Phase II COBRE in Mesenchymal and Neural Regulation of Metabolic Networks

COBRE 代谢网络间充质和神经调节的 II 期研究

基本信息

批准号：
10711692
负责人：
Lucy Liaw
金额：
$ 258万
依托单位：
MAINEHEALTH
依托单位国家：
美国
项目类别：
财政年份：
2017
资助国家：
美国
起止时间：
2017-09-01 至 2028-08-31
项目状态：
未结题

来源：
https://reporter.nih.gov/project-details/10711692
关键词：
Achievement Adipocytes Adipose tissue Advisory Committees Area Award Basic Science Biochemical Pathway Biology Biomedical Research Bone Marrow Cardiovascular system Career Mobility Caregivers Caring Centers of Research Excellence Chronic Clinical Research Clinical Sciences Clinical Trials Collaborations Communities Complement Core Facility Country Data Analyses Data Analytics Development Diabetes Mellitus Disease Doctor of Philosophy Education Equipment Experimental Designs Faculty Faculty Recruitment Feedback Fellowship Fostering Foundations Funding Goals Grant Growth Health Healthcare Histopathology Hospitals Infrastructure Institution Investments Knowledge Lead Leadership Maine Medical center Mentors Mentorship Mesenchymal Metabolic Metabolic Diseases Metabolism Microscopy Mission Modeling Morbidity - disease rate New England Obesity Osteoporosis Pain Patient Care Performance Phase Physiology Pilot Projects Policies Population Research Predisposition Pregnancy Pregnant Women Principal Investigator Productivity Professional Education Program Evaluation Proteomics Public Health Request for Applications Research Research Institute Research Personnel Research Project Grants Resource Sharing Resources Scientist Sensory Services Signal Transduction Smooth Muscle Student recruitment Talents Technology Time Tissues Training Training and Education Translational Research United States National Institutes of Health Universities Update Work acute care arm bariatric surgery base bone bone loss career development diabetes risk diversity and inclusion doctoral student equity, diversity, and inclusion improved instrumentation interest lipidomics member model development mortality neural neuroregulation pharmacologic population health professor programs recruit responsible research conduct rural disparities shift work skeletal student mentoring success synergism

项目摘要

Overall Program (L. Liaw PD/PI) MaineHealth Institute for Research initiated a Phase I COBRE in Mesenchymal and Neural Regulation of Metabolic Networks (COBRE in Metabolic Networks) in 2017, directed by Lucy Liaw PhD, Faculty Scientist and Professor at MaineHealth. Our Center in Phase I developed a critical mass of investigators with biomedical research interests in metabolic health and disease, focusing on adipose tissue, bone and skeletal biology, and environmental, neural, and pharmacological inputs that regulate these tissues. Our COBRE also supported three scientific core facilities – Physiology, Histopathology, and Proteomics and Lipidomics cores. These scientific core facilities provide outstanding services, and have responsibility for maintaining state-of-the-art technologies in their respective areas by updating technology, equipment, and maintaining current knowledge. In addition, scientific core facilities are responsible for the training of staff, and assisting in experimental design, project implementation and data analysis. We established a robust mentoring network for our junior investigators, and engaged an external advisory committee to evaluate projects, cores, and our overall Center. Our investment in Phase I COBRE projects and pilot projects thus far has directly yielded six NIH R01 awards (including funding of the original four junior investigator project leads) with seven COBRE members, one NSF CAREER award, one NIH S10 instrumentation grant, and one foundation research grant. Two COBRE members also mentor PhD students who were awarded NIH F31 fellowships during this time. In year four of Phase I, we held a national faculty recruitment that yielded two outstanding new junior investigators who joined our COBRE; one in August 2021 (Matt Lynes PhD), and one in August 2022 (Ziru Li PhD). In addition to Drs. Lynes and Li, Phase II includes support for a third new junior investigator project lead, Dr. Isha Agarwal. These new project leads bring expertise in thermogenic adipocytes, a gut-bone signaling axis, and impact of night shift work on diabetes risk in pregnant women. Our Phase II program will build upon our successful leadership, mentorship and professional development model. We will focus on expanding our portfolio of research and scientific resources under the guidance of an Advisory Committee. Goals for Phase II of this COBRE in Metabolic Networks are: 1) Provide leadership to evolve a robust Center infrastructure including administrative, fiscal and scientific management to support growth of collaborative research and resources in metabolic health and disease, 2) Support career advancement for COBRE investigators and alumni, 3) Maintain high quality shared scientific resources, and 4) Build a diverse research community that is guided by principles of diversity, inclusion, and equity. Successful achievement of these goals will support professional development of promising junior investigators while expanding the use of well-regarded scientific shared research resources, which are already highly utilized by a researcher user base throughout the country.

