University of Buffalo Clinical and Translational Science Institute

布法罗大学临床与转化科学研究所

• 批准号: 10516562
• 负责人: Timothy F Murphy
• 金额: $ 3.42万
• 依托单位: STATE UNIVERSITY OF NEW YORK AT BUFFALO
• 依托单位国家: 美国
• 财政年份: 2015
• 资助国家: 美国
• 起止时间: 2015-08-12 至 2024-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10516562
• 关键词: Advertising; Area; Atherosclerosis; Award; Biometry; Biostatistics Core; Buffaloes; Center for Translational Science Activities; Cities; Clinic; Clinical; Clinical Research; Clinical Sciences; Clinical Trials Design; Communication; Communities; Competence; Consultations; Core Facility; Data; Databases; Development; Diverse Workforce; Educational workshop; Environment; Experimental Designs; Flow Cytometry; Foundations; Funding; Future; Gender; Good Clinical Practice; Growth; Health; Health Care Research; Health Sciences; Healthcare; Healthcare Systems; Heart; Hispanic; Individual; Influentials; Institutes; Institution; Knowledge; Laboratories; Longevity; Medical; Medical Education; Mentors; Microscope; New York; Parents; Patients; Pediatric Hospitals; Population; Process; Public Health; Public Health Informatics; Recording of previous events; Reduce health disparities; Registries; Research; Research Design; Research Institute; Research Training; Schools; Science; Series; Special Population; Speed; Strategic Planning; Testing; Training; Translational Research; Translations; Underrepresented Minority; Universities; Vision; Work; Workforce Development; biomedical informatics; community engagement; digital; education research; endothelial dysfunction; epidemiology study; ethnic diversity; experience; experimental analysis; experimental study; health disparity; improved; informatics tool; innovation; laboratory facility; medical schools; multiple data sources; next generation; novel; novel strategies; recruit; response; responsible research conduct; skills; tool; translational pipeline; volunteer; Advertising; Area; Atherosclerosis; Award; Biometry; Biostatistics Core; Buffaloes; Center for Translational Science Activities; Cities; Clinic; Clinical; Clinical Research; Clinical Sciences; Clinical Trials Design; Communication; Communities; Competence; Consultations; Core Facility; Data; Databases; Development; Diverse Workforce; Educational workshop; Environment; Experimental Designs; Flow Cytometry; Foundations; Funding; Future; Gender; Good Clinical Practice; Growth; Health; Health Care Research; Health Sciences; Healthcare; Healthcare Systems; Heart; Hispanic; Individual; Influentials; Institutes; Institution; Knowledge; Laboratories; Longevity; Medical; Medical Education; Mentors; Microscope; New York; Parents; Patients; Pediatric Hospitals; Population; Process; Public Health; Public Health Informatics; Recording of previous events; Reduce health disparities; Registries; Research; Research Design; Research Institute; Research Training; Schools; Science; Series; Special Population; Speed; Strategic Planning; Testing; Training; Translational Research; Translations; Underrepresented Minority; Universities; Vision; Work; Workforce Development; biomedical informatics; community engagement; digital; education research; endothelial dysfunction; epidemiology study; ethnic diversity; experience; experimental analysis; experimental study; health disparity; improved; informatics tool; innovation; laboratory facility; medical schools; multiple data sources; next generation; novel; novel strategies; recruit; response; responsible research conduct; skills; tool; translational pipeline; volunteer

CTSA UL1 Abstract The Buffalo Translational Consortium (BTC), which includes the University at Buffalo (UB) health sciences schools, the major healthcare institutions in our region, four key research institutes and five influential community partners, have embarked on a comprehensive strategic plan to build a strong foundation for clinical and translational research in response to our community needs. Buffalo is the second most populous city in New York State and has a rich cultural history. The proportion of underrepresented minorities in Buffalo in 2018 (50%) parallels that projected for the US in 2050, making Buffalo a microcosm of what the US will look like in 30 years. A similar proportion of our population experiences health disparities. The vision for our CTSA hub is to perform innovative research across the translational spectrum to improve the health of our community and the nation. We will develop, test and share novel approaches to engage difficult-to-engage