DRUG USE LIABILITY: INVESTIGATING COMPETING MODELS

药物使用责任：研究竞争模型

• 批准号: 6693429
• 负责人: TY A RIDENOUR
• 金额: $ 10.71万
• 依托单位: PENNSYLVANIA STATE UNIVERSITY, THE
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-08-16 至 2005-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6693429
• 关键词: behavior prediction; behavioral /social science research tag; clinical research; diagnosis design /evaluation; disease /disorder proneness /risk; drug abuse; drug abuse prevention; environmental exposure; human subject; interview; middle childhood (6-11); psychometrics; socioenvironment; substance abuse related behavior

This Mentored Research Scientist Development Award (K01) application requests support for five years to investigate how risk and protective factors combine to put pre-teens at some overall drug use liability level. Many risk and protective factors pertaining to drug use, and dependence have been identified, however, few studies have investigated the association between risk factors among children prior to their first ingestion of drugs and later drug use, abuse, and dependence. Even fewer studies have examined how the various risk and protective factors combine to put individuals at some overall risk for (liability to) substance use. Under the mentorship of experts in psychopathological assessment, this study would a) develop a computer-administered instrument titled the Assessment of Liability and EXposure to Substance Use (ALEXSU) and b) prospectively test competing models of drug misuse liability. The ALEXSU would a) not require minimum reading or writing levels, b) be computerized because computer- based assessments of drug abuse generate increased reporting of substance use (Reich, et al., 1995; Turner, et al., 1998), and c) be enhanced with developmentally appropriate and culturally neutral graphics. The research plan proposes to a) develop the ALEXSU from existing measures designed for older individuals, b) investigate the ALEXSU's one-week test-retest reliability among 9 to 12 year old children, c) investigate how well ALEXSU scores predict stages of use and drug-related psychiatric symptoms for a variety of legal and illicit substances two years later and d) test three competing models of drug use liability against each other against a model that combines them, and against a simple summation score of the number of risk factors that participants report. Samples represent high- and low-risk populations. Small-scale validity studies of the ALEXSU will be conducted. Competing liability models will be compared in terms of how accurately they predict three drug use variables (having tried a drug, stage of drug use, and having an abuse or dependence symptom) at the two-year follow-up. The execution of the proposed research plan, formal coursework, and mentoring from the Sponsor and Co-Preceptors will facilitate the Applicant's a) transition in scientific focus to substance use, abuse, and dependence; b) acquisition of advanced analytical skills regarding substance use assessment and d) a platform from which to pursue a career of independently funded substance use research.

这项指导的研究科学家发展奖（K01）的申请要求为五年的支持提供支持，以调查风险和保护因素如何结合到一些总体药物使用责任水平。 与药物使用有关的许多风险和保护因素以及依赖性已被确定，但是很少有研究研究儿童在初次摄入药物和后来的药物使用，滥用和依赖性之前的危险因素之间的关联。 甚至更少的研究都研究了各种风险和保护因素如何结合在一起，使个人有某种总体风险（责任）使用物质。 在精神病学评估专家的指导下，本研究将a）开发一种标题为“评估责任和暴露于物质使用的评估（Alexsu）的工具（Alexsu），b）前瞻性测试竞争性药物滥用责任的模型。 Alexsu将不需要最低读数或写作水平，b）计算机化，因为对药物滥用的基于计算机的评估会增加对药物使用的报告（Reich等，1995; Turner等，1998），并且C）可以通过发育适当的和文化的中性图形来增强。 The research plan proposes to a) develop the ALEXSU from existing measures designed for older individuals, b) investigate the ALEXSU's one-week test-retest reliability among 9 to 12 year old children, c) investigate how well ALEXSU scores predict stages of use and drug-related psychiatric symptoms for a variety of legal and illicit substances two years later and d) test three competing models of drug use liability against each other against a model that combines them, and against a simple参与者报告的风险因素数量的求和得分。 样品代表高风险和低风险人群。将对Alexsu进行小规模的有效性研究。在两年的随访中，将根据他们预测三个药物使用变量（尝试过药物，药物使用阶段以及患有滥用或依赖症状）的准确程度来比较竞争责任模型。 拟议的研究计划，正式课程以及赞助商和共同感染者的指导将促进申请人的a）科学重点过渡到物质使用，滥用和依赖； b）获取有关物质使用评估和d）从事独立资助的物质使用研究职业的平台的高级分析技能。