Inhalant Abuse and Dependence
吸入滥用和依赖性
基本信息
- 批准号:6665468
- 负责人:
- 金额:$ 25.72万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2002
- 资助国家:美国
- 起止时间:2002-09-22 至 2005-06-30
- 项目状态:已结题
- 来源:
- 关键词:adolescence (12-20) aerosols behavioral /social science research tag clinical research disease /disorder onset drug addiction drug withdrawal gas human subject inhalation drug abuse inhalation drug administration interview nitrites psychological tests psychometrics solvents substance abuse epidemiology substance abuse related behavior young adult human (21-34)
项目摘要
DESCRIPTION (provided by applicant): Ongoing surveillance studies consistent suggest that inhalants are the fourth most prevalently used psychoactive substance. Inhalants are unique among drugs of abuse because they are legal for all ages, easily accessible, and inexpensive. Moreover, the immediate medical consequences of inhalant use, including respiratory problems, damage to the liver, heart, or brain, and even death, can be much more severe than the more prevalently used substances: tobacco, alcohol, and marijuana. Surveillance data indicate that inhalants generally are first used at a young age (consistently nearly 20% of 8th graders surveyed in the Monitoring the Future study report having used inhalants), suggesting that inhalant use may play a developmental role in use of other substances such as cocaine or opiates. Relative to other substances, however, very little is known about inhalant use and even less is known about inhalant abuse and dependence. Such data are critical to a relevant public health response and prevention efforts directed at inhalant misuse. For illustration, although a withdrawal syndrome for inhalants is absent from the DSM-IV, preliminary data collected in our laboratory suggest that inhalant withdrawal is experienced by some inhalant users. We propose to develop Substance Abuse Module (SAM) questions specifically for the different types of inhalants (solvents, aerosols, gases, and nitrites) and to quantitatively estimate the psychometrics of a general inhalants category of abuse and dependence diagnoses, preliminarily study separate diagnoses for the different types of inhalants, investigate the occurrence of inhalant use-related abuse and dependence among users of inhalants, qualitatively explore the experiences of inhalant users relevant to their inhalant use (e.g., how did they learn about inhalants, did their inhalant use lead to trying other drugs), and to explore qualitatively parents' and health care professionals' knowledge of inhalants, consequences of use, and efforts to warn children of this danger. We also will study the comorbidity and age-of-onset of other substance use-related disorders among inhalant users. We proposed to address these issues by reanalyzing the WHO/NIDA/NIAAA Reliability and Validity of Substance Use Disorders data, conducting focus groups, and conducting a test-retest-validity study of abuse and dependence disorders in older adolescent and young adult inhalant users with questions regarding specific types of inhalants.
描述(由申请人提供):正在进行的监测研究一致表明,吸入剂是第四大最常用的精神活性物质。吸入剂在滥用药物中是独一无二的,因为它们对所有年龄段都是合法的,易于获取且价格低廉。此外,吸入使用的直接医疗后果,包括呼吸问题、肝脏、心脏或大脑损伤,甚至死亡,可能比更普遍使用的物质:烟草、酒精和大麻严重得多。监测数据表明,吸入剂通常在年轻时首次使用(《监测未来》研究报告中调查的八年级学生中,近 20% 的学生始终使用过吸入剂),这表明吸入剂的使用可能在使用其他物质(如可卡因或阿片类药物。然而,相对于其他物质,人们对吸入剂的使用知之甚少,对吸入剂的滥用和依赖性更是知之甚少。此类数据对于针对吸入剂滥用的相关公共卫生应对和预防工作至关重要。例如,虽然 DSM-IV 中没有出现吸入剂戒断综合征,但我们实验室收集的初步数据表明,一些吸入剂使用者会经历吸入剂戒断症状。我们建议专门针对不同类型的吸入剂(溶剂、气溶胶、气体和亚硝酸盐)开发物质滥用模块(SAM)问题,并定量估计一般吸入剂类别的滥用和依赖诊断的心理测量,初步研究单独的诊断不同类型的吸入剂,调查吸入剂使用者中与吸入剂使用相关的滥用和依赖的发生情况,定性探索吸入剂使用者与其吸入剂使用相关的经历(例如,他们如何了解吸入剂,他们的吸入剂使用是否导致尝试其他药物),并定性探索父母和医疗保健专业人员对吸入剂的了解、使用后果以及警告儿童这种危险的努力。我们还将研究吸入剂使用者中其他与物质使用相关的疾病的合并症和发病年龄。我们建议通过重新分析 WHO/NIDA/NIAAA 药物使用障碍数据的可靠性和有效性、开展焦点小组以及对老年青少年和年轻成人吸入性使用者的滥用和依赖障碍进行测试-再测试-有效性研究来解决这些问题。有关特定类型吸入剂的问题。
项目成果
期刊论文数量(0)
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{{ truncateString('TY A RIDENOUR', 18)}}的其他基金
DRUG USE LIABILITY: INVESTIGATING COMPETING MODELS
药物使用责任:研究竞争模型
- 批准号:
6617787 - 财政年份:2000
- 资助金额:
$ 25.72万 - 项目类别:
DRUG USE LIABILITY: INVESTIGATING COMPETING MODELS
药物使用责任:研究竞争模型
- 批准号:
6130467 - 财政年份:2000
- 资助金额:
$ 25.72万 - 项目类别:
DRUG USE LIABILITY: INVESTIGATING COMPETING MODELS
药物使用责任:研究竞争模型
- 批准号:
6780959 - 财政年份:2000
- 资助金额:
$ 25.72万 - 项目类别:
DRUG USE LIABILITY: INVESTIGATING COMPETING MODELS
药物使用责任:研究竞争模型
- 批准号:
6378313 - 财政年份:2000
- 资助金额:
$ 25.72万 - 项目类别:
DRUG USE LIABILITY: INVESTIGATING COMPETING MODELS
药物使用责任:研究竞争模型
- 批准号:
6693429 - 财政年份:2000
- 资助金额:
$ 25.72万 - 项目类别:
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