populations and reduce health disparities in our community, which represents a “population of the future”. Guided by our vision, the CTSA has catalyzed a transformation of our environment since our CTSA was first funded in August 2015 with remarkable growth in clinical and translational research. Further, in just the past year, the UB medical school has moved into a spectacular new building and our clinical partner, Kaleida Health, the largest healthcare system in the region, opened the new Oishei Children’s Hospital, both on the Buffalo Niagara Medical Campus and connected to the Clinical and Translational Research Center devoted entirely to clinical and translational research that opened in 2012. This rapid and continuing trajectory of growth in healthcare and research in the region has resulted in a new 21st century Academic Health Center with healthcare, medical education and clinical and translational research on one campus in the heart of Buffalo, creating a foundation to enhance the impact of our CTSA even further. While launching our CTSA, we have prioritized participation in the national consortium through hosting and testing Innovation Labs as a team science tool, working with multiple hubs on initiatives to solve translational research barriers and sharing tools that we have developed with the CTSA consortium, including novel health informatics tools. Our CTSA has five ambitious but achievable aims, including: 1) Accelerate innovative translational research with teams that engage communities, regional stakeholders and the national consortium; 2) Train an excellent, diverse workforce to advance translation of discoveries; 3) Enhance inclusion of special populations across the lifespan and difficult-to-engage populations; 4) Streamline clinical research processes focusing on quality and efficiency with emphasis on multisite studies; 5) Develop, test and share biomedical informatics tools to integrate data from multiple sources to speed translation. Guided by our vision to perform research to improve the health of our community and the nation, we will continue our momentum to expand translational research, train our diverse workforce, streamline processes, engage our community, and actively contribute to the national consortium. CTSA Diversity Supplement: Bacterial Derived Aortic Endothelial Dysfunction to Promote Atherosclerosis Dayron Leya Rodriquez, the candidate for this diversity supplement is of Hispanic background and completion of this supplement award will allow him to gain academic knowledge, research skills and professional development in the areas of clinical and translational research. This proposal encompasses aims of the parent CTSA UL1 award to 1) train an excellent diverse workforce to advance translational and health-related research with 2) ehnanced inclusion of special populations. To complete the proposed supplemental research, Dayron will utilize the following CTSA cores: • Biostatistics, Epidemiology and Research Design (BERD) Core: Dayron will leverage the expertise and support of his mentor Dr. Greg Wilding (Director of BERD), for appropriate statistical experimental design and analysis of all experimental data. He will also complete the BERD Statistical workshops and BERD Clinical Trials workshops series to gain competency in aspects applicable to clinical and translational research. • Workforce Development Core: Dayron will complete workshop series (each containing 4-8 individual workshops) in the areas of a) Responsible Conduct of Research, b) Scientific Communication, c) Translational Teamwork and d) Good Clinical Practice. Following completion of each series, Dayron will be awarded a Digital Badge and with completion of all these workshops will earn his CTSI Basic Micro-credential in Clinical and Translational Reseach. • Cinical Research Facilitation Core: Dayron and our research team will work with faciltators to continue successful recruitment strategies including flyers and advertising as well as access to patient databases such as the Buffalo Research Registry to recruit local volunteers. Consultation with the Community Engagement Core will facilitate appropriate community recruitment of subjects from both genders and diverse ethnic backgrounds to increase the robustness of our subject population and collected data. • Laboratory Facility Cores. Dayron will utilize the Confocal Microscope and Flow Cytometry Facility and Next Generation Seqeuncing and Expression Facility for completion of the proposed experiments.

