SPATIAL AND TEMPORAL DYNAMICS OF LEISHMANIA MEXICANA

墨西哥利什曼原虫的时空动态

• 批准号: 6645917
• 负责人: SARA F KERR
• 金额: $ 6.42万
• 依托单位: UNIVERSITY OF THE INCARNATE WORD
• 依托单位国家: 美国
• 财政年份: 2002
• 资助国家: 美国
• 起止时间: 2002-08-01 至 2003-07-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6645917
• 关键词: Leishmania; Psychodidae; Rodentias; United States; animal mortality; animal population density; climate; computer simulation; data collection; disease /disorder proneness /risk; disease reservoirs; environment; epizootiology; field study; geographic site; host organism interaction; leishmaniasis; longitudinal animal study; mathematical model; parasitism; polymerase chain reaction; seasons; tissue /cell culture; zoonosis

DESCRIPTION (provided by applicant): The aims of this research are to determine the biogeographic distribution of Leishmania mexicana, to further clarify the role of woodrats (Neotoma spp.) as reservoirs and sand flies (Lutzomyia spp.) as enzootic vectors, and to determine environmental factors that influence transmission. This information is essential to prevent the emergence or introduction of leishmaniasis in the United States, and to reduce transmission to humans in countries such as Nicaragua, where severe outbreaks are presently occurring. Strengths of this study are that it is highly interdisciplinary (ecology, biogeography, mammalogy, entomology, parasitology, modeling, molecular biology, evolutionary biology), and studies will be conducted at several spatial and temporal scales.

描述（由申请人提供）：本研究的目的是确定 墨西哥利什曼原虫的生物地理分布，以进一步阐明 林鼠（Neotoma spp.）作为宿主和白蛉（Lutzomyia spp.）的作用 作为地方性动物媒介，并确定影响的环境因素 传播。该信息对于防止出现或 利什曼病传入美国并减少传播 尼加拉瓜等国家的人类目前疫情严重 发生。这项研究的优点是它是高度跨学科的 （生态学、生物地理学、哺乳动物学、昆虫学、寄生虫学、建模、 分子生物学、进化生物学），研究将在 几个空间和时间尺度。