Core--Clinical

核心--临床

• 批准号: 6578726
• 负责人: CLAUDIA H. KAWAS
• 金额: $ 15.83万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6578726
• 关键词: Alzheimer's disease; aging; biomedical facility; brain disorder diagnosis; clinical research; cognition; dementia; human middle age (35-64); human old age (65+); human subject; neuroanatomy; patient /disease registry; statistical service /center

DESCRIPTION: (Adapted from the application) The principal functions of Core B, the Clinical Core of the ADRC, are: to recruit, characterize, and follow subjects as part of their clinical and neurobiological investigations of normal aging and AD; and to provide a resource for all investigators at JHMI involved in the investigation of aging and AD, including clinical trials, genetic studies, imaging studies, and neuropathological neurochemical analyses of brain. Because cognitive performance in the elderly varies widely, ranging from normal cognition to severe dementia, the staff of Core B has assembled several cohorts (~700 subjects) to examine the full spectrum of cognitive states associated with old age. The centerpiece of Core B, however, is investigations of nondemented elderly subjects and patients in the early stages of AD. Thus, Core B has enrolled 500 normal subjects of the BLSA, as well as ~100 subjects with early AD and 75 controls (Cohort 2), in addition to the remaining 25 severely demented members of the original ADRC cohort (Cohort 1). Significantly, more than one-third of all AD patients recruited in the last funding period were African-Americans, a group which has been under-represented in studies of AD. Cohorts 1 and 2 are used for our investigations of AD, whereas the BLSA cohort serves as the focus for our clinical, and neuropathological studies of normal aging and early stages of dementia. The Biostatistics & Data Center, staffed by professionals with expertise in statistical methods for longitudinal studies and analytical approaches to data management, functions to collect, maintain, and analyze the demographic and clinical information on all subjects and to facilitate data sharing efforts, particularly with the ADC Data Coordinating Center. The staff of Core B, with expertise in neurology, psychiatry, biostatistics, and nursing, interacts closely with investigators in Core C and supports research in Project 4. Complementing the investigations of experimental models (Projects 1-3) in our ADRC, Core B is a central clinical resource for all investigations of human subjects in the ADRC and for other investigators at JHMI.

描述：（从应用程序改编） ADRC的临床核心核心B的主要功能是： 作为其临床的一部分，招募，特征和遵循受试者 正常衰老和AD的神经生物学研究；并提供一个 JHMI的所有研究人员的资源参与了衰老调查 和AD，包括临床试验，遗传研究，成像研究和 大脑的神经病理神经化学分析。因为认知 老年人的表现差异很大，从正常认知到 严重的痴呆症，核心B的工作人员组装了几个队列（〜700 受试者）检查与旧的认知状态的完整范围 年龄。然而，核心B的核心是对非核心的调查 在AD的早期阶段，老年人和患者。因此，核心B具有 招募了500名BLSA的正常受试者，以及〜100个受试者 AD和75个对照（队列2），除其余25个严重 原始ADRC队列的痴呆成员（队列1）。重要的是，更多 在最后一个资金期间招募的所有广告患者中，超过三分之一 非裔美国人，在AD研究中的代表性不足。 队列1和2用于我们对AD的研究，而BLSA队列 是我们临床的重点，正常的神经病理学研究 痴呆症的衰老和早期阶段。生物统计学和数据中心人员 由具有纵向统计方法专业知识的专业知识的专业人士 数据管理的研究和分析方法，收集功能， 维护和分析有关所有受试者的人口统计和临床信息 并促进数据共享工作，特别是使用ADC数据 协调中心。 Core B的工作人员，具有神经病学专业知识， 精神病学，生物统计学和护理，与研究人员紧密互动 在核心C中支持项目4中的研究。补充调查 在我们的ADRC中的实验模型（项目1-3）中，核心B是中心 对ADRC和ADRC中人类受试者的所有调查的临床资源 JHMI的其他调查人员。