SPATIAL AND TEMPORAL DYNAMICS OF LEISHMANIA MEXICANA

墨西哥利什曼原虫的时空动态

• 批准号: 6301778
• 负责人: SARA F KERR
• 金额: $ 6.42万
• 依托单位: UNIVERSITY OF THE INCARNATE WORD
• 依托单位国家: 美国
• 财政年份: 2000
• 资助国家: 美国
• 起止时间: 2000-03-01 至 2000-09-18
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6301778
• 关键词: Psychodidae; Rodentias; United States; animal mortality; animal population density; climate; computer simulation; data collection; disease /disorder proneness /risk; disease reservoirs; environment; epizootiology; field study; host organism interaction; leishmaniasis; longitudinal animal study; polymerase chain reaction; seasons; skin infection; tissue /cell culture; zoonosis

The long-term objective of this research is the understanding of the role of woodrats (Neotoma sp.) As reservoirs of Leishmania in North America, and the role of associated sand flies (Lutzomysia sp.) As vectors among the woodrats and to humans. The following hypotheses will be tested: I. The southern plains woodrat (Neotoma micropus) is the reservoir of L. mexicana throughout its range, where suitable vectors are present. II. Lutzomyia anthrophora is the vector among woodrats throughout its range. III. Temporal and spatial change in prevalence of L. mexicana in N. micropus is highly correlated with change in abundance of Lu. anthrophora. IV. Beyond the geographic range of Neotoma micropus, other woodrat species replace it as reservoirs of Leishmania. V. Beyond the geographic range of Lu anthrophora, other species of Lutzomyia replace it as vectors of Leishmania. VI. Species of Lutzomyia other than Lu. anthophora are vectors to humans. Studies of the seasonal dynamics of Leishmania mexicana will continue at Medina Annex, at 7500 training annex for Lackland Air Force Base in San Antonio, Texas, where current studies have established an abundance of woodrats, sandflies and Leishmania mexicana. In addition, three research trips/year will be made to localities where Neotoma spp. Co- exists with Lutzomyia spp., including Colorado, California, Oklahoma, and Ohio. Woodrats and sand flies will be collected and screened for L. mexicana.

这项研究的长期目标是理解伍德拉斯（Neotoma sp。）作为北美利什曼尼亚水库的作用，以及相关的沙蝇（Lutzomysia sp。）作为伍德拉斯和人类中的矢量的作用。将测试以下假设：I。南平原伍德拉特（Neotoma Micropus）是墨西哥l. soxicana的储层，在其整个范围内都存在合适的载体。 ii。 Lutzomyia Anthrophora是伍德拉斯整个范围内的载体。 iii。墨西哥乳杆菌中乳杆菌患病率的时间和空间变化与LU的丰度变化高度相关。拟人。 iv。除了新瘤菌群的地理范围之外，其他伍德拉特物种将其取代为利什曼原虫的储层。 V.除了lu Anthrophora的地理范围之外，其他Lutzomyia种类替代了Luishmania的载体。 vi。 Lu以外的Lutzomyia种。 Anthophora是人类的向量。对墨西哥利什曼尼亚利什曼尼亚季节动态的研究将继续在麦地那附件，在得克萨斯州圣安东尼奥的拉克兰空军基地的7500培训附件，当前的研究确立了大量的伍德拉斯，沙弗里斯和墨西哥利什曼尼亚。此外，每年将进行三次研究旅行，到Neotoma spp的地区。与Lutzomyia spp。合作，包括科罗拉多州，加利福尼亚，俄克拉荷马州和俄亥俄州。将收集木蝇和沙子，并筛选墨西哥L.。