CORE--NEUROPATHOLOGY

核心--神经病理学

• 批准号: 6611074
• 负责人: PIERLUIGI GAMBETTI
• 金额: $ 20.26万
• 依托单位: CASE WESTERN RESERVE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-07-15 至 2003-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6611074
• 关键词: Alzheimer's disease; Lewy body; amyloid proteins; animal tissue; biomedical facility; brain disorder diagnosis; human tissue; morphometry; neuritic plaques; neurofibrillary tangles; neuropathology; postmortem; tissue resource /registry

DESCRIPTION (Adapted from the application): The diagnosis of AD and most other dementing illnesses can be definitively established only after histological examination of brain tissues and in some cases after biochemical and genetic analyses. The purposes of the neuropathology core are to: 1) provide adequately preserved and well characterized human and animal brain tissue samples for the biochemical and morphometric studies planned in the research projects and for the ongoing research program supported by other grants, 2) identify the neuropathologic changes in the subjects with cognitive and/or neurological deficits and to investigate the presence of pathologic alterations in control subjects, 3) establish number and distribution of selected lesions using morphometric analysis to correlate severity and topography of the lesions with cognitive neurological findings when requested by the investigators, 4) to determine presence, type, and severity of structural lesions in transgenic (Tg) mouse models of AD or other immunohistochemical examinations, and 5) adequately store frozen and fixed tissues for future studies that may be carried out in this and other institutions. Currently, the core stores frozen samples from 368 brains, 232 of which are cases of AD, 92 of other neurodegenerative diseases associated with dementia and 23 controls. Six AD and three cases of frontal-lobe dementia are familial. During the previous five years, the core has examined and stored 86 brains from the Registry cases, 73 of which were AD alone or in combination with other processes. With the partial support from other sources, the core has also acquired and stored 669 brains to confirm or exclude prion diseases or to pursue research projects. Sporadic and familial prion diseases were confirmed in 483 cases. Tissues acquired by the core have been used in 186 publications. The essential role and productivity of the core will be maintained during the next five years.

描述（改编自应用程序）：AD 的诊断和大多数 其他痴呆症只有在以下情况后才能明确确定： 脑组织的组织学检查，在某些情况下经过生化检查 和遗传分析。神经病理学核心的目的是：1) 提供保存充分且特征明确的人类和动物大脑 计划中用于生化和形态测量研究的组织样本 研究项目以及其他支持的正在进行的研究计划 赠款，2）确定认知受试者的神经病理学变化 和/或神经功能缺陷并调查病理学的存在 控制对象的改变，3) 确定控制对象的数量和分布 使用形态测量分析选定的病变以关联严重程度和 根据要求提供病变地形图和认知神经学检查结果 由调查人员，4) 确定是否存在、类型和严重程度 AD 或其他疾病的转基因 (Tg) 小鼠模型中的结构损伤 免疫组织化学检查，5) 充分冷冻和固定 用于未来可能在本研究和其他研究中进行的研究的组织 机构。目前，该核心存储了来自 368 个大脑、232 个大脑的冷冻样本。 其中包括 AD 病例，92 例与其他神经退行性疾病相关 患有痴呆症和 23 名对照。 AD 6 例，额叶 3 例 痴呆症具有家族性。在过去的五年里，核心审查了 并保存了 86 个登记病例的大脑，其中 73 个是单独的 AD 或在 与其他工艺相结合。在其他人的部分支持下 消息人士称，核心还获取并存储了669个大脑，以确认或 排除朊病毒疾病或开展研究项目。散发性和家族性 483例确诊为朊病毒病。核心获得的组织有 已在 186 种出版物中使用。的重要作用和生产力 核心将在未来五年内得到维护。