Integrative computational models of latent behavioral and neural constructs in children: a longitudinal developmental big-data approach

儿童潜在行为和神经结构的综合计算模型：纵向发展大数据方法

• 批准号: 10631143
• 负责人: VINOD MENON
• 金额: $ 78.31万
• 依托单位: STANFORD UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2019
• 资助国家: 美国
• 起止时间: 2019-07-26 至 2025-05-31
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10631143
• 关键词: Acceleration; Adolescent; Attention deficit hyperactivity disorder; Behavioral; Behavioral Model; Belief; Big Data; Brain; Child; Clinical; Cognition; Cognitive; Computer Models; Development; Dimensions; Early treatment; Goals; Impairment; Learning; Link; Measures; Mental disorders; Methods; Mission; Modeling; Monitor; National Institute of Mental Health; Performance; Process; Psychopathology; Reaction Time; Reproducibility; Research; Research Domain Criteria; Risk; Sampling; Schizophrenia; Stimulus; Substance abuse problem; Symptoms; Time; Update; autism spectrum disorder; base; behavior measurement; behavioral construct; biomarker development; brain behavior; cognitive development; cognitive process; cognitive system; cohort; early detection biomarkers; expectation; externalizing behavior; flexibility; innovation; insight; neural; neural circuit; neurodevelopment; novel; trait

Project Abstract Impairments in cognitive systems that regulate the ability to adaptively engage with and respond to changing stimuli and goals are a hallmark of psychopathology. Identifying the underlying cognitive and neural factors that drive dysfunctional behavioral dynamics is a primary goal for psychiatric research. However conventional methods are unable to reveal latent constructs that govern these dynamic processes. Novel computational approaches are required to reveal latent behavioral dynamics and traits associated with psychopathology, and their neural circuit basis, within the Research Domain Criteria (RDoC) framework. Most, if not all, psychiatric disorders have a neurodevelopmental origin and are associated with atypical maturation of cognitive brain networks. Cognition is a dynamic process, which relies on flexible inhibitory control, goal-directed beliefs that impact moment-to-moment expectation, and the capacity to learn and adapt from prior decisions. Developing dynamic latent behavioral models of cognition is significant in the context of psychopathology, because deficits in inhibitory control, performance monitoring and belief updating are implicated in multiple psychiatric disorders including ADHD, autism, and schizophrenia. Our overarching goal is to develop and validate Hierarchical Latent Variable Dynamics (HLVD), a novel integrative computational approach for discovering robust latent behavioral constructs and their neural circuit bases. The proposed studies will leverage the longitudinal Adolescent Behavioral and Cognitive Development (ABCD) study, which has generated unprecedented amounts of “Big Data” (N>5,000) for charting cognitive and brain development in children and adolescents over time. Crucially, HLVD will be used to identify and validate novel latent constructs of behavioral dynamics that are expected to be significant dimensional predictors of externalizing symptoms and developmental psychopathology. The proposed studies will significantly enhance our understanding of RDoC constructs and provide new insights into latent behavioral dynamics and traits associated with psychopathology in the developing brain. Our studies are highly relevant to the mission of the NIMH initiative RFA-MH-19-242, which seeks to accelerate research on neurodevelopment and trajectories of risk for mental illness. Our innovative approach will ultimately aid in the development of biomarkers for early detection and treatment of psychiatric disorders.

项目摘要 调节适应性参与和响应变化的能力的认知系统受损 刺激和目标是精神病理学的一个标志，识别潜在的认知和神经因素。 驱动功能失调的行为动力学是精神病学研究的主要目标。 方法无法揭示控制这些动态过程的潜在结构。 需要采取方法来揭示与精神病理学相关的潜在行为动态和特征，并且 他们的神经回路基础，在研究领域标准（RDoC）框架内，大多数（如果不是全部）都是精神病学的。 疾病具有神经发育起源，并与认知脑的非典型成熟有关 认知是一个动态过程，依赖于灵活的抑制控制、目标导向的信念。 这会影响每时每刻的期望，以及从先前决策中学习和适应的能力。 发展动态的潜在认知行为模型在精神病理学背景下具有重要意义， 因为抑制控制、表现监控和信念更新方面的缺陷与多种因素有关 我们的首要目标是开发和治疗精神疾病，包括多动症、自闭症和精神分裂症。 验证分层潜变量动力学 (HLVD)，这是一种新颖的综合计算方法 拟议的研究将发现强大的潜在行为结构及其神经回路基础。 利用纵向青少年行为和认知发展（ABCD）研究，该研究已 生成了前所未有的大量“大数据”（N>5,000），用于绘制认知和大脑发育图表 至关重要的是，HLVD 将用于识别和验证新的潜在结构。 行为动力学预计将成为外化症状的重要维度预测因子 拟议的研究将显着增强我们对心理发育病理学的理解。 RDoC 构建并提供了有关潜在行为动态和特征的新见解 我们的研究与 NIMH 倡议的使命高度相关。 RFA-MH-19-242，旨在加速对神经发育和精神风险轨迹的研究 我们的创新方法最终将有助于开发用于早期检测和治疗的生物标记物。 精神疾病的治疗。

项目成果

Developmental Maturation of Causal Signaling Hubs in Voluntary Control of Saccades and Their Functional Controllability.

• DOI: 10.1093/cercor/bhab514
• 发表时间: 2022-01
• 期刊: Cerebral cortex
• 影响因子: 3.7
• 作者: Yuan Zhang;S. Ryali;Weidong Cai;Kaustubh Supekar;R. Pasumarthy;A. Padmanabhan;Beatriz Luna;V. Menon