SYNCHROTRON SCATTERING STUDIES OF BIOMOLECULAR MATERIALS

生物分子材料的同步加速器散射研究

• 批准号: 6586784
• 负责人: CYRUS R SAFINYA
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586784
• 关键词: bioimaging /biomedical imaging; biomaterials; biomedical resource; radiography; structural biology

We propose to apply synchrotron-based small- and wide-angle x-ray scattering to characterize the structure, phase behavior, and interlayer interactions of (1) reconstituted and native self-assembled membrane-associated-proteins (maps) and (2) a fundamentally new class of biomolecular materials comprised of surfactant and associating polymers complexed with (maps). An important goal of the research is to establish a scientific basis for the intermacromolecular interactions leading to (map) self-assembly.

我们建议应用基于同步加速器的小角度和广角 X 射线 散射来表征结构、相行为和 (1)重构和天然自组装的层间相互作用 膜相关蛋白（图谱）和（2）一个全新的类别 由表面活性剂和缔合物组成的生物分子材料 与（图）复合的聚合物。 该研究的一个重要目标是 为大分子间相互作用奠定科学基础 相互作用导致（映射）自组装。