CORE--CLINICAL

核心--临床

• 批准号: 6457023
• 负责人: WILLIAM R MARKESBERY
• 金额: $ 25.46万
• 依托单位: UNIVERSITY OF KENTUCKY
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-06-01 至 2002-04-30
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6457023
• 关键词: Alzheimer's disease; biomedical facility; brain disorder diagnosis; cognition; dementia; electroencephalography; human old age (65+); human subject; longitudinal human study; magnetic resonance imaging; medical outreach /case finding; neuropsychological tests; patient /disease registry; psychological tests; psychometrics; single photon emission computed tomography; tissue donors

The overall objective of the Clinical Core is to recruit, evaluate and follow patients with Alzheimer's disease (AD), related dementing disorders and normal controls to provide well-characterized subjects for clinical research projects and subsequent pathologic studies. The specific aims are a) to recruit, evaluate and systematically longitudinally follow patients with AD and related dementing disorders, b) to recruit and evaluate a series of cognitively normal community-dwelling (N=400) or nursing home (N=50) volunteer control subjects who have consented to prearranged autopsy, c) to provide a systematic longitudinal follow-up of cognitive function (annual) and neurologic findings (every other year) of control subject, d) to maintain a clinical, neuropsychologic and behavioral database on AD, related dementing disorders, and control subjects, e) to increase the number of AD patients who come to autopsy and then investigate associations between neurologic, neuropsychologic, and behavioral findings as they relate to quantitative histopathologic and regional changes found at autopsy, f) to continue participation in multicenter therapeutic drug trial, g) to continue participation in consortium projects including the AD Cooperative Studies and CERAD, h) to increase the number of AD and related disorders patients (minority and rural) in our Satellite Diagnostic and Treatment Clinics, and i) to enroll minority and rural control subjects through our Satellite Diagnostic and Treatment Clinics. We presently follow 500 patients in our Memory Disorders Clinic. We have recruited 317 cognitively normal volunteer control subjects, all of whom have consented to brain donation at death.

临床核心的总体目标是招募，评估和 跟随患有阿尔茨海默氏病（AD）的患者，相关的痴呆症 和正常对照，为临床提供良好的受试者 研究项目和随后的病理研究。 具体目标 a）招募，评估和系统地遵循 AD和相关痴呆障碍的患者，b）招募和 评估一系列认知正常的社区居住（n = 400）或 疗养院（n = 50）已同意 尸检，c）提供系统的纵向随访 认知功能（年度）和神经系统发现（每隔一年） 控制主题，d）维持临床，神经心理学和 AD，相关痴呆障碍和控制的行为数据库 受试者，e）增加尸检和 然后研究神经系统，神经心理学和 与定量组织病理学有关的行为发现和 尸检时发现的区域变化，f）继续参与 多中心治疗药物试验，g）继续参与 财团项目，包括AD合作研究和Cerad，h） 增加AD和相关疾病患者的数量（少数和 乡村）在我们的卫星诊断和治疗诊所中，i）注册 通过我们的卫星诊断和农村控制对象 治疗诊所。 目前，我们在记忆障碍诊所中关注500名患者。 我们有 招募了317个认知正常的志愿控制对象，所有人都 已同意死亡时的大脑捐赠。