Core B-Clinical Core

核心 B-临床核心

• 批准号: 9922101
• 负责人: CLAUDIA H. KAWAS
• 金额: $ 61.75万
• 依托单位: UNIVERSITY OF CALIFORNIA-IRVINE
• 依托单位国家: 美国
• 财政年份: 2020
• 资助国家: 美国
• 起止时间: 2020-06-15 至 2025-02-28
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/9922101
• 关键词: Alzheimer associated neurodegeneration; Alzheimer' s Disease; Amyloid; Ancillary Study; Asian Americans; Asians; Autopsy; Biochemical; Biological Markers; Blood; Blood Vessels; Brain; California; Cardiovascular system; Cell Line; Cerebrospinal Fluid; Cessation of life; Chinese American; Clinical; Clinical Data; Clinical Research; Clinical Trials; Clinical assessments; Cognitive; Collaborations; Collection; Consent; Data; Data Set; Dementia; Deposition; Diagnostic; Disease; Ecosystem; Education; Enrollment; Ethnic Origin; Female; Fibroblasts; Funding; Generations; Genetic; Hispanics; Home environment; Image; Impaired cognition; Individual; Investigation; Link; Longevity; Longitudinal cohort; Magnetic Resonance Imaging; Methodology; Minority; Mission; Molecular; Neurocognitive; Neurologic; Participant; Peripheral Blood Mononuclear Cell; Population; Positron-Emission Tomography; Procedures; Punch Biopsy; Questionnaires; Race; Randomized; Registries; Research; Research Personnel; Research Project Grants; Research Support; Resolution; Resources; Risk; Role; Sampling; Skin; Spinal Puncture; Symptoms; System; Telephone; Telephone Interviews; Tissue Donations; Training; Training and Education; Translational Research; Universities; clinical trial participant; cognitive testing; cohort; data management; demented; disorder risk; education research; follow-up; genetic analysis; improved; inclusion criteria; induced pluripotent stem cell; innovation; mild cognitive impairment; neuroimaging marker; next generation; novel; outreach; pre-clinical; programs; recruit; retention rate; stem cells; tau Proteins; tissue biomarkers

Core B: Clinical Core Project Summary/Abstract The UCI ADRC Clinical Core enrolls, characterizes and follows a cohort of individuals who are cognitively unimpaired, cognitively impaired, or demented, each of whom complete the Uniform Data Set (UDS) consisting of physical and neurological exams and a battery of neurocognitive assessments. In addition to this UDS, participants and their study partners complete questionnaires and assessments unique to our ADRC, and voluntarily contribute a variety of tissue and biomarker assessments, including genetic analyses, volumetric imaging, cerebrospinal fluid analyses, and donation of fibroblasts for the generation of induced pluripotent stem cells (iPSC). Overall, 292 of our current 330 active participants have donated fibroblasts or peripheral blood mononuclear cells (PBMCs), which have been used to generate 192 iPSC lines by our iPSC Core. Most participants agree to brain donation at autopsy and we have a high rate of successful completion of autopsy confirmation at death. Our UDS cohort currently includes 330 active participants. Among this cohort, 60% are female and one third are non-White race or Hispanic ethnicity. Nineteen percent are demented, 18% meet criteria for Mild Cognitive Impairment (MCI), and a majority (60%) do not meet diagnostic criteria for MCI or dementia. Our overall retention rates are very high and above the median for the ADRC system. Most UDS participants have been enrolled in externally funded ancillary studies, ranging from telephone interview studies to neuroimaging biomarker research. To support the increasing needs of ADRC investigators, including novel studies of molecular and vascular biomarkers, we will grow this UDS cohort to a steady state n=400, with an emphasis on enrolling individuals who enable novel studies in support of the UCI ADRC theme “to identify, quantify, and validate factors that influence the risk of AD across the lifespan.”!

核心B：临床核心 项目摘要/摘要 UCI ADRC临床核心注册，具有特征性并遵循认知上的人群 无启用，认知受损或痴呆，每个人都完成了统一数据集（UDS） 身体和神经系统检查以及一系列神经认知评估。除了这个UDS， 参与者及其学习伙伴填写了我们ADRC独有的问卷和评估，以及 自愿贡献各种组织和生物标志物评估，包括遗传分析，体积 成像，脑脊液分析和成纤维细胞的捐赠，以生成诱导的多能茎 细胞（IPSC）。总体而言，我们目前的330名活跃参与者中有292名捐赠了成纤维细胞或外周血 单核细胞（PBMC）已用于通过我们的IPSC核心生成192个IPSC线。最多 参与者同意尸检大脑捐赠，我们成功完成尸检率很高 死亡时的确认。我们的UDS队列目前包括330名活跃参与者。在这个队列中，有60％是 女性和三分之一是非白人种族或西班牙裔种族。十九％的痴呆症，18％的人见面 轻度认知障碍的标准（MCI），多数（60％）不符合MCI的诊断标准或 失智。我们的总体保留率很高，高于ADRC系统的中位数。大多数UDS 参与者已入学外部资助的辅助研究，从电话访谈研究等 神经影像学生物标志物研究。支持ADRC调查人员不断增长的需求，包括新颖 分子和血管生物标志物的研究，我们将将此UDS队列增长到稳态n = 400，并与 强调招生能够支持UCI ADRC主题的个人的个人，以确定，确定， 量化并验证影响整个寿命中AD风险的因素。”！