Core--Clinical

核心--临床

• 批准号: 6578726
• 负责人: CLAUDIA H. KAWAS
• 金额: $ 15.83万
• 依托单位: JOHNS HOPKINS UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-04-01 至 2003-03-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6578726
• 关键词: Alzheimer's disease; aging; biomedical facility; brain disorder diagnosis; clinical research; cognition; dementia; human middle age (35-64); human old age (65+); human subject; neuroanatomy; patient /disease registry; statistical service /center

DESCRIPTION: (Adapted from the application) The principal functions of Core B, the Clinical Core of the ADRC, are: to recruit, characterize, and follow subjects as part of their clinical and neurobiological investigations of normal aging and AD; and to provide a resource for all investigators at JHMI involved in the investigation of aging and AD, including clinical trials, genetic studies, imaging studies, and neuropathological neurochemical analyses of brain. Because cognitive performance in the elderly varies widely, ranging from normal cognition to severe dementia, the staff of Core B has assembled several cohorts (~700 subjects) to examine the full spectrum of cognitive states associated with old age. The centerpiece of Core B, however, is investigations of nondemented elderly subjects and patients in the early stages of AD. Thus, Core B has enrolled 500 normal subjects of the BLSA, as well as ~100 subjects with early AD and 75 controls (Cohort 2), in addition to the remaining 25 severely demented members of the original ADRC cohort (Cohort 1). Significantly, more than one-third of all AD patients recruited in the last funding period were African-Americans, a group which has been under-represented in studies of AD. Cohorts 1 and 2 are used for our investigations of AD, whereas the BLSA cohort serves as the focus for our clinical, and neuropathological studies of normal aging and early stages of dementia. The Biostatistics & Data Center, staffed by professionals with expertise in statistical methods for longitudinal studies and analytical approaches to data management, functions to collect, maintain, and analyze the demographic and clinical information on all subjects and to facilitate data sharing efforts, particularly with the ADC Data Coordinating Center. The staff of Core B, with expertise in neurology, psychiatry, biostatistics, and nursing, interacts closely with investigators in Core C and supports research in Project 4. Complementing the investigations of experimental models (Projects 1-3) in our ADRC, Core B is a central clinical resource for all investigations of human subjects in the ADRC and for other investigators at JHMI.

描述：（改编自应用程序） 核心 B（ADRC 的临床核心）的主要职能是： 招募、表征和跟踪受试者作为其临床和治疗的一部分 正常衰老和 AD 的神经生物学研究；并提供一个 为 JHMI 参与衰老研究的所有研究人员提供的资源 和 AD，包括临床试验、基因研究、影像学研究和 大脑的神经病理学神经化学分析。因为认知 老年人的表现差异很大，从正常认知到 由于患有严重痴呆症，Core B 的工作人员已经召集了几个小组（约 700 受试者）检查与老年相关的全方位认知状态 年龄。然而，核心 B 的核心是对非痴呆症患者的调查 老年受试者和 AD 早期患者。因此，核心 B 有 BLSA 招募了 500 名正常受试者，以及约 100 名早期受试者 AD 和 75 名对照者（队列 2），以及其余 25 名严重 最初 ADRC 队列（队列 1）的精神错乱成员。值得注意的是，更多 上一个资助期招募的所有 AD 患者中，有超过三分之一是 非裔美国人是 AD 研究中代表性不足的群体。 队列 1 和队列 2 用于我们的 AD 调查，而 BLSA 队列 是我们对正常人的临床和神经病理学研究的重点 衰老和痴呆症的早期阶段。生物统计和数据中心，人员配备 由具有统计方法专业知识的专业人员进行纵向 数据管理的研究和分析方法、收集功能、 维护和分析所有受试者的人口统计和临床信息 并促进数据共享工作，特别是与 ADC 数据共享 协调中心。 Core B 的工作人员拥有神经病学方面的专业知识， 精神病学、生物统计学和护理学，与研究人员密切互动 核心 C 并支持项目 4 中的研究。补充调查 在我们的 ADRC 实验模型（项目 1-3）中，核心 B 是一个核心 ADRC 中所有人类受试者研究的临床资源 JHMI 的其他研究人员。