SCREENING FOR OVARIAN CANCER--PSYCHOBEHAVIORAL OUTCOMES

卵巢癌筛查——心理行为结果

• 批准号: 6633553
• 负责人: MICHAEL A. ANDRYKOWSKI
• 金额: $ 14.63万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2004-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6633553
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; clinical research; cognition; coping; emotions; female; human subject; longitudinal human study; mass screening; neoplasm /cancer diagnosis; outcomes research; ovary neoplasms; psychological aspect of cancer; ultrasonography

Early detection of ovarian cancer (OC) is critical to management of the disease. While transvaginal sonography (TVS) is the preferred screening modality for OC, concerns have been raised regarding the cost/benefit ratio associated with TVS. While TVS has been shown to facilitate early detection of OC, TVS yields a high proportion of "abnormal" findings. These findings require additional follow-up in the form of repeat TVS testing or exploratory surgery. While the vast majority of these abnormal findings are ultimately determined to be "false positives," the impact of this potentiallly stressful experience upon a woman's cognition, affect, and behavior has not been adequately examined. This study will use a prospective, longitudinal design to examine psychological and behavioral outcomes associated with TVS screening for OC. Three groups of women will be studied: women undergoing an initial TVS test who receive a normal result (n=300), women undergoing an initial TVS test who receive an abnormal result (n=300), and a matched group of healthy women who have never undergone TVS testing (n=300). Assessments will be conducted prior to initial TVS test and at 2 week, and 4, 18, and 30 month followups. Guided by the conceptual framework provided by both the Cognitive-Social Health Information Processing (C-SHIP) and Monitoring Process Models, endpoints to be examined include cognition (e.g., risk perception, perceptions of TVS efficacy, intrusive and avoidant ideation), affect (e.g., depression, mood disturbance), and behavior (adherence to routine follow-up TVS testing). Research aims include: (1) characterization of women who undergo TVS screening; (2) identification of psychological and behavioral outcomes associated with TVS screening; and (3) identification of clinical, demographic, and psychological variables associated with post-TVS psychological and behavioral outcomes. Regarding the latter aim, hypotheses regarding the relationship between informational coping style (e.g., high monitoring) and post-TVS psychological and behavioral outcomes will be tested. Results will enable development of interventions to enhance psychological and behavioral outcomes after TVS screening for OC.

卵巢癌（OC）的早期发现对于疾病的治疗至关重要。虽然经阴道超声检查 (TVS) 是 OC 的首选筛查方式，但人们对 TVS 相关的成本/效益比表示担忧。 虽然 TVS 已被证明有助于早期检测 OC，但 TVS 产生的“异常”结果比例很高。这些发现需要以重复 TVS 测试或探查手术的形式进行额外的随访。 虽然这些异常发现中的绝大多数最终被确定为“误报”，但这种潜在压力经历对女性认知、情感和行为的影响尚未得到充分研究。本研究将采用前瞻性纵向设计来检查与 TVS 筛查 OC 相关的心理和行为结果。 将研究三组​​女性：接受初始 TVS 测试并获得正常结果的女性 (n=300)、接受初始 TVS 测试并获得异常结果的女性 (n=300) 以及对照组健康女性从未接受过 TVS 测试 (n=300)。 评估将在初次 TVS 测试之前以及 2 周、4、18 和 30 个月的随访时进行。在认知社会健康信息处理 (C-SHIP) 和监测过程模型提供的概念框架的指导下，要检查的终点包括认知（例如，风险感知、TVS 功效感知、侵入性和回避性意念）、情感（例如，抑郁、情绪障碍）和行为（遵守常规后续 TVS 测试）。 研究目标包括：(1) 接受 TVS 筛查的女性特征； (2) 确定与 TVS 筛查相关的心理和行为结果； (3) 识别与 TVS 后心理和行为结果相关的临床、人口统计和心理变量。 关于后一个目标，将测试有关信息应对方式（例如高度监控）与 TVS 后心理和行为结果之间关系的假设。 结果将有助于开发干预措施，以增强 TVS 筛查 OC 后的心理和行为结果。