Screening for Ovarian Cancer: Psychobehavioral Outcomes

卵巢癌筛查：心理行为结果

• 批准号: 7118907
• 负责人: MICHAEL A. ANDRYKOWSKI
• 金额: $ 17.08万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2008-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7118907
• 关键词: behavior test; behavioral /social science research tag; cancer risk; clinical research; cognition; diagnostic tests; education evaluation /planning; emotions; human subject; interview; longitudinal human study; neoplasm /cancer diagnosis; neoplasm /cancer education; neuropsychological tests; ovary neoplasms; perception; psychological aspect of cancer; questionnaires; social psychology; stress; ultrasonography; vagina; women' s health

DESCRIPTION (provided by applicant): Transvaginal sonography (TVS) can facilitate early detection of ovarian cancer (OC), however, like all cancer screening tests, TVS yields a proportion of "abnormal" findings. While the vast majority of abnormal TVS results are benign, the impact of this potentially stressful screening experience upon affective, cognitive, and behavioral outcomes has not been adequately examined. The proposed research builds on our current study (R01 CA84036) of psychological and behavioral outcomes associated with routine TVS screening by focusing explicitly on the impact of an abnormal TVS result. Women (n=400) receiving an abnormal TVS result during routine screening (Abnormal Screening (AS) group) and returning for a repeat TVS test four-eight weeks later will be matched (age, prior screening history) with women (n=400) receiving a normal TVS result during routine screening (Routine Screening (RS) group). All women will complete a baseline assessment prior to either routine (RS group) or repeat (AS group) TVS screening and follow-up assessments 1,4, and 18 months post-baseline. Some women (n=120) in the AS group will complete an additional "true" baseline assessment prior to the routine TVS test yielding their abnormal result. Measures of dispositional variables (optimism, monitoring, emotional approach coping) are obtained at baseline and affective (e.g., OC-specific distress), cognitive (e.g., OC risk perception, TVS efficacy beliefs, benefit finding), and behavioral (e.g., OC-specific monitoring behavior, emotional approach coping, participation in screening for breast/colon cancers) endpoints will be assessed longitudinally. Adherence with recommendations for routine TVS screening will be monitored by OC screening program records. Several contemporary theoretical models of response to stressful events (Cognitive-Social Health Information Processing, Monitoring Process, Social-Cognitive Processing) guide selection of study variables and provide specific hypotheses for testing. Three specific aims will be addressed: (1) characterize the impact of an abnormal TVS result with regard to the nature, magnitude, valence, and trajectory of outcomes; (2) identify clinical, demographic, dispositional, and psychosocial variables associated with magnitude and persistence of these outcomes; and (3) develop and pilot test an appropriate psycho educational intervention for minimizing negative outcomes after an abnormal TVS result. Results will enhance understanding of response to abnormal results in response to screening for OC and will also enhance understanding of response to abnormal screening results for other malignant and nonmalignant conditions.

描述（由申请人提供）：经阴道超声检查（TVS）可以促进卵巢癌（OC）的早期检测，但是，与所有癌症筛查测试一样，TVS会产生一定比例的“异常”发现。尽管绝大多数异常的电视结果都是良性的，但这种潜在的压力筛查经验对情感，认知和行为结果的影响尚未得到充分检查。拟议的研究基于我们当前的研究（R01 CA84036），即与常规电视筛查相关的心理和行为结果，通过明确关注异常电视的影响，结果。女性（n = 400）在常规筛查（异常筛查（AS）组中）接受异常电视，并在四八个星期后返回重复电视测试（年龄，事先筛查历史记录），女性（n = 400）在例行筛选（常规筛选（RS）组中，将获得正常电视的结果（n = 400）。所有妇女将在常规（RS组）或重复（作为组）电视筛查和后续评估1,4和基线后18个月之前完成基线评估。 AS组中的一些女性（n = 120）将在常规电视测试之前完成另外的“真实”基线评估，从而产生异常结果。在基线和情感（例如OC特定的困扰），认知（例如OC风险感知，TVS感知，TVS功效信念，福利发现）和行为（例如，OC特定的监测行为，情感上的CORMINE CORMINATIEN PERMINATIC CANCENTIP PINCEN CANCERS/CANCERIND PLOINS CANCERS/CANCERITIP）时。 OC筛选程序记录将对常规电视筛查的建议遵守。对压力事件的反应的几种当代理论模型（认知社会健康信息处理，监测过程，社会认知处理）指导研究变量的选择，并提供特定的测试假设。将解决三个具体目标：（1）表征异常电视对结果的性质，幅度，价和轨迹的影响； （2）确定与这些结果的大小和持久性相关的临床，人口，性格和心理社会变量； （3）开发和试点测试适当的心理教育干预措施，可在结果异常的情况下最大程度地减少负面结果。结果将增强对OC筛查的响应对异常结果的反应的理解，还将增强对其他恶性和非恶性条件异常筛查结果反应的理解。