Cancer genes: translating basics to applications

癌症基因：将基础知识转化为应用

• 批准号: 10079474
• 负责人: PETER K VOGT
• 金额: $ 115.41万
• 依托单位: SCRIPPS RESEARCH INSTITUTE, THE
• 依托单位国家: 美国
• 财政年份: 2016
• 资助国家: 美国
• 起止时间: 2016-01-08 至 2022-12-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/10079474
• 关键词: 1-Phosphatidylinositol 3-Kinase; Clinical Medicine; Complex; Cryoelectron Microscopy; Knowledge; Malignant Neoplasms; Molecular; Oncogenes; Oncogenic; Oncoproteins; Pathway interactions; Proteomics; Stimulus; Structure; Techniques; Translating; Translations; Untranslated RNA; mutant; novel; public health relevance; tumorigenesis

 DESCRIPTION (provided by applicant): The proposal focuses on molecular mechanisms of oncogenesis. It includes three major projects. The first deals with lncRNAs (long non-coding RNAs) that are specifically regulated by the oncoprotein MYC and by the oncogenic H1047R mutant of p110a of PI3K (phosphatidylinositol 3-kinase). The second focuses on the application of a novel and quantitative proteomic technique, QBID, to determine stimulus-specific changes in the interactomes in the PI3K pathway. The third project consists of a structural analysis of the p110-p85 complex of PI3K. Each of these projects is highly and directly cancer-relevant. Progress on these fronts will have an impact on the translation of basic knowledge into clinical medicine.

 描述（由申请人提供）：该提案重点关注肿瘤发生的分子机制，第一个项目涉及由癌蛋白 MYC 和 p110a 的致癌 H1047R 突变体特异性调节的 lncRNA（长非编码 RNA）。 PI3K（磷脂酰肌醇 3-激酶）的第二个重点是新型定量蛋白质组学技术的应用， QBID，以确定 PI3K 通路中相互作用组的刺激特异性变化。第三个项目包括对 PI3K 通路的结构分析。 PI3K 的 p110-p85 复合物。这些项目均与癌症高度直接相关。这些方面的进展将对基础知识向临床医学的转化产生影响。