Human Functional Brain Anatomy

人类功能性大脑解剖学

• 批准号: 6419322
• 负责人: GREGORY MCCARTHY
• 金额: $ 139.56万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6419322
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; brain imaging /visualization /scanning; functional magnetic resonance imaging; neuroanatomy; neuropsychology

DESCRIPTION (provided by applicant) This Program Project will investigate the functional neuroanatomy of the human brain using high-field functional magnetic resonance imaging (functional MRI), electrophysiology, and behavior. The four scientific projects are strongly linked by their focus on the relationship between brain and behavior. The projects are organized into a logical progression from sensory processing through response selection. Project 1 considers the relationship between performance in elemental visual psychophysical tasks and the quantitative structural anatomy of primary visual cortex (Vl). This project is technically challenging and depends upon high-resolution fMRI-based retinotopic mapping to discriminate V1 from other visual areas. Project 2 also focuses upon early visual processing, however its emphasis is upon changes in processing as a function of directed attention. Project 3 builds directly upon Project 2 by investigating the domain specificity (space or feature) of attended visual attributes that must be maintained in a transient memory store for later processing. Project 3 also investigates the role of response processing and sequential expectancies in prefrontal cortex. Project 4 will investigate the manner in attention is attracted automatically or reflexively by novel and/or distracting stimuli. The scientific projects are supported by three Cores. Core A is administrative. Core B will develop methods in high-field functional MRI designed to improve the functional resolution of brain imaging. This core will develop and implement methods to improve the specificity of the MR signal to brain parenchyma, to recover signal lost to large scale susceptibility artifacts in ventral frontal and medial temporal regions, and to improve the spatial and temporal resolution of BOLD contrast. Core C will develop and implement methods for experimental control, physiological monitoring, and analysis of structural and functional image data.

描述（由申请人提供） 该计划项目将研究人类的功能性神经解剖学 大脑使用高场功能性磁共振成像（功能性MRI）， 电生理学和行为。这四个科学项目非常强烈 他们关注大脑与行为之间的关系。这 从感觉处理中将项目组织成逻辑的进步 通过响应选择。项目1考虑 元素视觉心理物理任务和定量的表现 原发性皮层（VL）的结构解剖结构。这个项目在技术上是 具有挑战性并取决于基于功能磁共振毒的高分辨率的视网膜映射到 区分V1与其他视觉区域。项目2还重点介绍 视觉处理，但是它的重点是处理的变化 指导注意的功能。项目3直接基于项目2 调查参加视觉的域特异性（空间或特征） 必须在瞬态内存存储中维护的属性以供以后 加工。项目3还调查了响应处理和 前额叶皮层的顺序预期。项目4将调查 注意力被小说和/或自动吸引 分散注意力的刺激。科学项目得到了三个核心的支持。核 A是行政。核心B将在高场功能性MRI中开发方法 旨在改善大脑成像的功能分辨率。这个核心将 开发和实施方法以提高MR信号的特异性 脑实质，以恢复损失到大规模敏感性的信号 腹侧额叶和内侧颞区的伪影，并改善 大胆对比的空间和时间分辨率。核心将发展和 实施实验控制，生理监测和 分析结构和功能图像数据。