Estrogenic Component of the Vascular Etiology of Alzheimer's Disease

阿尔茨海默病血管病因学中的雌激素成分

• 批准号: 10713773
• 负责人: S MICHAL JAZWINSKI
• 金额: $ 38.23万
• 依托单位: TULANE UNIVERSITY OF LOUISIANA
• 依托单位国家: 美国
• 财政年份: 2022
• 资助国家: 美国
• 起止时间: 2022-06-01 至 2027-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10713773
• 关键词: Address; Adopted; Aging; Alzheimer' s Disease; Area; Bioinformatics; Biological Aging; Biological Process; Biomedical Research; Cell Proliferation; Cementation; Centers of Research Excellence; Chronic Disease; Clinical; Collaborations; Communities; Core Facility; Dedications; Degenerative Disorder; Development; Disease; Educational workshop; Elements; Environment; Etiology; Extramural Activities; Faculty; Feedback; Foundations; Funding; Genome Stability; Genomics; Goals; Grant; Growth; Health; Homeostasis; Immunity; Inflammaging; Inflammation; Infrastructure; Institution; Interdisciplinary Study; Intervention; Knowledge; Life; Life Expectancy; Longevity; Maintenance; Measures; Mentors; Metabolic; Musculoskeletal; Natural regeneration; Neurocognitive; Pathogenesis; Phase; Physical Function; Pilot Projects; Positioning Attribute; Preventive; Process; Program Description; Program Development; Public Health; Quality of life; Regenerative Medicine; Regenerative research; Regulation; Research; Research Infrastructure; Research Personnel; Retirement; Risk Factors; Services; Talents; Therapeutic Intervention; Time; Training; Training Programs; Twin Multiple Birth; Universities; Update; aging population; aspirate; baby boomer; base; career development; cognitive function; cohort; design; estrogenic; expectation; improved; interest; medical schools; molecular imaging; multidisciplinary; neuroinflammation; programs; psychosocial; soft tissue; stem cell function; success; sustainable resource; therapeutic development; vascular factor; wound healing; Address; Adopted; Aging; Alzheimer' s Disease; Area; Bioinformatics; Biological Aging; Biological Process; Biomedical Research; Cell Proliferation; Cementation; Centers of Research Excellence; Chronic Disease; Clinical; Collaborations; Communities; Core Facility; Dedications; Degenerative Disorder; Development; Disease; Educational workshop; Elements; Environment; Etiology; Extramural Activities; Faculty; Feedback; Foundations; Funding; Genome Stability; Genomics; Goals; Grant; Growth; Health; Homeostasis; Immunity; Inflammaging; Inflammation; Infrastructure; Institution; Interdisciplinary Study; Intervention; Knowledge; Life; Life Expectancy; Longevity; Maintenance; Measures; Mentors; Metabolic; Musculoskeletal; Natural regeneration; Neurocognitive; Pathogenesis; Phase; Physical Function; Pilot Projects; Positioning Attribute; Preventive; Process; Program Description; Program Development; Public Health; Quality of life; Regenerative Medicine; Regenerative research; Regulation; Research; Research Infrastructure; Research Personnel; Retirement; Risk Factors; Services; Talents; Therapeutic Intervention; Time; Training; Training Programs; Twin Multiple Birth; Universities; Update; aging population; aspirate; baby boomer; base; career development; cognitive function; cohort; design; estrogenic; expectation; improved; interest; medical schools; molecular imaging; multidisciplinary; neuroinflammation; programs; psychosocial; soft tissue; stem cell function; success; sustainable resource; therapeutic development; vascular factor; wound healing

Aging is a biological process that is the major risk factor for chronic disease and degeneration during the lifespan. However, it is beginning to be appreciated that disease and degeneration impinge on the aging process, in something akin to a feedback loop, suggesting that a better knowledge of one contributes to an understanding of the other. This necessitates that development of therapeutic interventions must address the degenerative disorders of aging, while the search for broad interventions that target the biological aging process itself continues. The agenda just described calls for the creation and nurturing of an environment in which multidisciplinary research of sufficient breadth is focused on key elements of aging and regeneration. At the same time, it is necessary to populate this translational space with talented and successful investigators. Our Phase I and II COBRE launched and further propelled us in this direction by allowing us to seed several key research topics with ambitious junior investigators, who in just nine years have advanced to independently funded status with remarkable success. Our task is not yet done, however, if we are to maintain momentum and a critical mass of investigators dedicated to aging and regenerative medicine. COBRE Phase III will allow us to continue to grow our cadre of dedicated investigators through our pilot projects and by enriching the research environment through our mentoring and training programs, as well as topical seminars. These efforts will be aided by the maintenance of a state-of-the-art Genomics, Bioinformatics, and Molecular Imaging Core that has a sustaining revenue base. Our emphasis is on multiplying the opportunities for interactions that will generate collaborative projects that are synergistic and competitive for multicomponent project grant funding. Our goals are to: (1) Continue to expand the number of aging and regeneration research-oriented, funded investigators within our scientific community through our pilot projects, with emphasis on collaborative research, and to provide a mentoring program for these researchers and others that supports successful career development. (2) Maintain our state-of-the-art infrastructure to provide sustainable resources that continuously enhance the competitiveness of our faculty for national funding, by expanding and updating the services performed by our Genomics, Bioinformatics, and Molecular Imaging Core. (3) Cement the position of the Tulane Center for Aging at the forefront of aging and regenerative medicine by growth of our thematic, multidisciplinary research foci to facilitate successful extramurally funded collaborations that will support and sustain the center. This effort will be supported by our research workshops, training and career development programs, and seminars.

衰老是一个生物学过程，是慢性疾病和变性的主要危险因素 寿命。但是，人们开始理解疾病和变性会影响衰老 过程，类似于反馈循环的事物，表明对一个人的更好了解有助于 对对方的理解。这必须使治疗干预措施的发展必须解决 衰老的退化性疾病，而寻找针对生物衰老的广泛干预措施 过程本身继续。议程刚刚描述了在环境中创造和培养环境的呼吁 对足够广度的多学科研究集中在衰老和再生的关键要素上。在 同时，有必要与才华横溢且成功的研究人员一起填充这一转化空间。 我们的第一阶段和第二阶段的鞋垫推出并进一步推动了我们，通过允许我们播种几个 雄心勃勃的初级调查员的主要研究主题 获得了巨大成功的资助。但是，如果我们要保持动力，我们的任务尚未完成 以及致力于衰老和再生医学的重要研究人员。山科阶段III将允许 我们继续通过飞行员项目来发展我们的专门研究人员的干部，并通过丰富 通过我们的指导和培训计划以及主题研讨会进行研究。这些努力 维持最先进的基因组学，生物信息学和分子成像核心将有助于 这有一个维持收入基础。我们的重点是增加互动的机会 生成协同项目的协作项目，对多组件项目赠款资金具有竞争力。 我们的目标是：（1）继续扩大面向研究的老龄化和重生的数量 我们科学界的调查人员通过我们的试点项目，重点是协作 研究，并为这些研究人员和其他支持成功的研究人员提供指导计划 职业发展。 （2）维护我们最先进的基础设施，以提供可持续资源 通过扩大和更新 我们的基因组学，生物信息学和分子成像核心执行的服务。 （3）水泥的位置 杜兰的衰老中心是我们主题的增长，在衰老和再生医学的最前沿 多学科研究重点，旨在促进成功的外部资助合作，以支持和 维持中心。这项工作将得到我们的研究研讨会，培训和职业发展的支持 节目和研讨会。