总体计划（L. Liaw PD/PI）缅因健康研究所启动了间充质和神经调节的 I 期 COBRE 代谢网络（代谢网络中的 COBRE），2017 年，由 Lucy Liaw 博士、教授科学家和缅因州健康中心教授。我们的中心在第一阶段培养了一批关键的生物医学研究人员。研究兴趣为代谢健康和疾病，重点是脂肪组织、骨和骨骼生物学，以及我们的 COBRE 也支持调节这些组织的环境、神经和药理学输入。三个科学核心设施——生理学、组织病理学、蛋白质组学和脂质组学核心。科学的核心设施提供卓越的服务，并有责任保持最先进的水平通过更新技术、设备和当前的维护知识来提高各自领域的技术。此外，科学核心设施还负责人员培训、协助实验设计、我们为初级学生建立了强大的指导网络。调查人员，并聘请外部咨询委员会来评估项目、核心和我们的整个中心。迄今为止，我们对COBRE一期项目和试点项目的投资已直接获得了六项NIH R01奖项（包括资助最初的四名初级研究员项目负责人），其中包括七名 COBRE 成员、一名 NSF 职业奖、一项 NIH S10 仪器补助金和一项基金会研究补助金两项 COBRE。成员还指导在第四年获得 NIH F31 奖学金的博士生。第一阶段，我们进行了全国教师招聘，产生了两名优秀的新初级研究员加入我们的 COBRE；一项于 2021 年 8 月（Matt Lynes 博士），一项于 2022 年 8 月（Ziru Li 博士）。 Lynes 和 Li，第二阶段包括对第三位新的初级研究员项目负责人 Isha Agarwal 博士的支持。新项目负责人带来了产热脂肪细胞、肠骨信号轴和夜间影响方面的专业知识我们的第二阶段计划将建立在我们成功的领导力基础上，我们将专注于扩大我们的研究和专业发展模式。该 COBRE 第二阶段的目标是在咨询委员会的指导下提供科学资源。代谢网络是： 1) 提供领导以发展强大的中心基础设施，包括行政、财政和科学管理支持代谢健康领域合作研究和资源的增长和疾病，2) 支持 COBRE 研究人员和校友的职业发展，3) 保持高质量共享科学资源，以及 4) 建立一个以多样性原则为指导的多元化研究社区，包容性和公平性的成功实现将支持专业发展。培养有前途的初级研究人员，同时扩大备受推崇的科学共享研究资源的使用，这些已经被全国各地的研究人员用户群高度利用。

项目成果

期刊论文数量（22）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

The role of Zfp467 in mediating the pro-osteogenic and anti-adipogenic effects on bone and bone marrow niche.

DOI：
10.1016/j.bone.2020.115832
发表时间：
2021-03
期刊：
Bone
影响因子：
4.1
作者：
Le PT;Liu H;Alabdulaaly L;Vegting Y;Calle IL;Gori F;Lanske B;Baron R;Rosen CJ
通讯作者：
Rosen CJ

Corrigendum: Suppression of Spry1 inhibits triple-negative breast cancer malignancy by decreasing EGF/EGFR mediated mesenchymal phenotype.