DATA MANAGEMENT AND BIOSTATISTICS

数据管理和生物统计学

• 批准号: 7407533
• 负责人: PATRICK JOHN FOX
• 金额: $ 17.98万
• 依托单位: UNIVERSITY OF CALIFORNIA, SAN FRANCISCO
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7407533
• 关键词: Address; Age; Aging; Alzheimer' s Disease; Biometry; Biostatistics Core; California; Clinic; Clinical Research; Confidentiality; Consult; Consultations; Data; Data Analyses; Data Quality; Data Set; Databases; Dementia; Ensure; Foundations; Genetic; Goals; Health; Institutes; Memory; Molecular Biology; Patients; Process; Purpose; Range; Research; Research Design; Research Personnel; Research Project Grants; Resolution; San Francisco; System; Universities; cohort; data management; interest; neurobehavioral; neuroimaging; neuropathology; programs; quality assurance; research study; statistical service

The Data Management and Biostatistics core will provide high quality data management services and statistical consulting to the University of California at San Francisco (UCSF) Alzheimer's Disease Research Center (ADRC) research projects and cores. The core will build upon the ongoing partnership between UCSF's Institute of Health and Aging (IHA) and the UCSF Memory and Aging Center (MAC). The partnership between the Memory and Aging Center (MAC) and the Institute of Health and Aging (IHA) combines over seventeen years of IHA data management expertise with a comprehensive MAC data management program, providing a strong foundation to support the goals of the UCSF ADRC to capture a broad range of neurobehavioral, genetic, neuroimaging, neuropathology and molecular biology data on a large cohort of AD and non-AD dementia patients. The strength of the UCSF ADRC data management system will be the ability to integrate and share information between all cores, projects and clinic/lab(s), greatly facilitating the progress of the research studies. In addition, the data management processes that will be implemented will ensure a timely and accurate dataset submission to the National Alzheimer's Coordinating Center (NACC), as well as the sharing of data among other external researchers. Biostatistical consultation on the design of studies and the analysis of data will be offered across all UCSF ADRC cores and projects. This consultation will produce effective, valid analyses of project data that address the research questions of interest. The specific aims of the core include (1) maintaining a centralized UCSF ADRC clinical and research database, ensuring the integrity, availability, and confidentiality of all UCSF ADRC core and project data; (2) developing and maintaining a comprehensive data quality assurance program to ensure the identification and resolution of data errors across the USCF ADRC projects and cores; (3) develop and maintaining appropriate data management processes to ensure the timely and accurate submission of all datasets requested by the NACC; and (4) providing statistical consultation on research design and data analysis to all UCSF ADRC cores and projects.

数据管理和生物统计核心将为加州大学旧金山分校（UCSF）阿尔茨海默病研究中心（ADRC）的研究项目和核心提供高质量的数据管理服务和统计咨询。该核心将建立在加州大学旧金山分校健康与老龄化研究所 (IHA) 和加州大学旧金山分校记忆与老龄化中心 (MAC) 之间持续的合作伙伴关系的基础上。记忆与衰老中心 (MAC) 与健康与衰老研究所 (IHA) 之间的合作伙伴关系将 IHA 超过 17 年的数据管理专业知识与全面的 MAC 数据管理计划相结合，为支持 UCSF ADRC 的目标提供了坚实的基础捕获大量 AD 和非 AD 痴呆患者的广泛神经行为、遗传、神经影像、神经病理学和分子生物学数据。 UCSF ADRC 数据管理系统的优势在于能够在所有核心、项目和诊所/实验室之间集成和共享信息，极大地促进研究的进展。此外，将实施的数据管理流程将确保及时准确地向国家阿尔茨海默病协调中心（NACC）提交数据集，并在其他外部研究人员之间共享数据。所有 UCSF ADRC 核心和项目都将提供有关研究设计和数据分析的生物统计咨询。此次咨询将对项目数据进行有效、有效的分析，解决感兴趣的研究问题。 该核心的具体目标包括（1）维护集中的 UCSF ADRC 临床和研究数据库，确保所有 UCSF ADRC 核心和项目数据的完整性、可用性和机密性； (2) 制定和维护全面的数据质量保证计划，以确保识别和解决 USCF ADRC 项目和核心的数据错误； (3) 制定和维护适当的数据管理流程，以确保及时、准确地提交 NACC 要求的所有数据集； (4) 为所有 UCSF ADRC 核心和项目提供研究设计和数据分析的统计咨询。