Neural Architecture of Emotion Regulation, Adolescent Development and Depression

情绪调节、青少年发展和抑郁的神经结构

基本信息

批准号：
9477913
负责人：
Michael C Stevens
金额：
$ 8.16万
依托单位：
HARTFORD HOSPITAL
依托单位国家：
美国
项目类别：
财政年份：
2014
资助国家：
美国
起止时间：
2014-12-15 至 2018-08-31
项目状态：
已结题

来源：
https://reporter.nih.gov/project-details/9477913
关键词：
Acute Adolescent Adolescent Development Affective Age Amygdaloid structure Anxiety Disorders Architecture Biological Markers Biological Neural Networks Brain Brain region Chronic Cognitive Complex Conscious Cues Data Depressed mood Diagnosis Disease Disease remission Down-Regulation Eating Disorders Emotional Emotional disorder Emotions Family Feeling Functional Magnetic Resonance Imaging Functional disorder Future Goals Image Impairment Individual Differences Knowledge Link Major Depressive Disorder Measures Mediating Mental Depression Mental disorders Methods Modeling Mood Disorders Nature Neural Network Simulation Neurobiology Participant Pathway interactions Patient Self-Report Patients Personality Physiological Predisposition Prefrontal Cortex Psychopathology Public Health Reaction Recording of previous events Recurrence Research Risk Selective Serotonin Reuptake Inhibitor Series Severities Stimulus Subgroup Symptoms System Teenagers Testing Work base brain dysfunction causal model child depression cognitive reappraisal disorder control disorder risk emotion regulation emotional experience gain of function imaging study network architecture network dysfunction neuroimaging neuroregulation novel positive emotional state public health relevance relating to nervous system response sex success tool trait treatment duration

项目摘要

DESCRIPTION (provided by applicant): The project goals are to use functional MRI along with functional/effective connectivity analysis tools to better characterize neural networks involved in emotion regulation (ER) and to identify ER network abnormalities in adolescent Major Depressive Disorder (MDD) - a highly prevalent, recurrent psychiatric disorder whose debilitating and typically chronic nature is highly relevant to public health. The knowledge provided by the proposed detailed analysis of ER network brain region interactions will provide important neuroscientific understanding about how affective and cognitive brain systems interact to modulate emotion in various ways. This will be useful not only for depression, but also to research of numerous other psychiatric disorders.

描述（由申请人提供）：该项目的目标是使用功能性 MRI 以及功能/有效连接分析工具来更好地表征参与情绪调节 (ER) 的神经网络，并识别青少年重度抑郁症 (MDD) 中的 ER 网络异常 -一种高度流行、反复发作的精神疾病，其使人衰弱且通常为慢性的性质与公共卫生高度相关。所提出的对 ER 网络大脑区域相互作用的详细分析所提供的知识将为关于情感和认知大脑系统如何相互作用以各种方式调节情绪提供重要的神经科学理解。这不仅对抑郁症有用，而且对许多其他精神疾病的研究也有用。

项目成果

期刊论文数量（2）

专著数量（0）

科研奖励数量（0）

会议论文数量（0）

专利数量（0）

Neural correlates of non-specific skin conductance responses during resting state fMRI.

静息状态功能磁共振成像期间非特异性皮肤电导反应的神经相关性。

DOI：
10.1016/j.neuroimage.2020.116721
发表时间：
2020
期刊：
NeuroImage
影响因子：
5.7
作者：
Gertler,Joshua;Novotny,Stephanie;Poppe,Andrew;Chung,YuSun;Gross,JamesJ;Pearlson,Godfrey;Stevens,MichaelC
通讯作者：
Stevens,MichaelC