CORE--DATA MANAGEMENT AND BIOSTATISTICS

核心——数据管理和生物统计学

• 批准号: 6481087
• 负责人: PATRICK JOHN FOX
• 金额: $ 8.96万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2007-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6481087
• 关键词: Alzheimer's disease; aging; biomedical facility; data management; dementia; human middle age (35-64); human old age (65+); human subject; information systems; neural degeneration; progressive supranuclear palsy; statistics /biometry

DESCRIPTION (provided by applicant): The purpose of the Data Management and Biostatistical Core is to provide database and statistical support for the entire PPG. The specific aims are to manage the multi-disciplinary database incorporating data from the Clinical and Administrative Core, the Pathology Core, and the four individual Projects; and provide statistical consultation to all PPG investigators. The UCSF Institute for Health and Aging (IHA), in partnership with the UCSF Department of Epidemiology and Biostatistics, will serve as the Data Management and Biostatistics Core for the proposed project. In this capacity, the data management and analysis team will design, develop and implement a data management system that will securely maintain all data that are collected from the Cores and Projects. Development of standardized data collection and management procedure will be accomplished. All instrument protocols will be maintained in a Manual of Procedures. In addition to instrument protocols, the Manual will include protocols for: 1) sample recruitment; 2) data collection; 3) submission of data to the centralized database, and 4) administrative issues. This core will create and manage a single dataset that integrates all the error-checked, standardized data from each site and makes it available to the research teams via an "intranet" site. Data security will be addressed at multiple levels. The Biostatistics Core will address the statistical issues that arise in all the Projects. Specific statistical topics (tasks) will vary by Project, but concerns related to data reduction, classification and reliability studies are common to many of the Projects and will be managed through this Core.

描述（由申请人提供）：数据管理的目的和 生物统计核心是为生物统计提供数据库和统计支持 整个PPG。具体目标是管理多学科数据库 整合来自临床和行政核心、病理学的数据 核心，以及四个单独的项目；并提供统计咨询 致所有 PPG 调查员。加州大学旧金山分校健康与老龄化研究所 (IHA) 与加州大学旧金山分校流行病学和生物统计学系合作，将 作为拟议项目的数据管理和生物统计核心。 以此身份，数据管理和分析团队将设计、开发 并实施一个数据管理系统来安全地维护所有数据 从核心和项目中收集的。标准化发展 将完成数据收集和管理程序。所有仪器 协议将保​​存在程序手册中。此外 仪器协议，手册将包括以下协议：1) 样品 招聘; 2）数据收集； 3）向集中提交数据 数据库，以及 4) 管理问题。该核心将创建和管理 单个数据集集成了所有经过错误检查的标准化数据 每个站点并通过“内部网”站点向研究团队提供。 数据安全将在多个层面得到解决。生物统计学核心 将解决所有项目中出现的统计问题。具体的 统计主题（任务）将因项目而异，但与数据相关的关注点 减少、分类和可靠性研究对于许多 项目将通过该核心进行管理。