CORE--ANIMAL CORE

核心--动物核心

• 批准号: 6269923
• 负责人: PETER K VOGT
• 金额: $ 16.38万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-05-07 至 1999-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6269923
• 关键词: SCID mouse; animal colony; antineoplastics; athymic mouse; biomedical facility; chemical registry /resource; oncogenes

The Animal Core will be directed by Dr. Pete Vogt and Dr. David Cheresh. The major function of this core will be to examine the anti-tumor activity of compounds developed in mice bearing human tumors. Compounds developed between the Vogt/Cheresh laboratories, will target human tumor growth by targeting the oncogene function within tumor cells, while compounds developed as integrin antagonists will be used to block tumor-induced angiogenesis. The effect of blocking angiogenesis will be further analyzed in terms of anti-tumor activity in two mouse models: 1) the nude mouse model, and 2) the SCID mouse human skin chimeric model.

《动物核心》将由皮特·沃格特博士和大卫·切雷什博士执导。 该核心的主要功能是检查抗肿瘤活性 在携带人类肿瘤的小鼠中开发的化合物。开发的化合物 Vogt/Cheresh 实验室合作，将通过以下方式针对人类肿瘤生长 靶向肿瘤细胞内的癌基因功能，而化合物 开发的整合素拮抗剂将用于阻断肿瘤诱导的 血管生成。阻断血管生成的效果将进一步分析 两种小鼠模型的抗肿瘤活性：1）裸鼠 模型，2) SCID 小鼠人类皮肤嵌合模型。