Diagnostic Efficacy Of Virtual Bronchoscopy

虚拟支气管镜的诊断效果

• 批准号: 7006006
• 负责人: Ronald M. Summers
• 金额: --
• 依托单位: CLINICAL CENTER
• 依托单位国家: 美国
• 资助国家: 美国
• 起止时间: 至
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/7006006
• 关键词: bioimaging /biomedical imaging; bronchoscopy; bronchus; bronchus disorder; clinical research; computed axial tomography; computer assisted diagnosis; computer simulation; diagnosis design /evaluation; diagnosis quality /standard; digital imaging; fiber optics; human subject; image guided surgery /therapy; infection; inflammation; lung imaging /visualization /scanning; lung neoplasms; neoplasm /cancer diagnosis; noninvasive diagnosis; patient oriented research; respiratory disorder diagnosis; thoracic radiography; thorax neoplasm; videotape /videodisc

This project is a test of the efficacy of a new diagnostic method for imaging the airways known as virtual bronchoscopy. Virtual Bronchoscopy is performed by acquiring thin section computer tomography (CT) images of the chest. These images are used to generate a three-dimensional (3D) model of the tracheal and bronchial walls on a graphics workstation in 3D. The model can be manipulated to allow the viewer to "fly-through" the tracheobronchial tree providing views similar to those obtained using bronchoscopy. The technique produces a display of the human bronchial system in a readily understood format. Moreover, it allows investigation of post-stenotic portions of the bronchial tree that are beyond the reach of fiberoptic bronchoscopy. Further, virtual bronchoscopy may be used to guide interventional procedures. The patients that will be studied in this protocol will be those having inflammatory, infectious, or neoplastic pulmonary processes who would have had chest CT for clinical reasons. These patients will be recruited from current NIH protocols. The study design consists of scanning of the thorax using thin section helical CT, followed by three dimensional surface rendering of the airways and transfer of the digital data to videotape. In one of four parts of the protocol, the virtual bronchoscopy will be compared with results from fiberoptic bronchoscopy in a blinded study. In a second part of the protocol, the virtual bronchoscopy will be used to perform a descriptive analysis of cavity lung lesions. In the third part, the utility of virtual bronchoscopy in diagnosis of neoplastic lesions of the chest will be studied. In the fourth part, certain technical problems in the virtual bronchoscopy procedure will be investigated. The patients will only have fiberoptic bronchoscopy for clinically indicated purposes. We anticipate that virtual bronchoscopy will be diagnostically efficacious for disorders which produce a morphologic alteration in bronchial anatomy. There have been no complications. Virtual bronchoscopy has been shown to be useful for detecting stenoses. We now have access to a CT scanner with higher Z-axis resolution and are investigating its efficacy for virtual bronchoscopy.

该项目是对一种新诊断方法对空气道（称为虚拟支气管镜检查）进行成像的功效的测试。虚拟支气管镜检查是通过获取胸部的薄截面计算机断层扫描（CT）图像来进行的。这些图像用于生成3D图形工作站上气管和支气管壁的三维（3D）模型。可以操纵该模型，以使观众可以“直飞”气管对树，从而提供类似于使用支气管镜检查的视图。该技术以一种容易理解的格式生成人类支气管系统的显示。此外，它允许研究支气管树的延伸后部分，这些部分无法触及纤维支气管镜检查。此外，虚拟支气管镜检查可用于指导介入程序。将在该方案中进行研究的患者将是那些患有炎症，传染性或肿瘤性肺部过程的患者，他们出于临床原因将患有胸部CT。这些患者将从当前的NIH方案中招募。研究设计包括使用薄截面螺旋CT扫描胸腔，然后是气道的三维表面渲染以及将数字数据传输到录像带。在协议的四个部分之一中，将在一项盲研究中将虚拟支气管镜检查与光纤支气管镜检查的结果进行比较。在协议的第二部分中，虚拟支气管镜检查将用于对腔肺部病变进行描述性分析。在第三部分中，将研究虚拟支气管镜检查诊断胸部肿瘤病变的实用性。在第四部分中，将研究虚拟支气管镜检查过程中的某些技术问题。患者仅用于临床指示的目的。我们预计虚拟支气管镜检查将对产生支气管解剖学形态学改变的疾病有效。没有并发症。虚拟支气管镜检查已被证明可用于检测狭窄。现在，我们可以使用具有较高Z轴分辨率的CT扫描仪，并正在研究其对虚拟支气管镜检查的功效。