TIME RESOLVED STUDIES OF Z & I LATTICE OF SKELETAL MUSCLE

Z 的时间分辨研究

• 批准号: 6586791
• 负责人: THOMAS C IRVING
• 金额: $ 14.32万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-03-01 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6586791
• 关键词: bioimaging /biomedical imaging; biomaterials; biomedical resource; musculoskeletal system; proteins; radiography; structural biology

Active tension in striated muscle generated by the interaction of so-called crossbridges in the A-band or overlap zone of thick and thin filaments in the sarcomere is transmitted by way of the thin filaments to the Z-band which joins the sarcomere to the next one in series. The Z-band is also the site where lateral connections between fibers occur and thus is important in transmitting radial forces between them and to the plasma membrane. Our aim in this work is to examine the chronology of the structural changes that occur in the Z-band as force develops and muscle length changes by measuring the spacing of the so-called 'Z-line' equatorial reflection. So far we have been directing efforts towards evaluating and controlling radiation damage by the high photon flux delivered by the multilayer optics to the living muscle cells. We have also aquired some initial data on the effect of changing sarcomere length on Z-line spacing which show differences in Z-line behavior from the A-band lattice.

通过相互作用产生的横纹肌肉的活性张力 厚而薄 肉皮中的细丝是通过细丝的方式传播的 到Z频段，将肌膜加入了系列中的下一个。 Z波段也是纤维之间横向连接的站点 发生，因此对于在它们之间传递径向力很重要 并到质膜。 我们在这项工作中的目标是检查 Z波段中发生的结构变化的年表 通过测量的间距来发展和肌肉长度变化 所谓的“ Z线”赤道反射。 到目前为止我们已经 指导评估和控制辐射损害的努力 通过多层光学元件传递的高光子通量 活肌细胞。 我们还对 改变肌节长度对Z线间距的影响 Z线行为与A波段晶格的差异。