HUMAN GRANULOCYTIC EHRLICHIOSIS: NORTH CENTRAL U.S.

人类粒细胞埃里希体病：美国中北部

• 批准号: 6259331
• 负责人: RUSSELL C JOHNSON
• 金额: $ 36.56万
• 依托单位: UNIVERSITY OF MINNESOTA
• 依托单位国家: 美国
• 财政年份: 2001
• 资助国家: 美国
• 起止时间: 2001-02-01 至 2006-01-31
• 项目状态: 已结题
• 来源: https://reporter.nih.gov/project-details/6259331
• 关键词: Carnivora; Ixodes; Rodentias; Ungulate; United States; arthropod borne communicable disease; communicable disease transmission; disease reservoirs; dogs; ehrlichiosis; emerging infectious disease; epizootiology; geographic site; human tissue; polymerase chain reaction; public health; restriction fragment length polymorphism; serology /serodiagnosis; tissue /cell culture; western blottings

DESCRIPTION: Human granulocytic ehrlichiosis (HGE) is an emerging tick-borne acute febrile illness. The agent of HGE is closely related to or identical to the horse pathogen Ehrlichia equi and is transmitted by Ixodes scapularis, the same tick that transmits the agents of Lyme disease and babesiosis. The HGE agent infects blood polymorphonuclear neutrophils resulting in neutropenia and a thrombocytopenia. HGE may be a mild to potentially fatal disease. HGE was first described in Minnesota and Wisconsin in 1994 and subsequently more than 400 cases have been described in the U.S. In contrast to Lyme disease which frequently occurs in children, the rates and severity of HGE increase with age. This age-specific incidence of HGE and our large aging population presents a potentially major public health problem with corresponding economic consequences. This emerging public health problem highlights the importance of early diagnosis and treatment in preventing complications of infection, and targeting of prevention and control studies to populations at highest risk. The research proposed in this application is designed to aid in achieving the above goals by analyzing the epizootiology of HGE in the North Central U.S. Our specific aims are: to investigate the hypothesis that white-tailed deer serve as a large mammal reservoir of the agent of HGE and to identify the small mammal reservoirs of the HGE agent.

描述：人类粒细胞ehrlichiois（HGE）是新兴的tick传播 急性高温疾病。 HGE的代理与 马病原体Ehrlichia Equi，并由ixodes capularis传播 同样传播莱姆病和巴贝斯病的药物的壁虱。 hge 剂感染血液多形核中性粒细胞，导致中性粒细胞减少和 血小板减少症。 HGE可能是一种轻度至潜在的致命疾病。 HGE是 首次在1994年在明尼苏达州和威斯康星州进行了描述，随后超过 与莱姆病相比，美国已经描述了400例 儿童经常发生，HGE的率和严重程度随着年龄的增长而增加。 HGE和我们庞大的老龄化人口的这种特定年龄的发病率提出了A 与相应经济的潜在重大公共卫生问题 结果。这个新兴的公共卫生问题强调了 预防感染并发症的早期诊断和治疗，以及 针对预防和控制研究对处于最高风险的人群。这 本应用程序中提出的研究旨在帮助实现上述 通过分析美国北部中部的HGE的Epizootiology通过我们的目标 具体目的是：研究白尾鹿服务的假设 作为HGE代理商的大型哺乳动物水库，并识别小的 HGE代理的哺乳动物水库。