Mapping Basal Ganglia Function During Motor Sequencing

运动排序过程中绘制基底神经节功能

• 批准号: 6528038
• 负责人: VINOD MENON
• 金额: $ 7.85万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-09-15 至 2003-08-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6528038
• 关键词: auditory stimulus; basal ganglia; behavior test; behavioral /social science research tag; brain mapping; cerebellum; clinical research; fingers; functional magnetic resonance imaging; human subject; limb movement; neural information processing; neuroimaging; psychomotor function; psychomotor reaction time; sensorimotor system; visual stimulus

DESCRIPTION:(provided by applicant) The basal ganglia are thought to play a critical role in adaptive behavior and cognition in general, and movement preparation, initiation, control and sequencing in particular. However, the relative contributions and roles of the various sub-components of the basal ganglia are not known. The overarching goal of this proposal is to characterize the differential contributions of dorsal basal ganglia (dBG) nuclei during the sequential organization of behavior. The proposed study aims to extend and amplify our previous findings of reliable and differential fMRI activation of the anterior caudate, anterior and posterior putamen and globus pallidus during movement sequencing. We plan to investigate in greater detail dBG involvement in various specific components of movement sequencing, and to examine the relationship between dBG activation, overall behavior, and specific behavioral performance measures such as reaction time and accuracy. Although the primary focus of this study is the dBG, the relative signal change, spatial extent and time course of activation in neocortical motor areas and the cerebellum will be also be examined. In addition, functional relations between the posterior putamen and globus pallidus, thalamus, cerebellum and cortical motor areas receiving dBG output will also be examined. Study 1 will investigate dBG function during movement sequencing in relation to specific and measurable changes in behavior. We will examine the effect of rate of movement on dBG activation during sequencing of unpredictable and predictable movements. Study 2 will investigate dBG function in relation to specific components involved in motor control during movement sequencing using event-related fMRI. Together these studies will more convincingly relate dBG to behavior during movement sequencing. More broadly, contrasting the roles of the dBG, motor cortex, SMA, pre-SMA and the cerebellum will yield significant information about distributed brain processes involved in the sequential organization of behavior. Results from the proposed studies will provide additional insights regarding the role of the dBG in adaptive behavior. Furthermore, the proposed research will aid in understanding and treating basal ganglia disorders, such as schizophrenia, ADHD, Huntington's disease, Parkinson's disease, and Tourette's syndrome.

描述：（申请人提供） 认为基底神经节在适应性行为中起着至关重要的作用 认知一般以及运动的准备，启动，控制和 特别是测序。但是，相对的贡献和角色 基底神经节的各种子兼容性尚不清楚。总体目标 该提议的特征是表征背侧的差异贡献 在行为顺序组织期间，基底神经节（DBG）核。这 拟议的研究旨在扩展和扩大我们以前的可靠发现和 前尾状，前后的差异FMRI激活 运动测序期间的梭子鱼和果胶pallidus。我们计划调查 更详细的DBG参与运动的各种特定组成部分 测序并检查DBG激活之间的关系 行为和特定的行为绩效指标，例如反应时间 和准确性。尽管这项研究的主要重点是DBG，但相对 新皮质激活的信号变化，空间范围和时间过程 还将检查运动区域和小脑。此外， 后壳和Globus Pallidus之间的功能关系， 丘脑，小脑和接收DBG输出的皮质运动区域也将是 检查。研究1将研究运动测序期间的DBG功能 与特定和可测量的行为变化有关。我们将检查 运动速率对无法预测的测序期间DBG激活的影响 和可预测的运动。研究2将研究DBG功能 在运动测序期间，使用的特定组件使用 与事件有关的fMRI。 这些研究共同将DBG与行为更具说服力 运动测序。更广泛地，将DBG，电动机的作用对比 皮层，SMA，前SMA和小脑将产生重要信息 关于连续组织涉及的分布式大脑过程 行为。拟议研究的结果将提供其他见解 关于DBG在适应性行为中的作用。此外，提议 研究将有助于理解和治疗基底神经节疾病，例如 作为精神分裂症，多动症，亨廷顿氏病，帕金森氏病和 图雷特综合症。