SCREENING FOR OVARIAN CANCER--PSYCHOBEHAVIORAL OUTCOMES

卵巢癌筛查——心理行为结果

• 批准号: 6352111
• 负责人: MICHAEL A. ANDRYKOWSKI
• 金额: $ 0.82万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2004-02-29
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6352111
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; clinical research; cognition; coping; emotions; female; human subject; longitudinal human study; mass screening; neoplasm /cancer diagnosis; outcomes research; ovary neoplasms; psychological aspect of cancer; ultrasonography

Early detection of ovarian cancer (OC) is critical to management of the disease. While transvaginal sonography (TVS) is the preferred screening modality for OC, concerns have been raised regarding the cost/benefit ratio associated with TVS. While TVS has been shown to facilitate early detection of OC, TVS yields a high proportion of "abnormal" findings. These findings require additional follow-up in the form of repeat TVS testing or exploratory surgery. While the vast majority of these abnormal findings are ultimately determined to be "false positives," the impact of this potentiallly stressful experience upon a woman's cognition, affect, and behavior has not been adequately examined. This study will use a prospective, longitudinal design to examine psychological and behavioral outcomes associated with TVS screening for OC. Three groups of women will be studied: women undergoing an initial TVS test who receive a normal result (n=300), women undergoing an initial TVS test who receive an abnormal result (n=300), and a matched group of healthy women who have never undergone TVS testing (n=300). Assessments will be conducted prior to initial TVS test and at 2 week, and 4, 18, and 30 month followups. Guided by the conceptual framework provided by both the Cognitive-Social Health Information Processing (C-SHIP) and Monitoring Process Models, endpoints to be examined include cognition (e.g., risk perception, perceptions of TVS efficacy, intrusive and avoidant ideation), affect (e.g., depression, mood disturbance), and behavior (adherence to routine follow-up TVS testing). Research aims include: (1) characterization of women who undergo TVS screening; (2) identification of psychological and behavioral outcomes associated with TVS screening; and (3) identification of clinical, demographic, and psychological variables associated with post-TVS psychological and behavioral outcomes. Regarding the latter aim, hypotheses regarding the relationship between informational coping style (e.g., high monitoring) and post-TVS psychological and behavioral outcomes will be tested. Results will enable development of interventions to enhance psychological and behavioral outcomes after TVS screening for OC.

卵巢癌（OC）的早期发现对疾病的管理至关重要。虽然经阴道超声检查（TVS）是OC的首选筛选方式，但人们对与电视相关的成本/收益率提出了担忧。 尽管已显示电视有助于早期发现OC，但电视会产生很大比例的“异常”发现。这些发现需要进行重复测试或探索性手术的形式的额外随访。 尽管这些异常发现中的绝大多数最终被确定为“误报”，但这种潜在的压力经历对妇女的认知，情感和行为的影响尚未得到充分检查。这项研究将使用前瞻性的纵向设计来检查与OC的电视筛查相关的心理和行为结果。 将研究三组​​女性：接受初始电视测试的妇女接受正常结果（n = 300），接受初始电视测试的妇女接受异常结果（n = 300），以及一组从未经过电视测试的健康女性（n = 300）。 评估将在初始电视测试和2周以及4、18和30个月的随访之前进行评估。 Guided by the conceptual framework provided by both the Cognitive-Social Health Information Processing (C-SHIP) and Monitoring Process Models, endpoints to be examined include cognition (e.g., risk perception, perceptions of TVS efficacy, intrusive and avoidant ideation), affect (e.g., depression, mood disturbance), and behavior (adherence to routine follow-up TVS testing). 研究目的包括：（1）进行电视筛查的女性的表征； （2）鉴定与电视筛查相关的心理和行为结果； （3）鉴定与TVS后心理和行为结果相关的临床，人口统计和心理变量。 关于后一个目标，将测试有关信息应对方式（例如，高监测）与TVS心理和行为结果之间关系的假设。 结果将使开发干预措施，以增强电视筛查OC后的心理和行为结果。