Morphologic Characterization of Carotid Artery Plaque Using Virtual Angioscopy

使用虚拟血管镜检查颈动脉斑块的形态特征

• 批准号: 6431759
• 负责人: Ronald M. Summers
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/6431759
• 关键词: anatomy; angiography; atherosclerotic plaque; blood vessels; carotid artery; cerebrovascular disorder diagnosis; cerebrovascular imaging /visualization; clinical research; computed axial tomography; computer assisted diagnosis; computer simulation; diagnosis quality /standard; disease /disorder model; dogs; endotoxins; human subject; image processing; interview; magnetic resonance imaging; noninvasive diagnosis; oxygen consumption; pathologic process

This project explores the efficacy of a new diagnostic method for evaluating the vasculature known as virtual angioscopy (VA). VA is performed by acquiring high-resolution images of the blood vessels of interest, using either computed tomography or magnetic resonance (MR) images. These images are used to generate a three-dimensional (3D) model of the blood vessel wall on a graphics workstation. The model can be manipulated to allow the viewer to "fly through" the blood vessel, providing views similar to those obtained during angioscopy. The technique produces a display of human arterial and venous anatomy in a readily understood format. Moreover, it may allow investigation of vascular stenosis and atherosclerotic plaques. The research literature suggests that plaque morphology may be an important determinant of the incidence of stroke and transient ischemic attack. Patients studied in this protocol will have known atherosclerotic plaque in the region of the carotid bulb and will have been referred for carotid endarterectomy. The surgery will be done at Georgetown University Hospital or the National Naval Medical Center, and the imaging will be done in the NIH Clinical Center Department of Radiology. The study design consists of high resolution MR scanning of the neck followed by 3D surface rendering of the carotid arteries. Plaque morphology will be compared to pathologic analysis. We anticipate that VA will yield new insights into plaque morphology. Despite collaborations with the National Institute of Neurological Disorders and Stroke (T.J. DeGraba, M.D.) to ensure increased patient accrual, we have had difficulty recruiting patients due to the need for the patients to have MR image scans just before major surgery at another hospital. This project was terminated in November 1999.

该项目探讨了一种新诊断方法评估称为虚拟血管镜检查（VA）的脉管系统的功效。 VA是通过使用计算机断层扫描或磁共振（MR）图像获取感兴趣的血管的高分辨率图像来进行的。这些图像用于生成图形工作站上血管壁的三维（3D）模型。可以操纵该模型以使观众可以“飞过”血管，从而提供类似于血管镜检查中获得的视图。该技术以一种容易理解的格式产生人类动脉和静脉解剖结构。此外，它可以允许研究血管狭窄和动脉粥样硬化斑块。研究文献表明，斑块形态可能是中风和短暂性缺血性发作发生率的重要决定因素。在该方案中研究的患者将在颈动脉灯泡区域中知道动脉粥样硬化斑块，并将被转诊为颈动脉内膜切除术。该手术将在乔治敦大学医院或国家海军医疗中心进行，该影像学将在NIH临床放射学院进行。研究设计包括颈部的高分辨率MR扫描，然后是颈动脉的3D表面渲染。斑块形态将与病理分析进行比较。我们预计VA将产生对斑块形态的新见解。尽管与国家神经系统疾病和中风研究所合作（医学博士T.J. Degraba），以确保患者的应计增加，但由于患者需要在另一家医院进行大规模手术之前进行MR图像扫描，我们仍很难招募患者。该项目于1999年11月终止。