Neuroimaging Cognition in Adolescent Behavior Disorders

青少年行为障碍的神经影像认知

• 批准号: 7261986
• 负责人: Michael C Stevens
• 金额: $ 16.29万
• 依托单位: HARTFORD HOSPITAL
• 依托单位国家: 美国
• 财政年份: 2004
• 资助国家: 美国
• 起止时间: 2004-08-01 至 2009-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7261986
• 关键词: Address; Adolescence; Adolescent; Adolescent Behavior; Adult; Affect; Affective; Amygdaloid structure; Anterior; Area; Attention deficit hyperactivity disorder; Basal Ganglia; Behavior; Behavior Disorders; Behavioral; Behavioral Symptoms; Bilateral; Biological; Bone callus; Brain; Brain imaging; Cerebellum; Child; Classification; Clinical assessments; Cognition; Cognitive; Cognitive deficits; Collection; Comorbidity; Conduct Disorder; Corpus striatum structure; DSM-IV; Data; Detection; Development; Diagnosis; Diagnostic; Disease; Disinhibition; Disruptive Behavior Disorder; Electrodes; Electroencephalography; Elements; Emotional; Evaluation; Event; Event-Related Potentials; Functional Magnetic Resonance Imaging; Functional disorder; Funding Mechanisms; Imaging Techniques; Impaired cognition; Impairment; Inferior; Influentials; Lateral; Left; Measures; Monitor; Morbidity - disease rate; Motor; Neurobiology; Neurocognition; Neurocognitive; Neurocognitive Deficit; Neurophysiology - biologic function; Neuropsychological Tests; Pattern; Performance; Pilot Projects; Prefrontal Cortex; Process; Prospective Studies; Purpose; Relative (related person); Research; Research Personnel; Research Project Grants; Research Technics; Resources; Risk; Site; Social Environment; Superior temporal gyrus; Symptoms; System; Test Result; Time; Training; anti social; auditory stimulus; base; behavior disorder diagnosis; design; disorder control; experience; hemodynamics; indexing; lexical; millisecond; neural circuit; neuroimaging; neuropsychological; programs; psychopathic personality; relating to nervous system; response; skills; stem; stimulus processing; theories; trait

DESCRIPTION (provided by applicant): Over a 5-year period, I will receive training in event-related potential electroencephalography (ERP EEG), event-related functional magnetic resonance imaging (ER-fMRI), and neuropsychological research techniques with adolescents who have disruptive behavior disorders (DBDs). The purpose of this research is to identify and characterize neurocognitive correlates of traits and behaviors that comprise commonly used classification systems for juvenile DBDs. These training experiences will prepare me to implement a pilot study of DBD brain function in 125 adolescents over the RCA period. It will include functional brain imaging using ERP and ER-fMRI versions of several different tasks designed for sensitivity to neural dysfunction unique to each DBD diagnoses. Previous studies have poorly controlled for the common comorbidity seen in DBD subjects; none have incorporated all the recruitment resources and the brain imaging techniques proposed in this project. These data will isolate abnormally functioning neural circuits underlying cognitive abnormalities in antisocial adolescents, compare DBD groups and/or symptom types, and determine associations of these findings to behavioral and neuropsychological measures commonly used in clinical assessment. Through the process of training and pilot research, I will develop: (1) expertise in collection, analysis, and interpretation of ERPs and ER-fMRI; (2) expertise in neuropsychological evaluation of antisocial adolescents using developmentally-appropriate measures; and (3) expertise in theories of cognitive dysfunction in DBDs, including what specific mechanisms may underlie symptoms or affect the course of cognitive development of antisocial children into adulthood. With this training and the collection of pilot data I hope to develop an empirically based conceptual framework and the necessary methodological skills to preliminarily address several questions related to juvenile antisocial disorders, including: What neural dysfunction is specific to each adolescent DBD diagnosis? What relationship do DBD adolescents' EEG and ER-fMRI-measured brain activity have with behavioral profile or neuropsychological test results? How do findings compare with neuroimaging results from previous studies of antisocial groups? The overall aim of this project is to prepare me to conduct subsequent prospective studies of DBD adolescents to study changes in neurocognition from adolescence to adulthood using R01 funding mechanisms.

描述（由申请人提供）：在5年的时间内，我将接受与事件相关的潜在脑电图（ERP EEG），与事件相关的功能磁共振成像（ER-FMRI）和神经心理学研究技术的培训破坏性行为障碍（DBD）。这项研究的目的是识别和表征构成少年DBD的常用分类系统的性状和行为的神经认知相关性。这些培训经验将使我在RCA期间在125名青少年中实施DBD脑功能的试点研究。它将包括使用ERP和ER-FMRI版本的功能性脑成像的几种不同任务，旨在敏感到每个DBD诊断所特有的神经功能障碍。先前的研究对DBD受试者中的常见合并症的控制很差。没有人纳入该项目中提出的所有招聘资源和大脑成像技术。这些数据将隔离反社会青少年的认知异常的异常功能，比较DBD组和/或症状类型，并确定这些发现与临床评估中常用的行为和神经心理学指标的关联。通过培训和试点研究的过程，我将发展：（1）ERP和ER-FMRI的收集，分析和解释方面的专业知识； （2）使用适当的发展措施对反社会青少年进行神经心理学评估的专业知识； （3）DBD认知功能障碍理论的专业知识，包括哪些特定机制可能是症状的基础或影响反社会儿童的认知发展的过程。通过这种培训和试点数据的收集，我希望开发一个基于经验的概念框架以及初步解决与少年反社会疾病有关的几个问题的必要方法学技能，包括：哪些神经功能障碍是针对每个青少年DBD诊断的特定的？ DBD青少年的EEG和ER-FMRI测量的大脑活动与行为概况或神经心理学测试结果有什么关系？发现与先前对反社会组的研究的神经影像学结果相比如何？该项目的总体目的是使我准备对DBD青少年进行后续的前瞻性研究，以使用R01融资机制研究从青春期到成年的神经认知的变化。