ERP studies of acute influences of THC and CBD on memory encoding and retrieval processes

THC 和 CBD 对记忆编码和检索过程的急性影响的 ERP 研究

• 批准号: 10624345
• 负责人: L. Cinnamon Bidwell
• 金额: $ 64.83万
• 依托单位: UNIVERSITY OF COLORADO
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-08-01 至 2026-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10624345
• 关键词: Acute; Adverse effects; Blood; Brain; Cannabidiol; Cannabinoids; Cannabis; Cannabis retail; Climate; Cognitive; Collection; Data; Dissociation; Episodic memory; Event; Familiarity; Goals; Harm Reduction; Impairment; Intoxication; Learning; Legal; Marketing; Measures; Medical; Medical Marijuana; Medicine; Memory; Monitor; Participant; Performance; Pharmacology; Phase; Policies; Policy Maker; Process; Property; Randomized; Recreation; Relative Risks; Research; Retrieval; Risk Assessment; Role; Self Administration; Stimulus; Testing; Tetrahydrocannabinol; Variant; Work; cognitive function; design; endogenous cannabinoid system; experimental study; high risk; indexing; knowledge base; marijuana use; marijuana user; memory encoding; memory process; memory recognition; memory retrieval; verbal

Project Summary Previous research has documented acute harmful effects of cannabis use on verbal episodic memory, but prior work has not sufficiently considered that the memory effects of cannabis are the compound action of different cannabinoids acting on different memory processes. Specifically, cannabidiol (CBD), a non-psychotomimetic component of cannabis (doesn’t produce a “high”), is thought to have cognitively protective properties and may mitigate some harmful effects of ∆9-tetrahydrocannabinol (THC). Preliminary data, including our own, suggest that THC and CBD render differential effects on memory. Further, few prior studies have tested high potency strains that are commonly available. Our global hypothesis is that the effects of cannabis on memory vary as a function of the ratio of CBD to THC, with THC having adverse effects that may be counteracted by CBD. The goal of this study is to test the effects of three real-world commercially available cannabis strains that differ markedly in their ratio of CBD to THC. To that end, we will test the effects of -THC/+CBD (0% THC/16% CBD), +THC/-CBD (16% THC/0% CBD), and +THC/+CBD (16% THC/16% CBD) strains on recognition memory as well as event-related brain potentials (ERPs) that have previously been found to be related to different underlying memory processes. We use a naturalistic observational design in which each participant will complete the same memory task while intoxicated one day and not intoxicated another day (order counterbalanced). Aim 1 (Experiment 1) will assess recognition memory performance and memory-related ERP components in cannabis users after self-administration of one of three randomly assigned cannabis strains (+THC/-CBD vs. -THC/+CBD vs. +THC/+CBD) during both memory encoding (learning) and memory retrieval. Aims 2 and 3 will dissociate the effects of cannabis on memory encoding vs. retrieval processes. The effects of the three strains will be tested when users are acutely intoxicated only during memory retrieval (Aim 2, Experiment 2) or when users are intoxicated only during memory encoding (Aim 3, Experiment 3). We hypothesize a step wise effect of strain in each experiment such that the +THC/-CBD group will demonstrate the largest decrement in memory accuracy, as compared to the +THC/+CBD group, which will show a larger memory decrement than the -THC/+CBD group. In addition to strain assignment, CBD and THC blood levels will also be tested in relation to memory accuracy, with greater CBD/THC levels associated with higher/lower memory accuracy. We further predict that memory-related ERP components recorded during encoding and retrieval will show strain and blood level effects paralleling accuracy, with variations in these effects indicating the relative influences on different memory subprocesses (encoding, familiarity, recollection, post-retrieval monitoring). This study is critical in today’s climate of rapid legal changes and increased cannabis use for both recreational and medicinal purposes. Timely and accurate data on the impact of real-world cannabis on memory processes is critical in order to reduce the harms and identify the benefits of widespread legalization.

项目摘要 先前的研究已经记录了大麻使用对言语情节记忆的急性有害影响，但之前 工作尚未充分考虑到大麻的记忆效应是不同的复合作用 大麻素作用于不同的记忆过程。具体而言，大麻二酚（CBD），一种非精神病学 大麻的组成部分（不要产生“高”），被认为具有认知保护的特性，可以 减轻Δ9-四氢大麻醇（THC）的一些有害作用。包括我们自己的包括我们的初步数据建议 THC和CBD对记忆产生差异影响。此外，很少有研究测试高效力 通常可用的菌株。我们的全球假设是，大麻对记忆的影响因 CBD与THC之比的功能，THC具有不良反应，可能由CBD抵消。这 这项研究的目的是测试三种市售大麻菌株的影响 CBD与THC的比率显着。为此，我们将测试-THC/+CBD（0％THC/16％CBD）的影响， +THC/-CBD（16％THC/0％CBD）和 +THC/ +CBD（16％THC/16％CBD）识别记忆菌株 以及与事件相关的大脑电位（ERP），以前已被发现与不同 基础记忆过程。我们使用自然主义的观察设计，每个参与者都会 一天氧基化的一天，而不是一天不氧化的同一记忆任务（顺序 平衡）。 AIM 1（实验1）将评估识别记忆性能和与内存有关的识别 在三个随机分配的大麻中的一个自我管理后，大麻使用者中的ERP组件 在内存编码（学习）和内存期间，应变（+THC/-CBD vs. -THC/+CBD vs.+THC/+CBD） 检索。目标2和3将分离大麻对编码和检索过程的记忆的影响。这 只有在记忆检索期间，当用户急性陶醉时，这三种菌株的效果将进行测试（AIM 2，实验2）或仅在记忆编码期间使用用户陶醉时（AIM 3，实验3）。我们 假设每个实验中应变的阶梯效应，以便 +THC/-CBD组证明 与 +THC/ +CBD组相比，记忆精度的最大降低最大 与-THC/+CBD组相比，记忆力下降。除了应变分配外，CBD和THC血液水平 还将根据记忆准确性进行测试，较高的CBD/THC水平与较高/较低有关 内存准确性。我们进一步预测，编码期间记录的与内存相关的ERP组件 检索将显示平行精度的应变和血液水平效应，这些效果的变化表明 相对影响对不同内存子过程的影响（编码，熟悉，回忆，接下来 监视）。这项研究对于当今的快速法律变化和增加大麻使用的气氛至关重 娱乐和医疗目的。及时，准确的数据关于现实世界大麻的影响 记忆过程对于减少危害并确定宽度合法化的好处至关重要。