An interdisciplinary approach to ADHD.

多动症的跨学科方法。

• 批准号: 7159060
• 负责人: L. Cinnamon Bidwell
• 金额: $ 3.02万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2006
• 资助国家: 美国
• 起止时间: 2006-07-01 至 2009-06-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7159060
• 关键词: attention deficit disorder; behavioral /social science research tag; behavioral genetics; bioimaging /biomedical imaging; brain imaging /visualization /scanning; brain mapping; brain morphology; cerebellum; clinical research; corpus striatum; executive function; genetic susceptibility; human genetic material tag; human subject; impulsive behavior; magnetic resonance imaging; neuropsychological tests; predoctoral investigator; prefrontal lobe /cortex; psychopathology; short term memory; university student

DESCRIPTION (provided by applicant): The applicant proposes a study aimed at delineating associations between executive processes, genes, and frontalstriatal brain structure in attention deficit hyperactivity disorder (ADHD). ADHD is associated with well- documented weaknesses in executive processing, including deficits in response inhibition (Rl) and working memory (WM). Evidence suggests that these deficits may be heritable and sensitive to genetic control. In addition, research has begun to characterize the specific neural substrates that mediate these executive processes. Given promising evidence for mediation of Rl and WM through genetic influences and neural pathways, these executive processes may be useful intermediate phenotypes for determining genetic and neural etiologies of ADHD. The proposed study involves collecting neuropsychological data in the domains of Rl and WM, genetic material, and anatomical brain images (as part of an ongoing functional magnetic resonance imaging study) from adults with ADHD and control participants. Specific associations between task performance, genotypes, volumes of putatively involved brain regions, and ADHD symptoms will be investigated. Findings will characterize the contributions of genetic variations and neural structures on executive processing in ADHD, as well as identify potentially useful genetic and neural intermediate phenotypes for future genetic studies of ADHD.

描述（由申请人提供）：申请人提出了一项研究，旨在描绘注意力缺陷多动障碍（ADHD）中的执行过程、基因和额叶纹状体大脑结构之间的关联。 ADHD 与执行处理中的缺陷有关，包括反应抑制 (Rl) 和工作记忆 (WM) 缺陷。有证据表明这些缺陷可能是遗传性的并且对基因控制敏感。此外，研究已经开始表征介导这些执行过程的特定神经基质。鉴于通过遗传影响和神经通路介导 R1 和 WM 的有希望的证据，这些执行过程可能是确定 ADHD 遗传和神经病因的有用的中间表型。拟议的研究涉及从患有 ADHD 的成人和对照参与者中收集 R1 和 WM 领域的神经心理学数据、遗传物质和解剖脑图像（作为正在进行的功能性磁共振成像研究的一部分）。将研究任务表现、基因型、可能涉及的大脑区域的体积和多动症症状之间的具体关联。研究结果将描述遗传变异和神经结构对 ADHD 执行处理的贡献，并为未来 ADHD 的遗传学研究确定潜在有用的遗传和神经中间表型。