SPATIAL AND TEMPORAL DYNAMICS OF LEISHMANIA MEXICANA

墨西哥利什曼原虫的时空动态

• 批准号: 6301778
• 负责人: SARA F KERR
• 金额: $ 6.42万
• 依托单位: UNIVERSITY OF THE INCARNATE WORD
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2000-09-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6301778
• 关键词: Psychodidae; Rodentias; United States; animal mortality; animal population density; climate; computer simulation; data collection; disease /disorder proneness /risk; disease reservoirs; environment; epizootiology; field study; host organism interaction; leishmaniasis; longitudinal animal study; polymerase chain reaction; seasons; skin infection; tissue /cell culture; zoonosis

The long-term objective of this research is the understanding of the role of woodrats (Neotoma sp.) As reservoirs of Leishmania in North America, and the role of associated sand flies (Lutzomysia sp.) As vectors among the woodrats and to humans. The following hypotheses will be tested: I. The southern plains woodrat (Neotoma micropus) is the reservoir of L. mexicana throughout its range, where suitable vectors are present. II. Lutzomyia anthrophora is the vector among woodrats throughout its range. III. Temporal and spatial change in prevalence of L. mexicana in N. micropus is highly correlated with change in abundance of Lu. anthrophora. IV. Beyond the geographic range of Neotoma micropus, other woodrat species replace it as reservoirs of Leishmania. V. Beyond the geographic range of Lu anthrophora, other species of Lutzomyia replace it as vectors of Leishmania. VI. Species of Lutzomyia other than Lu. anthophora are vectors to humans. Studies of the seasonal dynamics of Leishmania mexicana will continue at Medina Annex, at 7500 training annex for Lackland Air Force Base in San Antonio, Texas, where current studies have established an abundance of woodrats, sandflies and Leishmania mexicana. In addition, three research trips/year will be made to localities where Neotoma spp. Co- exists with Lutzomyia spp., including Colorado, California, Oklahoma, and Ohio. Woodrats and sand flies will be collected and screened for L. mexicana.

这项研究的长期目标是了解林鼠 (Neotoma sp.) 作为北美利什曼原虫宿主的作用，以及相关白蛉 (Lutzomysia sp.) 作为林鼠和人类媒介的作用。将检验以下假设： I. 南部平原林鼠 (Neotoma micropus) 是整个墨西哥 L. mexicana 的宿主，那里存在合适的载体。二. Lutzomyia anthrophora 是整个林鼠分布范围内的媒介。三．小猪笼草中墨西哥 L. mexicana 流行率的时间和空间变化与 Lu 丰度的变化高度相关。拟人。四．除了Neotoma micropus 的地理范围之外，其他林鼠物种取代它成为利什曼原虫的宿主。五、在Lu anthrophora的地理范围之外，其他Lutzomyia物种取代它成为利什曼原虫的媒介。六． Lu 以外的 Lutzomyia 物种。 anthophora 是人类的媒介。对墨西哥利什曼原虫季节性动态的研究将在得克萨斯州圣安东尼奥拉克兰空军基地 7500 训练附件的麦地那附件继续进行，目前的研究已确定那里有大量的林鼠、白蛉和墨西哥利什曼原虫。此外，每年将前往 Neotoma spp. 所在的地区进行 3 次研究旅行。与 Lutzomyia spp. 共存，包括科罗拉多州、加利福尼亚州、俄克拉荷马州和俄亥俄州。将收集林鼠和白蛉并筛选墨西哥 L. mexicana。