Phase II COBRE in Mesenchymal and Neural Regulation of Metabolic Networks

COBRE 代谢网络间充质和神经调节的 II 期研究

基本信息

批准号：
10711692
负责人：
Lucy Liaw
金额：
$ 258万
依托单位：
MAINEHEALTH
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10711692
关键词：
Achievement Adipocytes Adipose tissue Advisory Committees Area Award Basic Science Biochemical Pathway Biology Biomedical Research Bone Marrow Cardiovascular system Career Mobility Caregivers Caring Centers of Research Excellence Chronic Clinical Research Clinical Sciences Clinical Trials Collaborations Communities Complement Core Facility Country Data Analyses Data Analytics Development Diabetes Mellitus Disease Doctor of Philosophy Education Equipment Experimental Designs Faculty Faculty Recruitment Feedback Fellowship Fostering Foundations Funding Goals Grant Growth Health Healthcare Histopathology Hospitals Infrastructure Institution Investments Knowledge Lead Leadership Maine Medical center Mentors Mentorship Mesenchymal Metabolic Metabolic Diseases Metabolism Microscopy Mission Modeling Morbidity - disease rate New England Obesity Osteoporosis Pain Patient Care Performance Phase Physiology Pilot Projects Policies Population Research Predisposition Pregnancy Pregnant Women Principal Investigator Productivity Professional Education Program Evaluation Proteomics Public Health Request for Applications Research Research Institute Research Personnel Research Project Grants Resource Sharing Resources Scientist Sensory Services Signal Transduction Smooth Muscle Student recruitment Talents Technology Time Tissues Training Training and Education Translational Research United States National Institutes of Health Universities Update Work acute care arm bariatric surgery base bone bone loss career development diabetes risk diversity and inclusion doctoral student equity, diversity, and inclusion improved instrumentation interest lipidomics member model development mortality neural neuroregulation pharmacologic population health professor programs recruit responsible research conduct rural disparities shift work skeletal student mentoring success synergism

项目摘要

Overall Program (L. Liaw PD/PI) MaineHealth Institute for Research initiated a Phase I COBRE in Mesenchymal and Neural Regulation of Metabolic Networks (COBRE in Metabolic Networks) in 2017, directed by Lucy Liaw PhD, Faculty Scientist and Professor at MaineHealth. Our Center in Phase I developed a critical mass of investigators with biomedical research interests in metabolic health and disease, focusing on adipose tissue, bone and skeletal biology, and environmental, neural, and pharmacological inputs that regulate these tissues. Our COBRE also supported three scientific core facilities – Physiology, Histopathology, and Proteomics and Lipidomics cores. These scientific core facilities provide outstanding services, and have responsibility for maintaining state-of-the-art technologies in their respective areas by updating technology, equipment, and maintaining current knowledge. In addition, scientific core facilities are responsible for the training of staff, and assisting in experimental design, project implementation and data analysis. We established a robust mentoring network for our junior investigators, and engaged an external advisory committee to evaluate projects, cores, and our overall Center. Our investment in Phase I COBRE projects and pilot projects thus far has directly yielded six NIH R01 awards (including funding of the original four junior investigator project leads) with seven COBRE members, one NSF CAREER award, one NIH S10 instrumentation grant, and one foundation research grant. Two COBRE members also mentor PhD students who were awarded NIH F31 fellowships during this time. In year four of Phase I, we held a national faculty recruitment that yielded two outstanding new junior investigators who joined our COBRE; one in August 2021 (Matt Lynes PhD), and one in August 2022 (Ziru Li PhD). In addition to Drs. Lynes and Li, Phase II includes support for a third new junior investigator project lead, Dr. Isha Agarwal. These new project leads bring expertise in thermogenic adipocytes, a gut-bone signaling axis, and impact of night shift work on diabetes risk in pregnant women. Our Phase II program will build upon our successful leadership, mentorship and professional development model. We will focus on expanding our portfolio of research and scientific resources under the guidance of an Advisory Committee. Goals for Phase II of this COBRE in Metabolic Networks are: 1) Provide leadership to evolve a robust Center infrastructure including administrative, fiscal and scientific management to support growth of collaborative research and resources in metabolic health and disease, 2) Support career advancement for COBRE investigators and alumni, 3) Maintain high quality shared scientific resources, and 4) Build a diverse research community that is guided by principles of diversity, inclusion, and equity. Successful achievement of these goals will support professional development of promising junior investigators while expanding the use of well-regarded scientific shared research resources, which are already highly utilized by a researcher user base throughout the country.

总体计划（L. LIAW PD/PI） Mainhealth Research研究所在间充质和神经调节中启动了I期毛虫 2017年，由教师科学家露西·利亚（Lucy Liaw）博士执导的代谢网络（代谢网络中的索代谢网络） MaineHealth的教授。我们的中心一阶段开发了大量的生物医学研究者对代谢健康和疾病的研究兴趣，专注于脂肪组织，骨骼和骨骼生物学以及调节这些组织的环境，神经和药物输入。我们的毛绒也支持三个科学核心设施 - 生理学，组织病理学以及蛋白质组学和脂肪组学核心。这些科学核心设施提供了出色的服务，并有责任保持最先进通过更新技术，设备和维护当前知识的技术，在各自领域的技术。此外，科学核心设施负责培训员工，并协助实验设计，项目实施和数据分析。我们为初中建立了一个强大的心理网络调查人员并与外部咨询委员会订婚，以评估项目，核心和我们的整体中心。迄今（包括最初的四个初级研究员项目的资金），有七个毛绒会员，一名NSF 职业奖，一项NIH S10仪器赠款和一项基金会研究赠款。两个毛绒在此期间，成员们还指导获得NIH F31奖学金的学生。在第四年第一阶段，我们举行了一项国家教师招聘，该招聘招募了两名出色的新初级调查员我们的山脉；一个在2021年8月（马特·莱恩斯博士），另一个在2022年8月（Ziru li Phd）。除了Drs。 Lynes和Li，第二阶段包括对第三个新的初级研究员项目负责人Isha Agarwal博士的支持。这些新项目领导带来了热脂肪细胞，肠道信号轴和夜晚影响的专业知识转移孕妇糖尿病风险的工作。我们的第二阶段计划将以我们成功的领导为基础识别和专业发展模型。我们将专注于扩大我们的研究组合和在咨询委员会的指导下的科学资源。该毛绒第二阶段的目标代谢网络是：1）提供领导才能发展出强大的中心基础架构，包括行政，财政和科学管理，以支持代谢健康中协作研究和资源的增长和疾病，2）支持山毛调查员和校友的职业发展，3）保持高质量共享的科学资源，以及4）建立一个受多样性原则的指导的潜水员研究社区，包容和公平。成功实现这些目标将支持专业发展有希望的初级调查人员，同时扩大了备受赞誉的科学共享研究资源的使用，这已经被全国研究人员用户群高度利用。

项目成果

期刊论文数量（22）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The role of Zfp467 in mediating the pro-osteogenic and anti-adipogenic effects on bone and bone marrow niche.

DOI：
10.1016/j.bone.2020.115832
发表时间：
2021-03
期刊：
Bone
影响因子：
4.1
作者：
Le PT;Liu H;Alabdulaaly L;Vegting Y;Calle IL;Gori F;Lanske B;Baron R;Rosen CJ
通讯作者：
Rosen CJ

Corrigendum: Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype.