Human Functional Brain Anatomy

人类功能性大脑解剖学

• 批准号: 6529696
• 负责人: GREGORY MCCARTHY
• 金额: $ 141.41万
• 依托单位: DUKE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-30 至 2006-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6529696
• 关键词: behavioral /social science research tag; bioimaging /biomedical imaging; brain imaging /visualization /scanning; functional magnetic resonance imaging; neuroanatomy; neuropsychology

DESCRIPTION (provided by applicant) This Program Project will investigate the functional neuroanatomy of the human brain using high-field functional magnetic resonance imaging (functional MRI), electrophysiology, and behavior. The four scientific projects are strongly linked by their focus on the relationship between brain and behavior. The projects are organized into a logical progression from sensory processing through response selection. Project 1 considers the relationship between performance in elemental visual psychophysical tasks and the quantitative structural anatomy of primary visual cortex (Vl). This project is technically challenging and depends upon high-resolution fMRI-based retinotopic mapping to discriminate V1 from other visual areas. Project 2 also focuses upon early visual processing, however its emphasis is upon changes in processing as a function of directed attention. Project 3 builds directly upon Project 2 by investigating the domain specificity (space or feature) of attended visual attributes that must be maintained in a transient memory store for later processing. Project 3 also investigates the role of response processing and sequential expectancies in prefrontal cortex. Project 4 will investigate the manner in attention is attracted automatically or reflexively by novel and/or distracting stimuli. The scientific projects are supported by three Cores. Core A is administrative. Core B will develop methods in high-field functional MRI designed to improve the functional resolution of brain imaging. This core will develop and implement methods to improve the specificity of the MR signal to brain parenchyma, to recover signal lost to large scale susceptibility artifacts in ventral frontal and medial temporal regions, and to improve the spatial and temporal resolution of BOLD contrast. Core C will develop and implement methods for experimental control, physiological monitoring, and analysis of structural and functional image data.

描述（由申请人提供） 该计划项目将研究人类的功能神经解剖学 使用高场功能磁共振成像（功能性 MRI）对大脑进行研究， 电生理学和行为学。四大科研项目实力雄厚 他们对大脑与行为之间关系的关注联系在一起。这 项目被组织成从感官处理开始的逻辑进程 通过响应选择。项目 1 考虑了之间的关系 基本视觉心理物理任务的表现和定量 初级视觉皮层（VI）的结构解剖学。该项目在技术上 具有挑战性，并且依赖于基于高分辨率功能磁共振成像的视网膜专题映射 将 V1 与其他视觉区域区分开来。项目2也侧重于早期 视觉处理，然而它的重点是处理过程的变化 定向注意功能。项目 3 直接基于项目 2 构建 研究参与视觉的领域特异性（空间或特征） 必须在临时内存存储中维护以供以后使用的属性 加工。项目 3 还研究了响应处理和 前额皮质的连续预期。项目4将调查 注意力的方式自动地或条件反射地被小说和/或 分散注意力的刺激。这些科学项目由三个核心支持。核 A是行政性的。 Core B 将开发高场功能 MRI 方法 旨在提高大脑成像的功能分辨率。该核心将 开发并实施提高 MR 信号特异性的方法 脑实质，恢复因大规模敏感性而丢失的信号 腹侧额叶和内侧颞区的伪影，并改善 BOLD 对比度的空间和时间分辨率。 Core C 将开发并 实施实验控制、生理监测和 结构和功能图像数据的分析。