and administrative duties. If this application is funded, he will be released from 25% of his non-research duties such that 85% of his time will be devoted to research. This release time will allow Dr. Pierce to devote more attention to his existing research and also expand his research collaborations with Drs. Rowlett, Ronen, Yamamoto and Soghomonian, which will have a significant positive impact on his career development.

描述（由申请人提供）：本申请是 R. Christopher Pierce 博士提交的 K02 独立科学家职业发展奖。职业发展计划有五个主要目标，其中包括： i) 更加关注 Pierce 博士的主要研究项目（由 R01 DA15214，R.C. Pierce，PI 资助），该项目集中描绘各种神经化学和生化变化。边缘核负责恢复可卡因诱导的药物寻求； ii) 扩大这些研究的范围，纳入非人类灵长类动物受试者的成像实验，以评估过量可卡因摄入之前、期间和之后中枢神经系统的变化； iii) 学习与磁共振成像和磁共振波谱实验相关的技术和方法细节，这是完成第二个目标所需的。目标 ii 和 iii 将与 Drs 合作完成。詹姆斯·罗利特和伊塔玛·罗南； iv) 将皮尔斯博士的研究计划从相对单一的可卡因行为药理学重点扩展到与其他滥用药物产生的神经毒性相关的问题。具体来说，他将确定 MDMA 引起的中枢血清素系统损伤的功能后果，以及可卡因和 MDMA 之间潜在的毒性相互作用； v) 向 Bryan Yamamoto 博士和 Jean-Jacques Soghomonian 博士学习 MDMA-可卡因项目中与神经毒性测量（即自由基形成、脂质和蛋白质氧化、兴奋毒性和最终降解的测量）相关的新技术。 Pierce 博士目前将 60% 的精力投入到研究上，40% 的精力投入到教学和行政工作中。如果这项申请获得资助，他将免除 25% 的非研究职责，这样他的 85% 的时间将用于研究。这次发布时间将使皮尔斯博士能够更加关注他现有的研究，并扩大他与 Drs. 的研究合作。罗莱特、罗南、山本和索格莫尼安，这将对他的职业发展产生重大的积极影响。