CTSA UL1摘要 布法罗转化联盟（BTC），其中包括布法罗大学（UB）健康科学大学 学校，我们地区的主要医疗机构，四家主要的研究机构和五个影响社区 合作伙伴已经制定了一项全面的战略计划，为临床和 响应我们社区需求的翻译研究。布法罗是新的第二大城市 约克州，有着丰富的文化历史。 2018年布法罗的代表性不足少数族裔的比例（50％） 在2050年向美国预计的相似之处，使布法罗成为30年来美国看起来的缩影。 我们的人口中有类似的比例经历健康分布。我们CTSA枢纽的愿景是执行 在翻译范围内的创新研究，以改善我们社区和国家的健康。 我们将开发，测试和共享新颖的方法，以吸引难以参与的人群并减少健康 我们社区中的差异代表了“未来的人口”。在我们的愿景的指导下，CTSA拥有 自CTSA于2015年8月首次资助以来，催化了我们环境的转变 临床和翻译研究的增长。此外，在过去的一年中，UB医学院已经搬进了 一座壮观的新建筑，我们的临床合作伙伴Kaleida Health是该地区最大的医疗保健系统， 开设了新的Oishei儿童医院，无论 临床和转化研究中心完全致力于开放的临床和翻译研究 2012年。该地区医疗保健和研究增长的这种快速而持续的轨迹导致 新的21世纪学术健康中心，医疗，医学教育以及临床和翻译 在布法罗中心的一个校园进行研究，为增强CTSA的影响创造了基础 更远。在启动我们的CTSA时，我们通过托管优先考虑参加国家财团 并测试创新实验室作为团队科学工具，与多个枢纽合作，以解决翻译的计划 我们与CTSA财团开发的研究障碍和共享工具，包括新颖的健康 信息工具。我们的CTSA具有五个雄心勃勃但可实现的目标，包括：1）加速创新 与社区，区域利益相关者和国家财团的团队翻译研究； 2）培训优秀的潜水员劳动力，以提高发现的翻译； 3）增强特殊包含 整个生命周期和难以参与的人群； 4）简化临床研究过程 专注于质量和效率，重点是多站点研究； 5）开发，测试和共享生物医学 信息工具可以将来自多个来源的数据集成到速度翻译。以我们的愿景为指导 为了改善社区和国家的健康的研究，我们将继续我们的势头 翻译研究，培训我们多样化的劳动力，简化流程，吸引我们的社区，并积极地 为国家财团做出贡献。 CTSA多样性补充：细菌衍生的主动脉内皮功能障碍可促进动脉粥样硬化 这种多样性补充的候选人Dayron Leya Rodriquez具有西班牙裔背景和完成 该补充奖项将使他能够获得学术知识，研究技能和专业人士 在临床和翻译研究领域的发展。该建议包括父母的目标 CTSA UL1奖授予1）培训优秀的潜水员劳动力，以提高转化和健康相关的研究 2）包括特殊人群。 为了完成拟议的补充研究，Dayron将利用以下CTSA核心： •生物统计学，流行病学和研究设计（BERD）核心：Dayron将利用专业知识 并支持他的心理Greg Wilding博士（BERD主任），以进行适当的统计实验设计 和所有实验数据的分析。他还将完成BERD统计研讨会和Berd临床 试验研讨会系列，以获得适用于临床和翻译研究的方面的能力。 •劳动力发展核心：Dayron将完成研讨会系列（每个都包含4-8个个人 讲习班）在a）负责任的研究领域，b）科学沟通，c）翻译 团队合作和D）良好的临床实践。 每个系列完成后，Dayron将被授予数字徽章，并完成所有这些 讲习班将获得他在临床和转化研究中的CTSI基本微观。 •电影研究促进核心：Dayron和我们的研究团队将与设施师一起继续 成功的招聘策略，包括传单和广告以及访问患者数据库 作为招募当地志愿者的水牛研究登记处。与社区参与咨询 核心将促进来自性别和潜水员种族的主题的适当社区招募 背景以增加我们受试者人群的鲁棒性并收集数据。 •实验室设施核心。 Dayron将利用共聚焦显微镜和流式细胞仪设施，以及 下一代Seqeeuncing和表达设施，用于完成提议的实验。