Acoustic Communication and Hormone Control

声音交流和激素控制

• 批准号: 7086828
• 负责人: Walter Wilczynski
• 金额: $ 19.41万
• 依托单位: GEORGIA STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 1998
• 资助国家: 美国
• 起止时间: 1998-03-10 至 2008-05-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/7086828
• 关键词: Anura; aggression; androgen receptor; androgens; animal communication behavior; aromatase; behavior test; behavioral /social science research tag; cAMP response element binding protein; experience; gonadotropin releasing factor; hormone regulation /control mechanism; immunocytochemistry; mathematical model; neural plasticity; neuroanatomy; neuroendocrine system; neurogenesis; protein localization; sensory feedback; sex behavior; sex hormones; social behavior; tyrosine 3 monooxygenase; vasotocin; Anura; aggression; androgen receptor; androgens; animal communication behavior; aromatase; behavior test; behavioral /social science research tag; cAMP response element binding protein; experience; gonadotropin releasing factor; hormone regulation /control mechanism; immunocytochemistry; mathematical model; neural plasticity; neuroanatomy; neuroendocrine system; neurogenesis; protein localization; sensory feedback; sex behavior; sex hormones; social behavior; tyrosine 3 monooxygenase; vasotocin

DESCRIPTION (provided by applicant): This project investigates the ways in which participation in social interactions change brain systems associated with reproductive function, and the hormones and behavior they control. Following previous work the project will focus on three forebrain systems, the gonadotropin releasing hormone cells that directly control the pituitary and its regulation of gonadal steroids, tyrosine hydroxylase (dopaminergic) containing cells in several locations that participate in several processes related to reward, motor control, and several aspects of male sexual behavior and endocrine control, and arginine vasotocin ceils which comprise an important neuromodulator system influencing social behavior and communication. The project uses a combination of behavioral tests, endocrinological manipulations, and neuroanatomical methods (particularly immunocytochemistry), tied together with statistical model testing using Structural Equation Modeling, to test several hypotheses about the way in which exposure to communication signals associated with sociosexual behavior sculpt brain systems. It will test the specific hypothesis that sex steroid changes triggered by social stimulation is the critical, mediating factor in inducing the neural changes resulting from such stimulation and examine alternative mechanistic routes by which androgens might act. It will also test two hypotheses concerning the mechanisms underlying the neural changes: that the resultant neural changes involve activation of the pCREB signaling pathway that has been demonstrated to be important in other brain areas for mediating neural plasticity associated with cognitive memory, and/or that the neural changes reflect an increase in neurogenesis. Furthermore, it will compare changes induced by social stimulation to those induced by changes in hormonal state independent of social cues. Supporting the hypothesis driven portions of the project will be more descriptive studies identifying the location of androgen receptors and aromatase enzymes so as to provide neuroanatomical data with which to interpret the hormonal effects on the three target populations and more generally on any observed patterns of pCREB formation and neurogenesis up-regulation. Lastly, the data obtained in different portions of the project will be employed to test alternative hypotheses about the causal relationships among the brain changes, the hormonal changes, and the behavioral changes induced by social stimulation. The project will enhance the understanding of the ways in which social interactions change the levels of circulating sex and stress hormones in an individual, and how these changes may in turn affect the brain systems important for controlling sexual behavior, aggression, and endocrine regulation. These are all natural behaviors with clinical significance, as dysfunctions of sexual response and reproductive function, affiliation and aggression, and stress are important human clinical problems.

描述（由申请人提供）：该项目研究了参与社交互动的方式改变与生殖功能相关的大脑系统以及它们控制的激素和行为。 Following previous work the project will focus on three forebrain systems, the gonadotropin releasing hormone cells that directly control the pituitary and its regulation of gonadal steroids, tyrosine hydroxylase (dopaminergic) containing cells in several locations that participate in several processes related to reward, motor control, and several aspects of male sexual behavior and endocrine control, and arginine vasotocin ceils which comprise an重要的神经调节剂系统影响社会行为和沟通。该项目结合了行为测试，内分泌学操作和神经解剖学方法（尤其是免疫细胞化学），使用结构方程模型与统计模型测试相关联，以测试与与社会性行为行为型灌肠灌肠系统相关的通信信号相关的几个假设。它将检验以下特定的假设：社会刺激引起的性类固醇变化是诱导这种刺激引起的神经变化的关键因素，并检查了雄激素可能作用的替代机械途径。它还将检验两个关于神经变化的机制的假设：由此结果的神经变化涉及激活PCREB信号传导途径，该途径已被证明在其他大脑区域中对介导与认知记忆相关的神经可塑性很重要，并且/或或/或神经变化反映了神经发生的增加。 此外，它将比较由社会刺激引起的变化与荷尔蒙状态变化所引起的变化，而与社会提示无关。支持该项目的假设驱动部分将是更具描述性的研究，以识别雄激素受体和芳香化酶的位置，以提供神经解剖学数据，以解释对三个目标人群的激素效应，以及对PCREB形成和神经发生上的任何观察到的模式上的综合性。最后，将使用项目的不同部分获得的数据来检验有关大脑变化，激素变化以及社交刺激引起的行为变化的替代假设。该项目将增强对社交互动方式改变个人循环性和压力激素水平的理解，以及这些变化如何影响大脑系统对控制性行为，侵略和内分泌调节重要的重要性。这些都是具有临床意义的自然行为，因为性反应和生殖功能，隶属关系和侵略性的功能障碍，压力是人类的重要临床问题。