ACOUSTIC COMMUNICATION AND HORMONE CONTROL

声音通讯和激素控制

• 批准号: 6363678
• 负责人: Walter Wilczynski
• 金额: $ 12.17万
• 依托单位: UNIVERSITY OF TEXAS AT AUSTIN
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-10 至 2003-02-28
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6363678
• 关键词: Anura; Rana; animal communication behavior; behavioral /social science research tag; blood chemistry; brain mapping; gonadotropin releasing factor; hormone regulation /control mechanism; immunocytochemistry; neural plasticity; neuroendocrine system; perfusion; preoptic areas; radionuclide double label; sensory feedback; sex hormones; tyrosine 3 monooxygenase

DESCRIPTION (adapted from applicant's abstract): This project will use anuran amphibians as a model system to investigate the interaction of vertebrate communication behavior and hormonal control systems. Behavioral manipulations will test the hypothesis that repeated exposure to conspecific communication signals increases plasma sex steroid levels and changes the anatomical characteristics of three neurochemical systems in brain thought to be involved in hormonal regulation and reproductive control: the gonadotropin releasing hormone (GnRH) centers in the medical septal area and preoptic area expressing the mammalian LHRH form of this peptide, the tegmental GnRH center expressing the chicken II form of GnRH, and the tyrosine hydroxylase (TH) populations in the basal forebrain. Behavioral and hormonal manipulations will then test between two competing hypotheses: that any CNS changes observed are due to feedback from sex steroids released by exposure to conspecific calls vs. that CNS changes are directly due to sensory stimulation of these areas. In addition, neuroanatomical tracing experiments and immunohistochemistry will determine the connections of the medial septal LHRH areas and the tegmental chicken II GnRH area to determine which GnRH populations send efferents to the median eminence and neurohypophysis and hence may control sex steroid secretion from the gonads. Finally, sensory inputs to the medial septal area LHRH and tegmental chicken II GnRH centers will be examined to test the hypothesis that they, like the preoptic area and ventral hypothalamus centers previously examined, receive auditory input (conveying formation about communication signals) in a convergent pattern from the thalamus and isthmal tegmentum. The anatomical results will be related to the behavioral results to test the hypotheses: that both LHRH and chicken II GnRH neurons contribute to neurosecretory functions, and hence, the control of sex steroid secretion; that both forms are equally influenced by the reception of conspecific calls; and that both neurosecretory and non-neurosecretory subpopulations of each form, if such subdivisions exist, are equally influenced by the reception of conspecific calls. The project will enhance the understanding of sensory-endocrine interactions that are fundamental to a variety of natural behaviors with clinical significance, including reproduction and stress.

描述（改编自申请人的摘要）：该项目将使用 无尾两栖动物作为研究相互作用的模型系统 脊椎动物的交流行为和激素控制系统。 行为方面 操作将检验重复暴露于同种动物的假设 通讯信号增加血浆性类固醇水平并改变 大脑思维中三个神经化学系统的解剖特征 参与荷尔蒙调节和生殖控制： 促性腺激素释放激素 (GnRH) 中心位于医学间隔区， 表达该肽的哺乳动物 LHRH 形式的视前区 表达鸡 II 型 GnRH 的被盖 GnRH 中心，以及 基底前脑中的酪氨酸羟化酶（TH）群体。 行为方面 然后荷尔蒙操纵将在两个相互竞争的假设之间进行测试： 观察到的任何中枢神经系统变化都是由于释放的性类固醇的反馈 通过暴露于同种呼叫与 CNS 变化直接归因于 这些区域的感官刺激。 此外，神经解剖追踪实验和免疫组织化学 将确定内侧间隔 LHRH 区域和 被盖鸡 II GnRH 区域以确定哪些 GnRH 群体发送 传出至正中隆起和神经垂体，因此可以控制 性腺分泌性类固醇。 最后，感官输入 内侧间隔区 LHRH 和被盖鸡 II GnRH 中心将 检查以检验以下假设：它们喜欢视前区和 先前检查过的下丘脑腹侧中心接收听觉输入 （传送有关通信信号的信息）以收敛模式 来自丘脑和峡部被盖。 解剖结果将是 与测试假设的行为结果相关：LHRH 鸡 II GnRH 神经元有助于神经分泌功能，并且 因此，控制性类固醇的分泌；两种形式是平等的 受同种呼叫接收的影响；并且两者 每种形式的神经分泌和非神经分泌亚群，如果有的话 细分存在，同样受到同种接受的影响 来电。 该项目将增强对感觉内分泌的理解 各种自然行为的基础相互作用 临床意义，包括繁殖和应激。