Core--Clinical trials /tumor procurement

核心--临床试验/肿瘤获取

• 批准号: 6563985
• 负责人: CHARLES W TAYLOR
• 金额: $ 29.68万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6563985
• 关键词: biomedical facility; clinical trials; experimental designs; human tissue; neoplasm /cancer; patient oriented research; sample collection

Description (provided by applicant) The goal of the Clinical Trials/Tumor Procurement Core is to provide expertise and quality control to assure completion of all of the clinical trial work and patient tumor sample procurement proposed in this Molecular Targets Assessment Program. The primary functions of the Clinical Trials/Tumor Procurement Core include: 1. Provide technical expertise and consultation in the design and conduct of phase I and II clinical trials of molecularly targeted anticancer agents. 2. Supervise collection and distribution of patient tumor specimens obtained by biopsy of accessible tumor sites and/or peripheral blood leukapheresis. 3. Isolate tumor cells from peripheral blood leukapheresis specimens and distribute to the appropriate laboratories for molecular target assessment. This core will provide essential services to all the projects in this grant for the collection and distribution of clinical samples from biopsied patient tissue and blood. This core will provide the program investigators with standard and novel experimental approaches to address the clinical effects of treatment with targeted therapeutics in human cancers.

描述（由申请人提供） 临床试验/肿瘤采购核心的目标是提供专业知识 和质量控制，以确保完成所有临床试验工作和 该分子靶标评估中提出的患者肿瘤样品采购 程序。临床试验/肿瘤采购核心的主要功能 包括： 1。在设计和行为方面提供技术专业知识和咨询 I阶段和II分子靶向抗癌药的临床试验。 2。监督收集和分布的患者肿瘤标本 通过可访问的肿瘤部位和/或外周血白细胞术的活检。 3。分离的肿瘤细胞来自外周血白细胞膜的样本和 分发给适当的实验室进行分子目标评估。 该核心将为这笔赠款中的所有项目提供必不可少的服务 从活检患者那里收集和分发临床样本 组织和血液。该核心将为计划调查人员提供 标准和新颖的实验方法来解决 人类癌症中有靶向治疗的治疗。