Core--Animal

核心--动物

• 批准号: 6563986
• 负责人: CHARLES W TAYLOR
• 金额: $ 29.68万
• 依托单位: UNIVERSITY OF ARIZONA
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-01-01 至 2002-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6563986
• 关键词: SCID mouse; animal colony; antineoplastics; biomedical facility; neoplastic growth; pharmacokinetics

Description: (provided by applicant) The purpose of the Animal Core is to provide investigators on this Molecular Targets Program access to mouse models of human tumors and to the technical expertise needed to perform these animal experiments. In the initial years of this grant, the mouse studies will involve pharmacokinetic/pharmacodynamic (PKJPD) evaluations of the drugs and their associated molecular targets as discussed in the specific projects. In future years, as new agents are presented, the Animal Core will evaluate these for antitumor activity and perform PK/PD studies in mouse models. We will primarily use severe combined immune deficient (scid) mouse models, but other mouse systems can also be used. Dr. Charles Taylor and other investigators established a scid mouse colony at the University of Arizona in 1988. Maintaining the colony locally results in tremendous cost savings compared to purchasing scid mice from commercial vendors. The Animal Core (Core C) will provide 3 primary services to the investigators on this grant: 1. Assist with the design of experiments using scid mouse models of human tumor growth and metastasis. 2. Provide technical expertise and consistency in performing scid mouse experiments. 3. Maintain the scid mouse colony and ensure adequate availability of mice for required experiments.

说明：（申请人提供） 动物核心的目的是为研究人员提供该分子 目标计划获得人类肿瘤的小鼠模型和技术 进行这些动物实验所需的专业知识。在最初的几年里 这笔资助，小鼠研究将涉及药代动力学/药效学 (PKJPD) 对药物及其相关分子靶点的评估 在具体项目中进行讨论。未来几年，随着新代理商的不断涌现 目前，Animal Core 将评估这些药物的抗肿瘤活性，并 在小鼠模型中进行 PK/PD 研究。我们将主要使用严厉的联合 免疫缺陷（scid）小鼠模型，但其他小鼠系统也可以 用过的。 Charles Taylor 博士和其他研究人员建立了 scid 小鼠 1988 年在亚利桑那大学建立殖民地。在当地维护殖民地 与购买 scid 小鼠相比，可节省大量成本 商业供应商。 动物核心（核心 C）将为调查人员提供 3 项主要服务 关于这笔补助金： 1. 协助设计人类scid小鼠模型的实验 肿瘤生长和转移。 2. 提供执行 scid mouse 的技术专业知识和一致性 实验。 3. 维护 scid 小鼠群体并确保小鼠有足够的可用性 用于所需的实验。